School of Medicine
Showing 51-100 of 126 Results
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Peter S. Kim
Virginia and D. K. Ludwig Professor of Biochemistry
Current Research and Scholarly InterestsOur research focuses on developing new strategies for vaccine creation. We also aim to generate vaccines targeting infectious agents that have eluded efforts to date. We integrate experimental approaches with protein language models to guide artificial evolution and enable efficient antibody and protein engineering. Our interdisciplinary approach aims to address critical global health challenges.
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Silvana Maria Konermann
Assistant Professor of Biochemistry
BioSilvana is an Assistant Professor of Biochemistry at Stanford and Executive Director and Core Investigator at Arc Institute. Her research laboratory aims to understand the molecular pathways that drive the development of Alzheimer’s disease using next-generation functional genomics, with the long-term goal of developing rationally targeted therapeutics for neurodegenerative disorders. She received her Ph.D. in Neuroscience from MIT. Silvana’s pioneering work on tools to directly perturb the transcriptomic landscape of the cell using CRISPR has been recognized by her faculty appointment as a Chan Zuckerberg Biohub Investigator and Hanna Gray Fellow of the Howard Hughes Medical Institute.
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Mark Krasnow
Paul and Mildred Berg Professor
Current Research and Scholarly Interests- Lung development and stem cells
- Neural circuits of breathing and speaking
- Lung diseases including lung cancer
- New genetic model organism for biology, behavior, health and conservation -
I Lehman
William M. Hume Professor in the School of Medicine, Emeritus
Current Research and Scholarly InterestsWe study Herpes simplex virus type 1 as a model eukaryotic chromosome for the analysis of eukaryotic DNA replication and recombination
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Lingyin Li
Professor of Biochemistry
BioDr. Li is a professor in the Biochemistry Department and ChEM-H Institute at Stanford. She is also a core investigator of the Arc Institute. Her lab works on understanding biochemical mechanisms of the immunotransmitter cGAMP and harnessing it to treat cancer and autoimmunity. She majored in chemistry at University of Science and Technology of China and graduated with a B. En in 2003. She then trained with Dr. Laura Kiessling, a pioneer in chemical biology, at University of Wisconsin-Madison and graduated with a Ph.D in chemistry in 2010. She obtained her postdoctoral training with Dr. Timothy Mitchison at Harvard Medical School, who introduced her to the field of chemical immunology. She started her lab at Stanford in 2015.
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Sharon R. Long
William C. Steere, Jr. - Pfizer Inc. Professor of Biological Sciences and Professor, by courtesy, of Biochemistry
Current Research and Scholarly InterestsBiochemistry, genetics and cell biology of plant-bacterial symbiosis
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Asmita Pawar
Postdoctoral Scholar, Biochemistry
BioAsmita Pawar (Ph.D.) is a postdoctoral scholar in the laboratory of Professor James Spudich (Department of Biochemistry) and Dr. Masataka Kawana (Department of Cardiovascular Medicine) at Stanford University School of Medicine.
Asmita received her M.Sc. in Microbiology from University of Pune in 2006, and Ph.D. in Life Sciences from CSIR-Centre for Cellular & Molecular Biology (CCMB), Hyderabad, India in 2021. After M.Sc., she served as a lecturer in Dept. of Microbiology and Biotechnology at Gokhale Education Society’s colleges at Nashik, India (affiliated to the University of Pune) and taught various courses to B.Sc. and M.Sc. students. In 2011, she co-founded ‘Centre for Life Sciences’ institute in Nashik, and mentored BS-MS students for advanced studies and teaching careers until 2013.
During her Ph.D., she worked in the lab of Dr. Yogendra Sharma and investigated the Ca2+-binding features of novel microbial proteins with diverse domain architectures like βγ-crystallins, bacterial immunoglobulin-like (Big) domains, and EF-hand domains. She next joined the Indian Institute of Science Education and Research (IISER) Berhampur, as a postdoctoral fellow and studied the chaperone properties of human Secretagogin (a Ca2+-sensor protein) until June 2023.
Currently, as a postdoctoral trainee with Dr. Kawana, she is characterizing recombinant human α-cardiac myosin and comparing a few of it's in vitro biochemical properties with recombinant β-cardiac myosins. She is further investigating the molecular effects of a few atrial fibrillation-associated mutations in α-cardiac myosin. Parallelly, she is optimizing experiments to evaluate the binding kinetics of cardiac myosins and Myosin-binding Protein-C (MyBP-C) interactions. -
Suzanne Pfeffer
Emma Pfeiffer Merner Professor of Medical Sciences
Current Research and Scholarly InterestsThe major focus of our research is to understand the molecular basis of inherited Parkinson's Disease (PD). We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in specific regions of the brain. The absence of primary cilia renders cells unable to carry out Hedgehog signaling that is critical for neuroprotective pathways that sustain dopamine neurons.
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Rajat Rohatgi
Professor of Biochemistry and of Medicine (Oncology)
Current Research and Scholarly Intereststhe overall goal of my laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states, and to devise new strategies to repair their function.
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Florentine Rutaganira
Assistant Professor of Biochemistry and of Developmental Biology
Current Research and Scholarly InterestsWe use chemical tools to decipher the roles of key signaling networks in choanoflagellates, single-celled organisms that are the closest living relatives of animals. Choanoflagellates produce molecular signals essential for intercellular communication in animals and the presence of these molecules in choanoflagellates suggests that signaling components needed to communicate between cells is evolutionarily ancient. We aim to uncover new understanding of animal development, physiology and disease.
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Julia Salzman
Associate Professor of Biomedical Data Science, of Biochemistry and, by courtesy, of Statistics and of Biology
Current Research and Scholarly Interestsstatistical computational biology focusing on splicing, cancer and microbes
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Jaime B Seltzer
Affiliate, Biochemistry - Genome Center
BioJaime Seltzer is a researcher with Stanford Medicine working with the Synder Lab and at the Stanford Genome Technology Center.
Seltzer is also the Scientific Director at #MEAction for the infection-associated chronic illnesses ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) and Long COVID.
She is responsible for project management for clinical and research-associated projects and fostering communication between research scientists, clinicians, and people with infection-associated chronic illness. Ongoing projects: Society to Improve Diagnosis in Medicine-funded work to transform ME/CFS treatment and diagnosis at Mayo Clinic Rochester; Symptom Cluster Characterization in Complex Chronic Disease; multiple ongoing medical education initiatives. Leading institutional outreach for MEAction's Teach ME, Treat ME campaign.
