School of Medicine


Showing 11-20 of 22 Results

  • Natalia Gomez-Ospina

    Natalia Gomez-Ospina

    Assistant Professor of Pediatrics (Genetics) and of Pediatrics (Stem Cell Transplantation)

    Current Research and Scholarly InterestsDr. Gomez-Ospina is a physician scientist and medical geneticist with a strong interest in the diagnosis and management of genetic diseases.

    1) Lysosomal storage diseases:
    Her research program is on developing better therapies for a large class of neurodegenerative diseases in children known as lysosomal storage disorders. Her current focus is on developing genome editing of hematopoietic stem cells as a therapeutic approach for these diseases beginning with Mucopolysaccharidosis type 1 and Gaucher disease. She established a genetic approach where therapeutic proteins can be targeted to a single well-characterized place in the genome known as a safe harbor. This approach constitutes a flexible, “one size fits all” approach that is independent of specific genes and mutations. This strategy, in which the hematopoietic system is commandeered to express and deliver therapeutic proteins to the brain can potentially change the current approaches to treating childhood neurodegenerative diseases and pave the way for alternative therapies for adult neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease


    2) Point of care ammonia testing
    She also works in collaboration with other researchers at Stanford to develop point-of-care testing for serum ammonia levels. Such device will greatly improve the quality of life of children and families with metabolic disorders with hyperammonemia.

    3) Gene discovery
    Dr Gomez-Ospina lead a multi-institutional collaboration resulting in the discovery of a novel genetic cause of neonatal and infantile cholestatic liver disease. She collaborated in the description of two novel neurologic syndromes caused by mutations in DYRK1 and CHD4.


    For more information go to our website:

    https://www.gomezospina.com/

  • Louanne Hudgins

    Louanne Hudgins

    Professor of Pediatrics (Genetics) at the Lucile Salter Packard Children's Hospital, Emerita

    Current Research and Scholarly InterestsI am interested in prenatal genetic screening and diagnosis.

  • Akash Kumar

    Akash Kumar

    Adjunct Clinical Instructor, Pediatrics - Medical Genetics

    Current Research and Scholarly InterestsAkash is passionate about taking advances in genomics and applying them for patient care. After training in Chemical and Bioengineering at the University of Minnesota and Stanford University he started the Medical Scientist Training Program (MSTP) at the University of Washington and obtained a PhD in Genome Sciences. With his thesis advisor, Jay Shendure, Akash used next generation sequencing technologies to characterize the development and evolution of prostate cancer and glioblastoma. He also designed and implemented new methods using next-generation sequencing with applications for cancer genetics and prenatal genetic testing. He has published six first-author publications in journals including Nature Medicine, PNAS and Genome Medicine and is a co-inventor on one licensed patent. As a medical geneticist, Akash believes that the best approach to improve outcomes for children with complex congenital medical conditions stems from earlier diagnosis and intervention. To that effect, his current research goals are 1) to develop new genomic methods that identify children at risk for complex congenital diseases earlier, 2) to understand the molecular mechanisms of neurodevelopmental disease in children that may serve as potential avenues for treatment and 3) to improve access and implementation of genomics more broadly in the clinic.

  • maura ruzhnikov

    maura ruzhnikov

    Clinical Assistant Professor, Neurology & Neurological Sciences
    Clinical Assistant Professor (By courtesy), Pediatrics - Medical Genetics

    BioChild neurologist and medical geneticist focusing on the diagnosis and management of rare neurologic disorders. Specific interests are in genetic epilepsy syndromes, childhood neurodegenerative and neurometabolic diseases and undiagnosed suspected genetic conditions.

  • David Stevenson

    David Stevenson

    Professor of Pediatrics (Genetics)

    Current Research and Scholarly InterestsMy research focuses on disorders of the RAS/MAPK pathway (eg. NF1, Noonan, CFC, and Costello syndrome). I am working on understanding the impact of RAS signaling on the musculoskeletal system. I use genomic approaches to identify somatic events and modifiers in the RASopathies. I am also involved in identifying outcome measures for use in clinical trials for the associated orthopedic manifestations. Other areas of research involve vascular anomalies, Prader-Willi syndrome, and hypophosphatasia.