School of Medicine


Showing 881-890 of 938 Results

  • Sui Wang, PhD

    Sui Wang, PhD

    Assistant Professor of Ophthalmology

    Current Research and Scholarly InterestsOur research focuses on understanding the molecular mechanisms that underlie retinal development and diseases. We utilize genetic and genomic tools to uncover how different types of retinal cells, including retinal neurons, glia and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels, and how they interact and collectively contribute to the integrity of the retina.

    1. Retinal cell fate specification.
    We are using genetic tools and methods, such as in vivo plasmid electroporation and CRISPR, to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal cell fate specification.

    2. The multicellular responses elicited by diabetes in the retina.
    Diabetes can induce multicellular responses in the retina, including vascular lesions, glial dysfunction and neurodegeneration, all of which contribute to retinopathy. We are using diabetic rats as models to investigate the detailed molecular mechanisms underlying the diabetes-induced multicellular responses, and the disease mechanisms of diabetic retinopathy.

    3. Molecular tools that allow for cell type-specific labeling and manipulation in vivo.
    Cis-regulatory elements, such as enhancers, play essential roles in directing tissue/cell type-specific and stage-specific expression. We are interested in identifying enhancers that can drive cell type-specific expression in the retina and brain, and incorporating them into plasmid or AAV based delivery systems.

  • Taia T. Wang, MD, PhD, MSCI

    Taia T. Wang, MD, PhD, MSCI

    Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly InterestsLaboratory of Mechanisms in Human Immunity and Disease Pathogenesis

    Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that diversity in antibody-based signaling that arises from diversity in IgG antibodies and their receptors, is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. We are studying how the Fc domain repertoire of an individual impacts the quality of effector cell responses that can be recruited during immune activation and how selectivity of effector responses contributes to immunity and disease.

    SARS-CoV-2, dengue viruses, influenza viruses, disease pathogenesis, influenza vaccines

    Current clinical studies:
    Recruiting:

    An Open Label Study of IgG Fc Glycan Composition in Human Immunity
    Principal Investigator: Taia T. Wang, MD, PhD
    ClinicalTrials.gov Identifier:
    NCT01967238

  • Xinnan Wang

    Xinnan Wang

    Associate Professor of Neurosurgery

    Current Research and Scholarly InterestsMechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.

  • Katja Gabriele Weinacht, MD, PhD

    Katja Gabriele Weinacht, MD, PhD

    Assistant Professor of Pediatrics (Stem Cell Transplantation and Regenerative Medicine)

    Current Research and Scholarly InterestsPediatric Hematopoietic Stem Cell Transplantation
    DiGeorge Syndrome
    Genetic Immune Diseases
    Immune Dysregulation

  • Alexis Thomas Weiner

    Alexis Thomas Weiner

    Postdoctoral Scholar, Pathology

    Current Research and Scholarly InterestsThe planar cell polarity (PCP) signaling pathway polarizes animal cells along an axis parallel to the tissue plane, and in so doing generates long-range organization that can span entire tissues. Although its core proteins and much about their interactions are known, how PCP signaling occurs at a mechanistic level remains fundamentally mysterious. In my current project I will employ novel genetic methods to dissect the logic underlying how cellular asymmetry arises at a molecular level.

  • Dana Weintraub

    Dana Weintraub

    Clinical Associate Professor, Pediatrics - General Pediatrics

    Current Research and Scholarly InterestsResearch interests include: 1) Childhood obesity, community-based interventions to increase physical activity 2) Impact of medical-legal collaboration on child and family health.

  • Irving Weissman

    Irving Weissman

    Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology

    Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis; order of events from hematopoietic stem cells [HSC] to AML leukemia stem cells and blood diseases, and parallels in other tissues; discovery of tumor and pathogenic cell 'don't eat me' and 'eat me' signals, and translation into therapeutics.