Stanford University
Showing 2,501-2,510 of 2,738 Results
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Bo Xiong
Postdoctoral Scholar, Biomedical Informatics
Current Research and Scholarly InterestsAI, Foundation Models, Biomedical Data Science
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熊剑 (Jian Xiong)
Postdoctoral Scholar, Chemical Engineering
BioI thrive to understand the roles of lysosomes in physiological and pathological conditions. Lysosomes are both degradation compartment and metabolic controlling hub, and dysregulation of lysosomal functions are frequently implicated in a vast number of diseases including neurodegenerative diseases, however, the systematic knowledge of the molecular mechanism by which lysosomal contributes to these diseases is lacking. Ion channels are the primary mediators of neuronal activity, defects in neuronal ion channel activity are linked with many kinds of neurodegenerative diseases. Interestingly, besides typical ion channels that are involved in the neuronal activity, defects in lysosomal ion channels, such as TRPML1, CLN7 and CLC-7 are also implicated in neuropathy. My previous work as Ph.D student in University of Texas MD Anderson Cancer Center focused on regulation of lysosomal function by ion channels and metabolites. I discovered a mechanism of lysosomal Na+ channel regulate mTORC1 activation by regulating lysosomal amino acid accumulation. I also discovered role of glutamine in controlling lysosomal degradation capacity. In the meantime, I developed novel methods to isolate organelles. My ultimate research goal is to understand the key developmental pathways and how alterations in gene sequences and expression contribute to human disease, therefore, I am pursuing independent academic researcher as my career goal. Starting Feb 2022, I work with Dr. Monther Abu-Remaileh at Stanford University on role of lysosomes in neurodegenerative diseases. I use genetics, chemical biology and omics approaches to study lysosome function under various physiological and pathological conditions, especially age-associated neurodegenerative disorders, and monogenic neurodegenerative lysosome storage diseases. In Stanford, I aim to integrate ionic regulation, metabolomic regulation and functional proteomic regulation to systematically understand the biology of lysosome in physiological conditions and pathological conditions.
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Lei Xiong
Postdoctoral Scholar, Genetics
Current Research and Scholarly InterestsMy research focuses on develop deep learning methods to
1. Infer macrophage-tumor cells interaction using spatial multi-omics
2. Decipher the cis-regulatory code using a large language models
3. Predict enhancer-promoter interaction
4. Multi-omics integration
5. Build foundational model for single-cell genomics -
CHENHANG XU
Postdoctoral Scholar, Physics
BioI am a postdoctoral researcher at Stanford University in the Zong/Hwang group. I received my undergraduate and doctoral degrees from Shanghai Jiao Tong University (SJTU), where I specialized in pulsed laser deposition, the synthesis of complex oxide materials and MeV ultrafast electron diffraction (UED).
My research focuses on ultrafast structural dynamics in quantum materials using techniques such as MeV-UED, ultrafast electron microscopy (UEM), time-resolved X-ray diffraction, and pump–probe optical spectroscopy. These time-resolved probes are integrated with advanced and highly tunable sample environments, including in situ strain engineering and electrostatic gating, to actively control competing electronic, structural, and ferroic orders. This capability enables the design, discovery, and quantitative understanding of nonequilibrium phases, transient orders, and metastable states in quantum materials.
