Stanford University
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Madison George
Ph.D. Student in Bioengineering, admitted Autumn 2023
Current Research and Scholarly InterestsExertional compartment syndrome (ECS) is a painful condition characterized by abnormally high muscle compartment pressures induced by exercise. The diagnostic procedure for ECS requires the insertion of a needle into the muscle to directly quantify pressure, which is a barrier to both patients and clinicians. We will develop and evaluate new MRI technologies to (1) increase understanding of the pathophysiology of this condition and (2) Improve clinical diagnosis of ECS.
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Paul George, MD, PhD
Associate Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsDEVELOPMENT OF STROKE RECOVERY THERAPEUTICS:
Stroke is devastating to patients and their caregivers. We currently are investigating 3 neural repair approaches. The first focuses on developing a stroke recovery therapeutic based on an essential repair pathway and how it alters the immune response following stroke. The second utilizes implantable, conductive polymer devices to electrically manipulate the recovering nervous system to improve recovery and identify novel therapeutic targets. The final approach works to optimize stem cell therapeutics to enhance their ability to treat patients who have suffered from neural injury.
CONDUCTIVE BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration. Recent work utilizes these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes. -
Rachel Ann George
Lecturer in International Relations & Fellow, Rhode Center, Stanford Law, Center for Study of Legal Profession
BioRachel George is a Lecturer in the International Relations Program at Stanford University, where she is an Affiliate of CISAC and a Legal Innovation & Policy Fellow at Stanford Law School. A political scientist, her research examines how institutions adapt to technological and political change, with a particular focus on artificial intelligence, law and institutional reform, democracy, and governance. Her work explores the intersection of technology, public policy, and accountability.
Previously, she was a Lecturing Fellow at Duke University’s Sanford School of Public Policy and a Visiting Assistant Professor at Duke Kunshan University. She also served as a Director at the Council on Foreign Relations and has held fellowships at Georgetown University and ODI, where her research focused on law, democracy and security.
She is the author of *Bureaucratic Smokescreens*, a book examining the politics of institutional reform and the relationship between evidence and policymaking in foreign policy and development institutions. Her current research explores AI and democracy, security, and technology governance. She is also a Nonresident Scholar at the Carnegie Endowment for International Peace.
At Stanford, she leads the Policy Lab and the Research Capstone Paper course within the Program in International Relations, and teaches Navigating New Frontiers in International Law. She is also Nonresident Scholar with the Carnegie Endowment for International Peace.
Dr. George holds a BA from Princeton University, an MA from Harvard University, and a PhD from the London School of Economics and Political Science.