Stanford University
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Linda Lam
Digital Imaging Production Coordinator, Library Technology
Current Role at StanfordAs part of Stanford Libraries' Digital Production Group (DPG), I coordinate and manage mass digitization projects. My responsibilities include daily oversight of lab personnel and workflows, involving materials preparation, equipment and software troubleshooting, quality control and data management.
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Mable Lam
Instructor, Neurosurgery
Current Research and Scholarly InterestsMyelin is required for rapid nerve signaling by insulating axons to accelerate action potential propagation. Myelin-forming cells of the central nervous system, called oligodendrocytes, orchestrate one of the most complex morphological transformations in neurobiology. Each oligodendrocyte can extend multiple processes that selectively wrap axons in tens to hundreds of spiraling membrane layers, forming myelin sheaths that vary in thickness and length. Furthermore, oligodendrocytes can respond to neural activity by adding new sheaths or by changing the geometry of pre-existing sheaths to tune neural circuitry, a process known as adaptive myelination.
What are the membrane trafficking mechanisms that drive adaptive myelination in oligodendrocytes?
How can these mechanisms be stimulated to promote myelin regeneration in disease?
By using transgenic mouse models and primary oligodendrocytes, we have found that SNARE-mediated exocytosis drives membrane addition in myelin sheaths. Current research is focused on how these pathways in oligodendrocytes may be regulated during adaptive myelination. -
Monica Lam
Kleiner Perkins, Mayfield, Sequoia Capital Professor in the School of Engineering, Professor of Computer Science and, by courtesy, of Electrical Engineering
BioProfessor Lam's current research interest is to create effective and reliable AI assistants to accelerate the discovery of knowledge. Her OVAL lab has created numerous open-source LLM-based tools used by consumers, historians, and journalists in their work; currently, she is focusing on research assistants that can discover new insights for biomedicine and other technical areas.
Professor Lam's team has created the first quantifiably factual and engaging conversational agent, which has won the Best Research of the Year Award from Wikimedia Foundation; pioneered deep research agent called STORM that has been used by about a million users; developed the best-performing agent for retrieving knowledge from hybrid sources, including databases, knowledge graphs, and free-text, currently deployed at Wikimedia; created an agent framework that produces fluent task-oriented agents that do not hallucinate.
Prof. Lam is also an expert in compilers for high-performance machines. Her pioneering work of affine partitioning provides a unifying theory to the field of loop transformations for parallelism and locality. Her software pipelining algorithm is used in commercial systems for instruction level parallelism. Her research team created the first, widely adopted research compiler, SUIF. She is a co-author of the classic compiler textbook, popularly known as the “dragon book”. She was on the founding team of Tensilica, now a part of Cadence.
Dr. Lam is a Member of the National Academy of Engineering and an Association of Computing Machinery (ACM) Fellow.
