Stanford University
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Christopher O. Barnes
Assistant Professor of Biology and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsResearch in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. We combine biophysical and structural methods (e.g., cryo-EM), protein engineering, and in vivo approaches to understand how enveloped viruses infect host cells and elicit antigen-specific immune responses. We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats.
HIV-1; SARS-CoV-2; coronaviruses; cryo-EM; crystallography; vaccines; directed evolution -
Leandra A. Barnes, MD
Instructor, Dermatology
BioDr. Barnes is a board-certified dermatologist who provides care at Stanford Health Care Dermatology Clinics in Redwood City and Emeryville. She is also an Instructor of Dermatology within the Department of Dermatology at Stanford School of Medicine.
Dr. Barnes specializes in diagnosing and treating a broad range of skin conditions, including hidradenitis suppurativa, skin cancer, and conditions that disproportionally impact people of color. As Co-Director of the Stanford Medicine Hidradenitis Suppurativa Specialty Clinic, her clinical focus includes maximizing awareness of and care options for this condition. Dr. Barnes is also the Founding Director of the Stanford Medicine Skin of Color Program and Director of Advocacy, Equity, and Inclusion in the Department of Dermatology at Stanford Medicine.
Dr. Barnes’ clinical research focuses on identifying the underlying mechanisms associated with the onset and progression of hidradenitis suppurativa. These efforts include research on access to care among different patient populations and studies identifying immune-mediated characteristics of the condition. She is also engaged in efforts to promote broader and more effective outreach initiatives to drive melanoma awareness among minority populations and young children.
Dr. Barnes has published her work in numerous peer-reviewed journals, including the Journal of Investigative Dermatology, JAMA Dermatology, and the Journal of the American Academy of Dermatology. She has also been an invited guest speaker at national and international meetings, including those for the Society of Investigative Dermatology and the World Congress of Dermatology.
