Stanford University
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Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioResearch and Scholarship
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
In a second program area, the Du Bois group is exploring voltage-gated ion channel structure and function using the tools of chemistry in combination with those of molecular biology, electrophysiology, microscopy and mass spectrometry. Much of this work has focused on studies of eukaryotic Na and Cl ion channels. The Du Bois lab is interested in understanding the biochemical mechanisms that underlie channel subtype regulation and how such processes may be altered following nerve injury. Small molecule toxins serve as lead compounds for the design of isoform-selective channel modulators, affinity reagents, and fluorescence imaging probes. Access to toxins and modified forms thereof (including saxitoxin, gonyautoxin, batrachotoxin, and veratridine) through de novo synthesis drives studies to elucidate toxin-receptor interactions and to develop new pharmacologic tools to study ion channel function in primary cells and murine pain models. -
Monica M. Dua, MD
Clinical Professor, Surgery - General Surgery
Current Research and Scholarly InterestsTechnical aspects of minimally invasive pancreatic and liver surgery
Minimally invasive strategies for the management of pancreatic necrosis
Management of severe acute pancreatitis – academic vs community treatment
Multidisciplinary treatment of HCC; institutional barriers to appropriate referral/ care
Endocrine/exocrine insufficiency after pancreatectomy; volumetric assessment
Natural history and management of pancreatic cysts -
Junting Duan
Research Asst - Graduate, Program-Pelger, M.
BioJunting Duan is a PhD candidate in the Department of Management Science and Engineering (MS&E) at Stanford University. Prior to joining Stanford, she received her B.S. in Mathematics and Applied Mathematics from Peking University in 2020.
Junting's research interests lie broadly in data-driven decision-making, focusing on statistical inference and machine learning, with applications to causal inference and finance. Her research develops new methodologies with rigorous statistical foundations that enable reliable decision-making with complex and imperfect data, and lies at the intersection of (1) statistical learning for high-dimensional data; (2) causal inference; and (3) machine learning for finance and risk management. Her work has been recognized through publications and revisions at top journals including Management Science and the Journal of Econometrics, as well as invitations to present at major conferences such as the American Economic Association Annual Meeting, the NBER-NSF Time-Series Conference, the NBER Forecasting & Empirical Methods Conference, and the INFORMS Annual Meeting.
Visit her personal website for more details: https://juntingduan.com. -
Dawn Duane
Clinical Professor, Pediatric Neurology
Clinical Professor (By courtesy), PediatricsCurrent Research and Scholarly InterestsI am a general pediatric neurologist. My interest is in clinical diagnosis and treatment of common neurologic diseases in pediatric patients and teaching feature doctors, neurologists and pediatric neurologists about pediatric neurology.
