Stanford University
Showing 51-100 of 1,571 Results
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Soichi Wakatsuki
Professor of Photon Science and of Structural Biology
Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators. -
Claire E Wakefield
Professor of Pediatrics (Quality of Life and Palliative Care)
BioI am a medical psychologist and researcher dedicated to improving quality of life for children affected by serious illness, as well as their families. My research spans pediatric palliative care, precision medicine, psycho-oncology, and global health, and is grounded in a deep commitment to compassionate, patient-centered care. I have published more than 340 journal articles and am named as Chief Investigator on competitive research grants totaling more than $55M.
I served as Continental President of SIOP Oceania and as a Director on the Board of the International Society of Pediatric Oncology (SIOP), advocating for children with cancer across 14 countries. I advise the World Health Organization on global childhood cancer initiatives and am a proud member of the Presidential Task Force on Advocacy for the Society of Pediatric Psychology. I am passionate about building national and global capacity in pediatric palliative care and ensuring that every child and family receives not only the best medical treatment, but also the emotional and psychological support they need. -
Diane Elizabeth Wakeham
Clinical Research Coordinator Associate, Psych/General Psychiatry and Psychology (Adult)
Current Role at StanfordClinical Research Coordinator Associate, INSPIRE Clinic, Psychiatry and Behavioral Sciences
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Heather Wakelee
Winston Chen and Phyllis Huang Professor
Current Research and Scholarly InterestsDr. Wakelee's research is focused on clinical trials and translational efforts in patients with lung cancer and other thoracic malignancies such as thymoma and thymic carcinoma. Other interests include translation projects in thoracic malignancies and collaborations with population scientists regarding lung cancer questions.
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Virginia Walbot
Professor of Biology, Emerita
Current Research and Scholarly InterestsOur current focus is on maize anther development to understand how cell fate is specified. We discovered that hypoxia triggers specification of the archesporial (pre-meiotic) cells, and that these cells secrete a small protein MAC1 that patterns the adjacent soma to differentiate as endothecial and secondary parietal cell types. We also discovered a novel class of small RNA: 21-nt and 24-nt phasiRNAs that are exceptionally abundant in anthers and exhibit strict spatiotemporal dynamics.
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Michael Wald
Jackson Eli Reynolds Professor of Law, Emeritus
BioMichael S. Wald is the Jackson Eli Reynolds Professor of Law Emeritus at Stanford Law School. He is a graduate of Cornell University, Yale Law School, and Yale Graduate School (MA Political Science). He has a special interest in applying child development research to legal and public policies designed to help children and on issues related to implementation of public policies, His work has focused in particular on policies and practices related to child maltreatment, regulation of parenting, and improving outcomes for youth ages 14-25 who are disconnected from school and work. In both teaching and writing, he has collaborated frequently with faculty in other disciplines who are interested in these areas. Most recently, he was a member of the National Academy of Sciences Panel on Parenting that produced the volume Parenting Matters.
Professor Wald has also been involved in the drafting of major federal and state legislation regarding child welfare, including the Adoption Assistance and Child Welfare Act of 1980, and has served directly in a variety of government positions, including Executive Director of the San Francisco Department of Human Services and Deputy General Counsel of the U.S. Department of Health and Human Services, and as a member of the U.S. Advisory Board on Child Abuse and chair of the California State Advisory Committee on Child Abuse and Neglect. He also served as chair of WT Grant Faculty Scholars Selection Committee, on the board of directors of the Chapin Hall Children’s Center at the University of Chicago and on the boards of various legal organizations dedicated to helping children. -
Russell Wald
Executive Director of HAI, Institute for Human-Centered Artificial Intelligence (HAI)
BioRussell Wald serves as the Executive Director of the Stanford Institute for Human-Centered Artificial Intelligence (HAI). In this role he oversees HAI's research, education, finance and administrative activities, communications, industry programs, and policy and society hub. Wald works with HAI's co-directors and faculty leaders to help shape the strategic vision and human-centered mission of HAI. From 2020 - 2022 he served as HAI's first Director of Policy and later Managing Director for Policy and Society.
He is the co-author of various publications on AI including, Building a National AI Research Resource (2021), Enhancing International Cooperation in AI Research: The Case for a Multilateral AI Research Institute (2022), The Centrality of Data and Compute for AI Innovation: A Blueprint for a National Research Cloud (2022, Notre Dame Journal of Emerging Technologies). Currently he is part of a HAI seed grant research project titled, Addicted by Design: An Investigation of How AI-fueled Digital Media Platforms Contribute to Addictive Consumption. Additionally, he serves as a member of the AI Index Steering Committee, hosted by HAI.
Wald has held various policy program and government relations positions at Stanford University for over a decade. He also served as special assistant to Amy Zegart and Ashton Carter at Stanford's Center for International Security and Cooperation (CISAC). In 2014, he co-designed and led the inaugural Stanford congressional boot camp, and has since created numerous tech policy boot camps, establishing a strong and effective tradition of educating policymakers at Stanford and enhancing the collaboration between governments and academic institutions.
Prior to his work at Stanford, he held numerous roles with the Los Angeles World Affairs Council. He is a Visiting Fellow with the National Security Institute at George Mason University, and a former Term Member with the Council on Foreign Relations and the Truman National Security Project. Wald is a graduate of UCLA. -
Andrew G. Walder
Denise O'Leary & Kent Thiry Professor of the Humanities and Sciences and Senior Fellow at the Freeman Spogli Institute for International Studies and Professor, by courtesy, of Political Science
Current Research and Scholarly InterestsMarket reforms in China; and political movements in China during the Cultural Revolution.
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Ken Waldron
Professor (Research) of Mechanical Engineering, Emeritus
BioKenneth J. Waldron is Professor of Mechanical and Mechatronic Engineering at UTS. He is also Professor Emeritus from the Design Group in the Department of Mechanical Engineering of Stanford University. He holds bachelors and masters degrees from the University of Sydney, and PhD from Stanford. He works in machine design, and design methodology with a particular focus on robotic and mechatronic systems.
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Camille Walker
Program Associate, Science, Technology and Society
Current Role at StanfordProgram Associate, Science, Technology, and Society
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Christopher Alan Walker
Processing Archivist for the Archive of Recorded Sound, Archive of Recorded Sound
BioAs a Project Archivist I arrange and describe materials donated to the Archive of Recorded Sound in order to make them accessible for researchers.
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John J. Walker
Technology Administrator, JSK Journalism Fellowships
BioJohn J. Walker is technical administrator for the JSK Journalism Fellowships. His forward thinking nature makes JSK one of the most technologically adaptable programs on campus.
He manages all the software and digital infrastructure that keeps the fellowship running and accessible to applicants and collaborators from around the world and within the Stanford community. This includes the fellowship application platform, the JSK website and the various tools the program uses to communicate and collaborate.
John started working at Stanford in 1999. Previously he was web administrator for the Department of Communication and the technical director of the Political Communication Lab. There he created experimental manipulations for social science research, like testing people’s responses to political ads. Before Stanford, he worked at Sun Microsystems as a software developer.
John has a master’s degree in communication from Stanford, as well as master’s and bachelor’s degrees in computer science from the University of California at Riverside. -
Kimberly Walker
PROGRAM MANAGER, DEPT OF GRADUATE MEDICAL EDUC-SHC
Current Role at StanfordKim is Manager of the Instructional Design and Production group (EdTech) in the School of Medicine at Stanford University. She consults with SoM faculty to design and develop online, hybrid, and face-to-face courses for undergraduate, graduate and continuing medical education. Kim holds a Ph.D. and M.Ed. in Curriculum and Instruction with an emphasis in Instructional Design and Science Education from the University of South Florida. Her undergraduate degree is in biology from the University of Colorado. She formerly worked at Stanford Hospital as a Program Manager and Education Specialist in Graduate Medical Education.
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Rebecca D. Walker
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly InterestsInterests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration
