Stanford University
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Lacramioara Bintu
Associate Professor of Bioengineering
BioLacra Bintu is an Associate Professor of Bioengineering and a member of the Biophysics Program and Bio-X Institute at Stanford University. She earned undergraduate degrees in Physics, Mathematics, and Neuroscience from Brandeis University. As an undergraduate working with Jane Kondev and Rob Phillips, she used statistical mechanics to model transcription factor binding and gene regulation. She completed her Physics Ph.D. at U.C. Berkeley with Carlos Bustamante, where she used single-molecule approaches to study transcription on nucleosomal templates. As a postdoctoral scholar at Caltech with Michael Elowitz, she used live-cell microscopy to investigate chromatin-mediated gene regulation.
Her group seeks to discover fundamental principles of gene regulation and advance mammalian synthetic biology, with an emphasis on causal mechanisms, dynamic responses, and single-cell variability that enable signal integration at the population level. The lab develops tools to manipulate gene expression, for example by recruiting chromatin, transcriptional, or RNA regulators to defined genomic loci, or building DNA regulatory elements such as signal-responsive enhancers or silencers. To assess gene regulation responses at scale, the lab is using and developing new sequencing and imaging based techniques such as: delivery of large DNA libraries to cells coupled with sorting based on fluorescent and magnetic reporters, time-lapse fluorescence microscopy and in situ sequencing, or single-molecule footprinting of transcription factors and nucleosomes binding in live cells. Her group uses mathematical modeling to capture the fundamental principles underlying the observed gene expression responses and to predict new behaviors. This work provides insight into epigenetic mechanisms underlying development, cancer, and immune function and informs strategies for gene therapies that correct aberrant expression states.
Lacra lives in Menlo Park with her husband Anton and son Manu. They enjoy hiking, cooking, reading, playing board games, and watching birds in their backyard with their two cats. -
Biondo Biondi
Barney and Estelle Morris Professor
Current Research and Scholarly InterestsResearch
My students and I devise new algorithms to improve the imaging of reflection seismic data. Images obtained from seismic data are the main source of information on the structural and stratigraphic complexities in Earth's subsurface. These images are constructed by processing seismic wavefields recorded at the surface of Earth and generated by either active-source experiments (reflection data), or by far-away earthquakes (teleseismic data). The high-resolution and fidelity of 3-D reflection-seismic images enables oil companies to drill with high accuracy for hydrocarbon reservoirs that are buried under two kilometers of water and up to 15 kilometers of sediments and hard rock. To achieve this technological feat, the recorded data must be processed employing advanced mathematical algorithms that harness the power of huge computational resources. To demonstrate the advantages of our new methods, we process 3D field data on our parallel cluster running several hundreds of processors.
Teaching
I teach a course on seismic imaging for graduate students in geophysics and in the other departments of the School of Earth Sciences. I run a research graduate seminar every quarter of the year. This year I will be teaching a one-day short course in 30 cities around the world as the SEG/EAGE Distinguished Instructor Short Course, the most important educational outreach program of these two societies.
Professional Activities
2007 SEG/EAGE Distinguished Instructor Short Course (2007); co-director, Stanford Exploration Project (1998-present); founding member, Editorial Board of SIAM Journal on Imaging Sciences (2007-present); member, SEG Research Committee (1996-present); chairman, SEG/EAGE Summer Research Workshop (2006)
