Stanford University
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Leah B. Bushin
Assistant Professor of Chemistry
BioLeah Bushin is a chemical biologist and natural products chemist working at the interface of primary and secondary metabolism and leverages these insights to discover and produce novel natural products.
The Bushin research group will investigate novel metabolic pathways, enzymes, and bioactive molecules across all kingdoms of life, intending to repurpose them to address challenges in human health and environmental sustainability. Current efforts will primarily center on developing strategies for the efficient microbial production of compounds and materials at scale, as well as high-throughput approaches for engineering enzymes to perform synthetic reactions. More broadly, as the group designs and refines bioproduction platforms, they hope to deepen their fundamental understanding of cellular metabolism. With genome sequencing revealing an immense reservoir of untapped biosynthetic potential, their work aims to uncover and harness nature’s chemical diversity for drug discovery and synthetic derivatization. -
Lynette Cegelski
Monroe E. Spaght Professor of Chemistry and Professor, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsOur laboratory uncovers the chemical principles that organize living systems. Across biology - from microbial communities to human disease - chemical and macromolecular composition, molecular interactions, and chemical modifications govern the assembly, function, and persistence of complex biological systems, yet many of these principles remain hidden from conventional approaches. We develop innovative chemical, structural, and biological strategies to preserve and interrogate intact biological systems, revealing chemistry that cannot be observed by studying isolated components alone. Our work has uncovered previously unknown molecular structures, chemical modifications, and mechanisms of biological organization, including the discovery of phosphoethanolamine (pEtN) cellulose, a chemically modified form of cellulose that fundamentally changed our understanding of bacterial extracellular matrices.
In parallel, we discover and engineer molecules that probe, disrupt, and control biological systems. A major focus is the development of new strategies to combat antibiotic resistance and persistent bacterial communities. Our laboratory has introduced first-in-class vancomycin conjugates with multiple modes of action, unusually broad-spectrum activity, and the ability to sterilize biofilms - properties not observed together in other vancomycin conjugates. We also develop anti-biofilm agents, molecular probes, imaging agents, and other chemical tools that both reveal new biology and provide starting points for addressing pressing challenges in human health and disease.
Together, our research spans fundamental chemical discovery and molecular invention: uncovering the chemistry that enables biological systems to assemble and persist, and using those insights to create new ways to interrogate and control them. This work opens opportunities to combat infectious disease, improve human health, preserve marine ecosystems, advance sustainable materials, and deepen our understanding of how chemistry organizes life.
