Stanford University
Showing 51-60 of 75 Results
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Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program and Senior Fellow, by courtesy, at the Hoover Institution
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain. -
Rafael Pelayo, MD
Clinical Professor, Psychiatry and Behavioral Sciences - Sleep Medicine
Current Research and Scholarly InterestsSleep Disorders in Adults and Children
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Allison Tamara Siebern
Adjunct Clinical Associate Professor, Psychiatry and Behavioral Sciences - Sleep Medicine
BioDr. Allison Siebern, PhD, DAc, LAc, CBSM is a sleep medicine psychologist and neuroscience-based doctor of acupuncture specializing in sleep, mood, and neurological health. She is board certified in Behavioral Sleep Medicine by the American Board of Sleep Medicine.
Dr. Siebern is a pioneer in the field of integrative sleep health as she blends her training and expertise in neuroscience-based acupuncture, cognitive behavioral medicine, psychophysiology, near-infrared transcranial photobiomodulation and clinical neuroscience. Dr. Siebern's current integrative health research is on the intersection of scalp acupuncture and near-infrared transcranial photobiomodulation (tPBM) as neuromodulatory mechanisms to assist in improved symptom outcomes in neurodegenerative disorders and post-stroke recovery.
Dr. Siebern is currently a Sleep Medicine Psychologist and Behavioral Sleep Medicine Fellowship Track Director with the Durham VA Medical Center and the Director of Integrative Sleep Wake Health, PLLC. Dr. Siebern is an Adjunct Clinical Associate Professor at Stanford University School of Medicine in the Sleep Medicine Division where she completed the sleep fellowship from 2008 to 2010 and stayed on as full-time faculty until 2015 where she served as Associate Director and Co-Fellowship Training Director and then Director of the Behavioral Sleep Medicine Program. She has been treating patients of all ages in the field of sleep medicine for 15 years. She consults with companies on sleep and neurological health science, is published in peer-reviewed journals, has given talks at national conferences, and has been interviewed with many media outlets. Dr. Siebern has a passion for the field of sleep health and believes in the importance of training future generations of sleep providers.
