Stanford University
Showing 51-60 of 78 Results
-
Nnamdi Orakpo, MD, PhD
Clinical Assistant Professor, Psychiatry and Behavioral Sciences - Sleep Medicine
BioDr. Nnamdi Orakpo is a fellowship-trained sleep medicine specialist with Stanford Health Care. Dr. Orakpo is also a clinical assistant professor in the Department of Psychiatry and Behavioral Sciences, Division of Sleep Medicine at Stanford University School of Medicine.
Dr. Orakpo specializes in sleep medicine and sleep psychiatry. He focuses on sleep-related conditions, including chronic insomnia, narcolepsy, sleep apnea, restless leg syndrome, and trauma-associated sleep disorders. Dr. Orakpo also treats patients with ADHD, depression, anxiety disorders, neurocognitive disorders, and post-traumatic stress disorder. He offers interventional psychiatry treatments, including ketamine therapy and transcranial magnetic stimulation.
Dr. Orakpo led a pioneering study on virtual reality neurofeedback to treat insomnia and chronic centralized pain. He has also studied managing sleep apnea and obesity using GLP-1 medications. His other research has looked at the development of a rare movement disorder (propriospinal myoclonus) after taking metoclopramide during pregnancy.
Dr. Orakpo has published his research in peer-reviewed journals, including Sleep, Frontiers in Human Neuroscience, and Frontiers in Psychiatry. He co-wrote a clinical sleep medicine textbook with his colleagues, contributing chapters on chronic insomnia, isolated sleep paralysis, sleep-related eating disorders, sexsomnia, and exploding head syndrome. Dr. Orakpo has presented to his peers at international and national meetings of the World Sleep Congress/World Dentofacial Sleep Society, the American Academy of Neurology, and the American Public Health Association.
Dr. Orakpo is a member of many professional organizations, including the American Academy of Sleep Medicine, the American Psychiatric Association, the North American Neuromodulation Society, and the World Sleep Society. -
Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain. -
Rafael Pelayo, MD
Clinical Professor, Psychiatry and Behavioral Sciences - Sleep Medicine
Current Research and Scholarly InterestsSleep Disorders in Adults and Children
