Stanford University
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Edward Pimentel
Postdoctoral Scholar, Radiology
BioEdward Pimentel is a postdoctoral scholar in the lab of Prof. Tom Soh. After receiving his BS in Chemistry at BYU and pursuing the total synthesis of a natural product with anticancer activity in the lab of Dr. Merritt Andrus, Edward was the first graduate student in the lab of Dr. Jeffrey Martell, where his PhD work centered on using DNA nanostructures to accelerate catalytic reactions and building an ultrahigh-throughput DNA-encoded reaction screening platform. Now as a postdoctoral scholar, his research focuses on applying functional nucleic acids to solve problems in diagnostic and sensing for human health. In addition to his research, Edward is a passionate mentor and has been involved in mentoring programs at every stage of his career. He is now a coordinator for the SURPAS Someone Like Me Peer Mentoring program.
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Rebecca Pinals
Assistant Professor of Chemical Engineering
BioThe brain is a fascinatingly complex and delicate system of biomolecules, cells, and dynamic interactions that must be carefully maintained to support human health. When this balance is disrupted, disease can arise. Neurodegenerative dementias including Alzheimer’s disease are highly prevalent and profoundly devastating, yet remain largely untreatable or incurable.
The Pinals Lab engineers neuro-models and nano-tools to uncover mechanisms of neurodegenerative disease and intervene to halt—and even reverse—disease progression. A particular emphasis of our work is on the blood–brain barrier (BBB), the vascular interface that serves as the molecular gateway into the brain. We leverage human induced pluripotent stem cells (iPSCs) to build 3D cellular systems, providing a platform to recapitulate human brain properties and pathologies. In parallel, we design nanoparticles to report on real-time neurochemical processes, enabling unprecedented access to dynamic and spatially resolved biomolecular phenomena, and to modulate disease states. By integrating advanced human brain tissue models with rationally designed nanotechnologies, we aim to generate fundamental insights and tools that translate into meaningful impacts for human health.
