Bio-X
Showing 1,041-1,050 of 1,153 Results
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Kimberley Tolias
Professor (Research) of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsThe human brain is composed of billions of neurons connected through trillions of synapses that form the neural circuits underlying thought, emotion, learning, memory, and behavior. These synaptic connections are not static - they are continuously shaped and remodeled throughout life in response to experience, a processes critical for learning and memory. When neural circuits fail to develop or function properly, the consequences can be devastating, contributing to conditions ranging from autism spectrum disorder and intellectual disability to chronic pain, depression, schizophrenia, Alzheimer's disease, and cognitive decline.
Research in the Tolias laboratory seeks to understand the fundamental molecular and cellular mechanisms that govern how neural circuits form, adapt, and repair themselves in the mammalian central nervous system (CNS). Our work focuses on how neurons sense signals from their environment and convert them into intracellular signaling pathways that drive synapse formation and remodeling, dendritic and axonal growth, and cell migration. We are also interested in how disruption of these pathways contributes to neurological and neuropsychiatric disease, and whether targeting specific signaling mechanisms can promote recovery following CNS injury or disease.
The laboratory combines mouse genetics with molecular, cellular, biochemical, electrophysiological, genomic, and behavioral approaches to bridge fundamental neuroscience with translational discovery.
Current Research Areas:
- Molecular mechanisms regulating synapse development, neural circuit formation, and synaptic plasticity during learning and memory
- Roles of Rho GTPase signaling pathways in brain development, circuit remodeling, and neurological disease
- Functions of Adhesion-GPCRs in synapse development, dendritic and axonal growth, and neural circuit function
- Mechanisms underlying chronic pain, opioid tolerance, and chronic pain-associated mood and cognitive disorders
- Synaptic and circuit dysfunction following traumatic brain injury, radiotherapy, and other CNS injuries
- Development of new tools to visualize and map synaptic remodeling during learning and disease
- Interactions between the gut microbiome, brain development, neural circuit function, and behavior -
Natalie Torok
Professor of Medicine (Gastroenterology and Hepatology)
Current Research and Scholarly InterestsOur lab is focused on exploring the role of matrix remodeling in disease progression in metabolic dysfunction steatohepatitis (MASH)-related hepatocellular carcinoma and primary sclerosing cholangitis. Our goal is to uncover how biomechanical characteristics of the ECM affect mechano-sensation, and how these pathways could ultimately be targeted. We are also interested in aging and its effects on metabolic pathways in MASH and HCC.
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Brian Trippe
Assistant Professor of Statistics and, by courtesy, of Computer Science
BioDr. Brian Trippe is an assistant professor at Stanford in the Department of Statistics, with an affiliation in Stanford Data Science.
In his research, Dr. Trippe develops probabilistic machine learning methods to address challenges in biotechnology and medicine. Recently, his focus has been on generative modeling and inference algorithms for protein engineering.
Before joining Stanford, Dr. Trippe was a postdoctoral fellow at Columbia University in the Department of Statistics, and a visiting researcher at the Institute for Protein Design at the University of Washington. -
Philip S. Tsao, PhD
Professor (Research) of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsOur primary interests are in the molecular underpinnings of vascular disease as well as assessing disease risk. In addition to targeted investigation of specific signaling molecules, we utilize global genomic analysis to identify gene expression networks and regulatory units. We are particularly interested in the role of microRNAs in gene expression pathways associated with disease.
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Richard Tsien
George D. Smith Professor, Emeritus
Current Research and Scholarly InterestsWe study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.
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Jason Tucciarone, MD, PhD
Assistant Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology)
BioJason Tucciarone, MD, PhD is an Assistant Professor in the Department of Psychiatry and Behavioral Sciences at Stanford School of Medicine. A neuroscientist and psychiatrist, he leads a laboratory focused on uncovering the biological mechanisms of mental illness and developing novel therapies for mood disorders and addiction. His research centers on defining new cell types and evolutionarily conserved neural circuits involved in emotional processing, with the goal of identifying new therapeutic entry points. Using optogenetic, chemogenetic, neuroimaging, and behavioral approaches in mouse models of addiction, his lab investigates vulnerable brain circuitry underlying opioid use disorder. He also works and collaborates with the Depression Research Clinic, participating in academic and industry sponsored clinical trials investigating novel antidepressant therapies.
Clinically, Dr. Tucciarone works in Stanford’s Neuropsychiatry Clinic, where he treats patients with complex presentations at the interface of psychiatry and neurology, with particular interest in functional neurological disorders. He also sees a small cohort of psychotherapy patients in the Individual Psychotherapy Clinic and works shifts on Stanford’s inpatient psychiatry units.
Dr. Tucciarone completed his psychiatry training through Stanford’s Research Residency Track, where he conducted postdoctoral research under the supervision of Drs. Robert Malenka and Alan Schatzberg. During residency, his research examined neural circuits recruited during opioid withdrawal and explored strategies to enhance the anti-suicidal effects of ketamine through μ-opioid receptor partial agonism.
He received his bachelor’s degree in biology and philosophy from Union College, followed by three years as a Post-Baccalaureate IRTA fellow at the National Institute of Neurological Disorders and Stroke, where he developed MRI-reportable contrast agents to map neuronal connectivity. He then entered the Medical Scientist Training Program (MD/PhD) at Stony Brook University, completing his PhD in neuroscience under the mentorship of Dr. Josh Huang at Cold Spring Harbor Laboratory. His doctoral work used mouse genetic approaches to dissect excitatory and inhibitory cortical circuits, with a focus on chandelier interneurons in the prefrontal cortex.
In addition to his research and clinical work, Dr. Tucciarone is deeply committed to teaching and mentorship. During residency, he helped restructure neuroscience education for trainees and currently teaches introductory lectures on the neuroscience of addiction, PTSD, psychosis, and mood disorders. He leads resident group supervision in introductory psychodynamic psychotherapy and supervises undergraduates, medical students, residents, and clinical fellows in psychiatry clinics. -
Shripad Tuljapurkar
The Dean and Virginia Morrison Professor of Population Studies
Current Research and Scholarly InterestsStochastic dynamics of human and natural populations; prehistoric societies; probability forecasts including sex ratios, mortality, aging and fiscal balance; life history evolution.
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Minang (Mintu) Turakhia
Clinical Professor, Medicine
Current Research and Scholarly InterestsDr. Turakhia has an active clinical research program, with funding from AHA, VA, NIH, the medical device industry, and foundations. His research program aims to improve the treatment of heart rhythm disorders, with an emphasis on atrial fibrillation, by evaluating quality and variation of care, comparative and cost-effectiveness of therapies, and risk prediction. Dr. Turakhia has extensive expertise in using large administrative and claims databases for this work. His TREAT-AF retrospective study of over 500,000 patients with newly-diagnosed AF is the largest known research cohort of AF patients. He has served as study PI or chairman of several prominent single- and multicenter trials in atrial fibrillation, investigational devices for electrophysiology procedures, digital health interventions, and sensor technologies.
His other research interests include technology assessment of new device-based therapies and the impact of changing health policy and reform on the delivery of arrhythmia care. Dr. Turakhia is a Fellow of the American Heart Association, American College of Cardiology, and Heart Rhythm Society. -
Madeleine Udell
Assistant Professor of Management Science and Engineering and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsProfessor Udell builds the mathematical and computational foundations needed for
scalable, accessible, and responsible data-driven decisionmaking in high-stakes domains, with impact on challenges in healthcare, finance, marketing, operations, and engineering.
She develops new efficient algorithms to accelerate and automate optimization and data science, and new frameworks that empower users to invoke these algorithms and interpret the resulting decisions. -
Alexander Eckehart Urban
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
On Partial Leave from 06/01/2026 To 09/21/2026Current Research and Scholarly InterestsComplex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.