Wu Tsai Neurosciences Institute
Showing 31-40 of 71 Results
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Carla Shatz
Sapp Family Provostial Professor and Professor of Biology and of Neurobiology
Current Research and Scholarly InterestsThe goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.
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Kang Shen
Vincent V.C. Woo Director, Wu Tsai Neurosciences Institute, Frank Lee and Carol Hall Professor and Professor of Biology and of Pathology
Current Research and Scholarly InterestsThe connectivity of a neuron (its unique constellation of synaptic inputs and outputs) is essential for its function. Neuronal connections are made with exquisite accuracy between specific types of neurons. How each neuron finds its synaptic partners has been a central question in developmental neurobiology. We utilize the relatively simple nervous system of nematode C. elegans, to search for molecules that can specify synaptic connections and understand the molecular mechanisms of synaptic as
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Krishna Shenoy
Member, Bio-X
Current Research and Scholarly InterestsWe conduct neuroscience, neuroengineering and translational research to better understand how the brain controls movement, and to design medical systems to assist people with paralysis. These are referred to as brain-machine interfaces (BMIs), brain-computer interfaces (BCIs) and intra-cortical neural prostheses. We conduct this research as part of our Neural Prosthetic Systems Lab (NPSL) and our Neural Prosthetics Translational Lab (NPTL), which I co-direct with Prof. Jaimie Henderson, M.D.
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Laura Simons
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric)
Current Research and Scholarly InterestsI am a Professor in the Department of Anesthesiology, Perioperative, and Pain Medicine at Stanford University School of Medicine and a clinical psychologist who evaluates and treats youth presenting with chronic pain in the Pediatric Pain Management Clinic (PPMC) at Stanford Children’s Health. My program of research aims to utilize a pain neuroscience psychology approach to gain a mechanistic understanding of cognitive and affective processes in pediatric pain, perform rigorous patient-oriented research that translates targeted assessment into mechanistically informed treatment approaches for optimal clinical care and leverage the ubiquity of digital health to enhance patient access and reach. Central to these goals are projects targeting adolescence and youth adults with chronic pain that encompass defining brain signatures of threat interpretation, evaluating the efficacy of graded exposure (NCT03699007), deriving a biosignature of improvement vs. persistence of pain and disability (NCT04285112), and evaluating the impact of virtual reality on pain rehabilitation (NCT04636177). These studies along with additional work examining the journey of pain care for youth with pain and their parents form a comprehensive research portfolio in the realm of understanding and treating chronic pain in young people. My long-term career goal is to lead a robust research program focusing on alleviating the suffering of youth and emerging adults with chronic pain.
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Upinder Singh
Stanford Medicine Professor of Infectious Disease and Professor of Medicine (Infectious Diseases & Geographic Medicine), Emerita
Current Research and Scholarly InterestsOur lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.
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Melody Smith, MD, MS
Assistant Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
BioDr. Smith is a board-certified, fellowship-trained medical oncologist and hematologist. She is an Assistant Professor in the Department of Medicine within the Division of Blood & Marrow Transplantation and Cellular Therapy.
She is also a physician-scientist who conducts extensive research. As a medical student, she completed a fellowship at the National Institutes of Health (NIH) in the Clinical Research Training (now, the Medical Research Scholars) Program. Subsequently, after her clinical fellowship, she was a post-doctoral researcher at Memorial Sloan Kettering Cancer Center. Her lab's research focuses on studying the biology of chimeric antigen receptor (CAR) T cells to improve the therapy's efficacy and safety (1) by examining donor (Nature Medicine, 2017) and off-the-shelf CAR T cells in mouse models and (2) by investigating how the intestinal microbiome affects CAR T cell response (Nature Medicine, 2022).
Dr. Smith presents her research findings at regional, national, and international conferences. Additionally, she has co-authored articles on topics in cancer immunology, including cancer immunotherapy, stem cell transplantation, and CAR T cell therapy. Her work has been published in journals such as Nature, Nature Immunology, Nature Medicine, Blood, and Transplantation and Cellular Therapy. She serves as a peer reviewer for publications like NEJM Evidence, Science Advances, Blood, Cancer Cell, and Molecular Therapy. She has also contributed chapters to books, including Pocket Oncology, Current Concepts and Controversies in Hematopoietic Cell Transplantation, and Advanced Concepts in Human Immunology: Prospects for Disease Control.
She has received numerous honors; the American Society of Hematology, the American Society for Clinical Investigation, the Society for Immunotherapy of Cancer, the European Society for Blood and Marrow Transplantation, and several other professional organizations have recognized her achievements as a clinician, researcher, and scholar.
