Wu Tsai Neurosciences Institute
Showing 401-420 of 663 Results
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Daria Mochly-Rosen
George D. Smith Professor of Translational Medicine
Current Research and Scholarly InterestsTwo areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases.
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W. E. Moerner
Harry S. Mosher Professor and Professor, by courtesy, of Applied Physics
Current Research and Scholarly InterestsLaser spectroscopy and microscopy of single molecules to probe biological systems, one biomolecule at a time. Primary thrusts: fluorescence microscopy far beyond the optical diffraction limit (PALM/STORM/STED), methods for 3D optical microscopy in cells, and trapping of single biomolecules in solution for extended study. We explore protein localization patterns in bacteria, structures of amyloid aggregates in cells, signaling proteins in the primary cilium, and dynamics of DNA and RNA.
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Michelle Monje
Milan Gambhir Professor of Pediatric Neuro-Oncology and Professor, by courtesy, of Neurosurgery, of Pediatrics, of Pathology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsThe Monje Lab studies the molecular and cellular mechanisms of postnatal neurodevelopment. This includes microenvironmental influences on neural precursor cell fate choice in normal neurodevelopment and in disease states.
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Andrea Montanari
John D. and Sigrid Banks Professor and Professor of Mathematics
BioI am interested in developing efficient algorithms to make sense of large amounts of noisy data, extract information from observations, estimate signals from measurements. This effort spans several disciplines including statistics, computer science, information theory, machine learning.
I am also working on applications of these techniques to healthcare data analytics. -
Stephen B. Montgomery
Stanford Medicine Professor of Pathology, Professor of Genetics and of Biomedical Data Science and, by courtesy, of Computer Science
Current Research and Scholarly InterestsWe focus on understanding the effects of genome variation on cellular phenotypes and cellular modeling of disease through genomic approaches such as next generation RNA sequencing in combination with developing and utilizing state-of-the-art bioinformatics and statistical genetics approaches. See our website at http://montgomerylab.stanford.edu/
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Thomas Montine, MD, PhD
Stanford Medicine Professor of Pathology
BioDr. Montine is the Stanford Medicine Endowed Professor, Chair of Stanford Pathology Department, and member of the National Academy of Medicine. He received his education and medical training at Columbia University, McGill University, and Duke University, and was junior faculty at Vanderbilt University where he was awarded the Thorne Professorship. In 2002, Dr. Montine was appointed as the Alvord Endowed Professor in Neuropathology at the University of Washington where he was Director of the University of Washington Alzheimer’s Disease Research Center, one of the original 10 Centers in the US, and founding Director of the Pacific Udall Center, a NINDS-funded Center of Excellence for Parkinson’s Disease Research. Dr. Montine was Chair of the Department of Pathology at the University of Washington from 2010 to 2016 when he was appointed Chair of the Department of Pathology at Stanford University where he is the Stanford Medicine Endowed Professor.
The focus of the Montine Laboratory is on the structural and molecular bases of cognitive impairment. The Montine Laboratory addresses this prevalent, unmet medical need through a combination of neuropathology, biomarkers for detection and progression of early disease, and experimental studies that test hypotheses concerning specific mechanisms of neuron injury and then develop novel approaches to neuroprotection. Our current approaches include small molecule precision therapeutics and cell replacement strategies for brain. -
Tirin Moore
Ben Barres Professor
Current Research and Scholarly InterestsWe study neural circuit mechanisms of visual perception, cognition and sensorimotor integration.
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Elizabeth Mormino
Associate Professor (Research) of Neurology and Neurological Sciences (Neurology Research)
BioDr. Beth Mormino completed a PhD in Neuroscience at UC Berkeley in the laboratory of Dr. William Jagust, where she performed some of the initial studies applying Amyloid PET with the tracer PIB to clinically normal older individuals. This initial work provided evidence that the pathophysiological processes of Alzheimer’s disease begin years before clinical symptoms and are associated with subtle changes to brain regions critical for memory. During her postdoctoral fellowship with Drs. Reisa Sperling and Keith Johnson at Massachusetts General Hospital she used multimodal imaging techniques to understand longitudinal cognitive changes among individuals classified as preclinical AD. In 2017, Dr. Mormino joined the faculty at Stanford University in the department of Neurology and Neurological Sciences. Her research program focuses on combining imaging and genetics to predict cognitive trajectories over time, and the integration of novel PET scans to better understand human aging and neurodegenerative diseases.
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Michael Moseley
Professor of Radiology (Radiological Sciences Lab)
Current Research and Scholarly InterestsMR physics into tissue contrast mechanisms such as diffusion, perfusion, and functional imaging describes the research direction. Applications of cerebral stroke (brain attacks) and neurocognitive disorders are also being developed from these methods
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Heather E. Moss, MD, PhD
Professor of Ophthalmology and of Neurology and Neurological Sciences
Current Research and Scholarly InterestsI am a clinician scientist with a background in engineering, epidemiology and neuro-ophthalmology. In my research, I combine tools from these disciplines with the goal of understanding and preventing vision loss from optic nerve diseases. My focus is on papilledema, the swelling of the optic nerve head due to elevation in intracranial pressure, which we are characterizing using electrophysiological and imaging techniques. Other areas of interest are peri-operative vision loss and optic neuritis.
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Philippe Mourrain
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
BioExpertise: Neurobiology, Sleep sciences, Molecular Genetics, Developmental Biology, Gene Silencing/Epigenetics
Methodology: Synapse Imaging (Two photon microscopy, Array Tomography), Calcium Imaging (Light Sheet Microscopy/SPIM, Light Field Microscopy), Optogenetics, CLARITY, Tol2 transgenesis, TALENs, CRISPR/Cas9, Video tracking and behavior computation. -
Prithvi Mruthyunjaya, MD, MHS
Alan Adler Professor of Ophthalmology and Professor, by courtesy, of Radiation Oncology
Current Research and Scholarly InterestsDr Mruthyunjaya has maintained a broad research interest with publications in both ocular oncology and retinal diseases.
His focus is on multi-modal imaging of ocular tumors and understanding imaging clues that may predict vision loss after ocular radiation therapy. He coordinates multi-center research on the role of genetic testing and outcomes of treatments of ocular melanoma.
In the field of retinal diseases, his interests are in intra-operative imaging to enhance surgical accuracy. -
David Myung, MD, PhD
Associate Professor of Ophthalmology and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsNovel biomaterials to reconstruct the wounded cornea
Mesenchymal stem cell therapy for corneal and ocular surface regeneration
Engineered biomolecule therapies for promote corneal wound healing
Telemedicine in ophthalmology -
Claude M. Nagamine, DVM, PhD
Associate Professor of Comparative Medicine
Current Research and Scholarly InterestsMouse models to study murine and human infectious diseases. These colloborative studies include dengue virus, zika virus, adeno-associated virus, coxsackie virus, enterovirus 71, enterohepatic helicobacters, campylobacters, and anaplasma.
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William Newsome
Harman Family Provostial Professor and Professor of Neurobiology and, by courtesy, of Psychology
Current Research and Scholarly InterestsNeural processes that mediate visual perception and visually-based decision making. Influence of reward history on decision making.
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Quan Dong Nguyen, MD, MSc
Professor of Ophthalmology and, by courtesy, of Pediatrics and of Medicine (Immunology & Rheumatology)
Current Research and Scholarly InterestsWe have focused our research on the development of novel therapies and innovative assessment and diagnostic imaging technologies for retinal vascular and ocular inflammatory disorders, specifically diabetic retinopathy (DR), age-related macular degeneration (AMD) and uveitis. Building on our initial work describing the role of hypoxia and vascular endothelial growth factor (VEGF) in diabetic retinopathy (DR) and diabetic macular edema (DME), We have become interested in the biochemical mechanisms that would presumably lead to DME. During the past decade, our research has contributed to the body of evidences that defines the important role of anti-VEGF therapies in DME and AMD, as well as the role of the mTOR pathway and various interleukins in the pathogenesis of uveitis.
We have launched a productive and well-funded clinical research program while at the same time providing clinical care to patients with uveitis and retinal vascular diseases and fulfilling significant teaching and administrative assignments. We have established a number of key collaborators both within and outside the institutions. In addition, we have also established Center in Baltimore and now in Silicon Valley, which has excelled in conducting proof-of concept, early-phase multi-center clinical trials and studies, exploring the clinical disease manifestations and the efficacy of various pharmacologic agents in retinal, uveitic, and ocular inflammatory disorders. -
Anthony Norcia
Professor (Research) of Psychology, Emeritus
Current Research and Scholarly InterestsVision, development, functional imaging, systems analysis
