Vice Provost and Dean of Research
Showing 201-210 of 673 Results
-
Joseph Garner
Professor of Comparative Medicine and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsThe medical research community has long recognized that "good well-being is good science". The lab uses an integrated interdisciplinary approach to explore this interface, while providing tangible deliverables for the well-being of human patients and research animals.
-
Sergios Gatidis
Associate Professor of Radiology (Pediatric Radiology)
BioDr. Gatidis completed his medical training at the University of Tuebingen / Germany and received his Diploma in Mathematics from from the Universities of Tuebingen and Hagen / Germany. His research is focused on on methods and applications of machine learning for medical data analysis and translation of AI into clinical practice.
-
Brice Gaudilliere
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD) and, by courtesy, of Pediatrics (Neonatology)
Current Research and Scholarly InterestsThe advent of high dimensional flow cytometry has revolutionized our ability to study and visualize the human immune system. Our group combines high parameter mass cytometry (a.k.a Cytometry by Time of Flight Mass Spectrometry, CyTOF), with advanced bio-computational methods to study how the human immune system responds and adapts to acute physiological perturbations. The laboratory currently focuses on two clinical scenarios: surgical trauma and pregnancy.
-
Andrew Gentles
Associate Professor (Research) of Pathology, of Medicine (Computational Medicine) and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsComputational systems biology
-
Paul George, MD, PhD
Associate Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsDEVELOPMENT OF STROKE RECOVERY THERAPEUTICS:
Stroke is devastating to patients and their caregivers. We currently are investigating 3 neural repair approaches. The first focuses on developing a stroke recovery therapeutic based on an essential repair pathway and how it alters the immune response following stroke. The second utilizes implantable, conductive polymer devices to electrically manipulate the recovering nervous system to improve recovery and identify novel therapeutic targets. The final approach works to optimize stem cell therapeutics to enhance their ability to treat patients who have suffered from neural injury.
CONDUCTIVE BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration. Recent work utilizes these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes. -
Olivier Gevaert
Associate Professor of Medicine (Computational Medicine) and of Biomedical Data Science
Current Research and Scholarly InterestsMy lab focuses on biomedical data fusion: the development of machine learning methods for biomedical decision support using multi-scale biomedical data. We primarily use methods based on regularized linear regression to accomplish this. We primarily focus on applications in oncology and neuroscience.
-
William Giardino
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsWe aim to decipher the neural mechanisms underlying psychiatric conditions of stress, addiction, and sleep/circadian dysregulation. Our work uses combinatorial technologies for precisely mapping, monitoring, and manipulating neural circuits that regulate emotional states. We are especially focused on the behavioral functions of neuropeptide molecules acting throughout the circuitry of the extended amygdala- particularly in a brain region called the bed nucleus of the stria terminalis (BNST).
-
Erin Gibson
Assistant Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsGlia make up more than half of the cells in the human brain, but we are just beginning to understand the complex and multifactorial role glia play in health and disease. Glia are decidedly dynamic in form and function. Understanding the mechanisms underlying this dynamic nature of glia is imperative to developing novel therapeutic strategies for diseases of the nervous system that involve aberrant gliogenesis, especially related to changes in myelination.
-
Rona Giffard
Professor of Anesthesiology, Perioperative and Pain Medicine, Emerita
Current Research and Scholarly InterestsAstrocytes, microglia and neurons interact, and have unique vulnerabilities to injury based on their patterns of gene expression and their functional roles. We focus on the cellular and molecular basis of brain cell injury in stroke. We study the effects of altering miRNA expression, altering levels of heat shock and cell death regulatory proteins. Our goal is to improve outcome by improving mitochondrial function and brain cell survival, and reducing oxidative stress and inflammation.
