Amin Arbabian
Associate Professor of Electrical Engineering
Academic Appointments
-
Associate Professor, Electrical Engineering
-
Member, Bio-X
-
Member, Cardiovascular Institute
Honors & Awards
-
Tau Beta Pi Award for Excellence in Undergraduate Teaching, Stanford University (June 2016)
-
IEEE 2021 SSCS-Brain best paper award, IEEE (2022)
-
Best Paper Award, IEEE Transactions on BioCAS (T-BioCAS) (2020)
-
Best Paper Award, IEEE Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems (2016)
-
Best Paper Award, Progress in Electromagnetic Research Symposium (PIERS) (2015)
-
NSF CAREER Award, National Science Foundation (2015)
-
Best Paper Award, IEEE VLSI Circuits Symposium (2014)
-
Faculty Research Award, Google (2014)
-
Young Faculty Award (YFA), DARPA (2014)
-
Best Paper Award, IEEE International Conference in Ultra-Wideband (2013)
-
Hellman Faculty Scholar, Hellman Family Faculty Fund; Stanford University (2013)
-
School of Engineering Terman Fellow, Stanford University (2012)
-
Best Paper Award (2nd Place), IEEE Radio Frequency Integrated Circuits (RFIC) Symposium (2011)
-
Jack Kilby Outstanding Student Paper Award, IEEE International Solid-State Circuits Conference (2010)
-
Best Paper Award (2nd Place), IEEE Radio Frequency Integrated Circuits (RFIC) Symposium (2008)
Boards, Advisory Committees, Professional Organizations
-
Associate Editor, IEEE Solid-State Circuits Letters (2018 - Present)
-
Associate Editor, IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology (2017 - Present)
-
Member of steering committee, IEEE RFIC Symposium (2017 - Present)
Program Affiliations
-
Stanford SystemX Alliance
Professional Education
-
BSc, Sharif University of Technology, Electrical Engineering (2005)
-
MSc, UC Berkeley, Electrical Engineering and Computer Sciences (2007)
-
PhD, UC Berkeley, Electrical Engineering and Computer Sciences (2011)
Current Research and Scholarly Interests
My group's research covers circuit and system design for (1) biomedical, (2) sensing, and (3) Internet of Things (IoT) applications.
On the biomedical front we explore the design of emerging and hybrid medical imaging modalities and investigate new technologies for wireless implants, including ultrasonic power and data links.
Our work in sensing includes methods to enable next-generation interfaces (e.g., radar system design for human-computer interfaces), as well as methods of remote detection and imaging.
In the IoT area, we work on architectural solutions that enable radically miniaturized sensors for a trillion-sensor (tera-scale) future, including wireless power and wake-up radios. On the other end of the IoT space, we also work on next-generation extremely-high-throughput wireless and wireline “pipelines” that facilitate information flow on the network.
2024-25 Courses
- 3D+ Imaging Sensors
EE 119, EE 219 (Spr) - Understanding the Sensors in your Smartphone
EE 292S (Aut) -
Independent Studies (5)
- Special Studies and Reports in Electrical Engineering
EE 191 (Aut, Win, Spr, Sum) - Special Studies and Reports in Electrical Engineering
EE 391 (Aut, Win, Spr, Sum) - Special Studies and Reports in Electrical Engineering (WIM)
EE 191W (Aut, Sum) - Special Studies or Projects in Electrical Engineering
EE 190 (Aut, Win, Spr, Sum) - Special Studies or Projects in Electrical Engineering
EE 390 (Aut, Win, Spr, Sum)
- Special Studies and Reports in Electrical Engineering
-
Prior Year Courses
2023-24 Courses
- 3D+ Imaging Sensors
EE 119, EE 219 (Spr) - Fundamentals of Analog Integrated Circuit Design
EE 114, EE 214A (Aut) - Understanding the Sensors in your Smartphone
EE 292S (Aut)
2022-23 Courses
- 3D+ Imaging Sensors
EE 292Q (Spr) - Fundamentals of Analog Integrated Circuit Design
EE 114, EE 214A (Aut)
2021-22 Courses
- 3D+ Imaging Sensors
EE 292Q (Spr) - Fundamentals of Analog Integrated Circuit Design
EE 114, EE 214A (Aut)
- 3D+ Imaging Sensors
Stanford Advisees
-
Doctoral Dissertation Reader (AC)
Geneva Ecola, Junyi Wang -
Doctoral Dissertation Advisor (AC)
William Meng, Nikhil Poole -
Master's Program Advisor
Kevin Boateng, Sawyer Brundage, Joshuah Chen, Julia Du, Charlie Plonski, Raina Song, Patricia Strutz, Pablo Trejos Contreras, Spencer Wallace, Cornelia Wang, Liuxin Yang -
Doctoral (Program)
Mohammad Asadi, Deepak Gopalan, Thomas Horton King, Syamantak Payra, Kamyar Rajabali Fardi, Shubo Yang, Steven Yee, Megan Zeng
All Publications
-
Multi-Watt-Level 4.9-GHz Silicon Power Amplifier for Portable Thermoacoustic Imaging
IEEE JOURNAL OF SOLID-STATE CIRCUITS
2022
View details for DOI 10.1109/JSSC.2022.3149910
View details for Web of Science ID 000764854600001
-
A Data-Driven Waveform Adaptation Method for Mm-Wave Gait Classification at the Edge
IEEE SIGNAL PROCESSING LETTERS
2022; 29: 26-30
View details for DOI 10.1109/LSP.2021.3122355
View details for Web of Science ID 000745491900006
-
A 2x Time-Interleaved 28-GS/s 8-Bit 0.03-mm(2) Switched-Capacitor DAC in 16-nm FinFET CMOS
IEEE JOURNAL OF SOLID-STATE CIRCUITS
2021; 56 (8): 2335-2346
View details for DOI 10.1109/JSSC.2021.3057608
View details for Web of Science ID 000678340400004
-
CRADLE: Combined RF/Acoustic Detection and Localization of Passive Tags
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
2021; 68 (6): 2555-2568
View details for DOI 10.1109/TCSI.2021.3064990
View details for Web of Science ID 000655248200023
-
A Wireless Implantable Potentiostat for Programmable Electrochemical Drug Delivery
IEEE Biomedical Circuits and Systems (BIOCAS)
2021
View details for DOI 10.1109/BioCAS49922.2021.9644991
-
Effects of Reference Frequency Harmonic Spurs in FMCW Radar Systems
IEEE. 2021
View details for DOI 10.1109/RadaraConf2147009.2021.9455280
View details for Web of Science ID 000687846300138
-
Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-Based Therapeutic Drug Monitoring
IEEE JOURNAL OF SOLID-STATE CIRCUITS
2020; 55 (11): 2914–29
View details for DOI 10.1109/JSSC.2020.3020789
View details for Web of Science ID 000584274500007
-
Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-based Therapeutic Drug Monitoring.
IEEE journal of solid-state circuits
2020; 55 (11): 2914-2929
Abstract
In this paper, we present the design and the analysis of an electrochemical circuit for measuring the concentrations of therapeutic drugs using structure-switching aptamers. Aptamers are single-stranded nucleic acids, whose sequence is selected to exhibit high affinity and specificity toward a molecular target, and change its conformation upon binding. This property, when coupled with a redox reporter and electrochemical detection, enables reagent-free biosensing with a sub-minute temporal resolution for in vivo therapeutic drug monitoring. Specifically, we design a chronoamperometry-based electrochemical circuit that measures the direct changes in the electron transfer (ET) kinetics of a methylene blue reporter conjugated at the distal-end of the aptamer. To overcome the high-frequency noise amplification issue when interfacing with a large-size (> 0.25 mm2) implantable electrode, we present a sample-and-hold (S/H) circuit technique in which the desired electrode potentials are held onto noiseless capacitors during the recording of the redox currents. This allows disconnecting the feedback amplifiers to avoid its noise injection while reducing the total power consumption. A prototype circuit implemented in 65-nm CMOS demonstrates a cell-capacitance-insensitive input-referred noise (IRN) current of 15.2 pArms at a 2.5-kHz filtering bandwidth. We tested our system in human whole blood samples and measured the changes in the ET kinetics from the redox-labeled aptamers at different kanamycin concentrations. By employing principal component analysis (PCA) to compensate for the sampling errors, we report a molecular noise floor (at SNR = 1) of 3.1 µM with sub 1-sec acquisition time at 0.22-mW power consumption.
View details for DOI 10.1109/jssc.2020.3020789
View details for PubMedID 33343021
View details for PubMedCentralID PMC7742970
-
Inverse-designed non-reciprocal pulse router for chip-based LiDAR
NATURE PHOTONICS
2020
View details for DOI 10.1038/s41566-020-0606-0
View details for Web of Science ID 000521525600003
-
Time-of-flight imaging based on resonant photoelastic modulation (vol 58, pg 2235, 2019)
APPLIED OPTICS
2020; 59 (5): 1430
Abstract
This publisher's note corrects the Funding section in Appl. Opt.58, 2235 (2019)APOPAI0003-693510.1364/AO.58.002235.
View details for DOI 10.1364/AO.389202
View details for Web of Science ID 000526522300059
View details for PubMedID 32225397
-
Lithium Niobate Resonant Photoelastic Modulator for Time-of-Flight Imaging
IEEE. 2020
View details for Web of Science ID 000612090001179
-
Spatial Reconstruction of Soil Moisture Content using Non-Contact Thermoacoustic Imaging
IEEE. 2020
View details for Web of Science ID 000646236300082
-
A 10-Gbps Continuous-Time Linear Equalizer for mm-Wave Dielectric Waveguide Communication
IEEE SOLID-STATE CIRCUITS LETTERS
2020; 3: 266-269
View details for DOI 10.1109/LSSC.2020.3014859
View details for Web of Science ID 000723378200068
-
Resolution Enhanced Non-Contact Thermoacoustic Imaging using Coded Pulse Excitation
IEEE. 2020
View details for Web of Science ID 000635688900049
-
An Airborne Sonar System for Underwater Remote Sensing and Imaging
IEEE ACCESS
2020; 8: 189945–59
View details for DOI 10.1109/ACCESS.2020.3031808
View details for Web of Science ID 000584877300001
-
A Fully Integrated 32 Gbps 2x2 LoS MIMO Wireless Link with UWB Analog Processing for Point-to-Point Backhaul Applications
IEEE. 2020: 107–10
View details for Web of Science ID 000612019100027
-
A Cell-Capacitance-Insensitive CMOS Sample-and-Hold Chronoamperometric Sensor for Real-Time Measurement of Small Molecule Drugs in Whole Blood
IEEE. 2020: 406-+
View details for Web of Science ID 000570129800163
-
A Compact 14 GS/s 8-bit Switched-Capacitor DAC in 16 nm FinFET CMOS
IEEE. 2020
View details for Web of Science ID 000621657500004
-
Assessment of miniaturized ultrasound-powered implants: an in vivo study.
Journal of neural engineering
2020
Abstract
Therapeutic applications of implantable active medical devices have improved the quality of patient life. Numerous on-going research in the field of neuromodulation and bioelectronics medicine are exploring the use of these implants for treating diseases and conditions. Miniaturized implantable medical devices that are wirelessly powered by ultrasound (US) can be placed close to the target sites deep inside the body for effective therapy with less invasiveness. In this study, we assessed the long-term in vivo performance of miniaturized US powered implants (UPI) using a rodent model.Prototype UPI devices were implanted in rodents and powered wirelessly using an unfocused US transmitter over 12 weeks, and the corresponding device output was recorded. Structural integrity of UPI before and after implantation was studied using scanning electron microscopy (SEM). We also conducted qualitative histological assessment of skin and muscle surrounding the UPI and compared it to naïve control and US exposed tissues.We found that it is feasible to power UPI devices wirelessly with US over long-term. The encapsulation of UPIs did not degrade over time and the tissues surrounding the UPI were comparable to both naïve control and US exposed tissues.This study is the first to assess the long-term performance of miniaturized UPI devices using a rodent model over 12-weeks. The set of tests used in this study can be extended to assess other US-powered miniaturized implants.
View details for DOI 10.1088/1741-2552/ab6fc2
View details for PubMedID 31978913
-
Design of Large Effective Apertures for Millimeter Wave Systems Using a Sparse Array of Subarrays
IEEE TRANSACTIONS ON SIGNAL PROCESSING
2019; 67 (24): 6483–97
View details for DOI 10.1109/TSP.2019.2955828
View details for Web of Science ID 000502992600022
-
A Microwave-Induced Thermoacoustic Imaging System With Non-Contact Ultrasound Detection
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
2019; 66 (10): 1587–99
Abstract
Portable and easy-to-use imaging systems are in high demand for medical, security screening, nondestructive testing, and sensing applications. We present a new microwave-induced thermoacoustic imaging system with non-contact, airborne ultrasound (US) detection. In this system, a 2.7 GHz microwave excitation causes differential heating at interfaces with dielectric contrast, and the resulting US signal via the thermoacoustic effect travels out of the sample to the detector in air at a standoff. The 65 dB interface loss due to the impedance mismatch at the air-sample boundary is overcome with high-sensitivity capacitive micromachined ultrasonic transducers with minimum detectable pressures (MDPs) as low as 278 μ Pa rms and we explore two different designs-one operating at a center frequency of 71 kHz and another at a center frequency of 910 kHz. We further demonstrate that the air-sample interface presents a tradeoff with the advantage of improved resolution, as the change in wave velocity at the interface creates a strong focusing effect alongside the attenuation, resulting in axial resolutions more than 10× smaller than that predicted by the traditional speed/bandwidth limit. A piecewise synthetic aperture radar (SAR) algorithm modified for US imaging and enhanced with signal processing techniques is used for image reconstruction, resulting in mm-scale lateral and axial image resolution. Finally, measurements are conducted to verify simulations and demonstrate successful system performance.
View details for DOI 10.1109/TUFFC.2019.2925592
View details for Web of Science ID 000489765500004
View details for PubMedID 31251184
-
On-demand drug release from polypyrrole nanoparticulate films
AMER CHEMICAL SOC. 2019
View details for Web of Science ID 000525055501160
-
MINI-SPECIAL ISSUE ON 2018 INTERNATIONAL WORKSHOP ON INTEGRATED NONLINEAR MICROWAVE AND MILLIMETRE-WAVE CIRCUITS
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
2019; 67 (7): 2521–22
View details for DOI 10.1109/TMTT.2019.2919357
View details for Web of Science ID 000473597700008
-
Chromatic Properties of Blood During Coagulation.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
2019; 2019: 4733–36
Abstract
This paper proposes a method of detecting blood clots by analyzing the chromatic properties of blood. Measurements are performed with a Basler camera on blood during coagulation to determine the changes in red, green, and blue (RGB) values. Results show that there is a significant change in the red value that can be exploited for real-time, early detection of blood clots.
View details for DOI 10.1109/EMBC.2019.8856365
View details for PubMedID 31946919
-
Non-Invasive Remote Temperature Monitoring Using Microwave-Induced Thermoacoustic Imaging.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
2019; 2019: 6375–78
Abstract
Non-invasive temperature monitoring of tissue at depth in real-time is critical to hyperthermia therapies such as high-intensity focused ultrasound. Knowledge of temperature allows for monitoring treatment as well as providing real-time feedback to adjust deposited power in order to maintain safe and effective temperatures. Microwave-induced thermoacoustic (TA) imaging, which combines the conductivity/dielectric contrast of microwave imaging with the resolution of ultrasound, shows potential for estimating temperature non-invasively in real-time by indirectly measuring the temperature dependent parameters from reconstructed images. In this work, we study the temperature dependent behavior of the generated pressure in the TA effect and experimentally demonstrate simultaneous imaging and temperature monitoring using TA imaging. The proof-of-concept experiments demonstrate millimeter spatial resolution while achieving degree-level accuracy.
View details for DOI 10.1109/EMBC.2019.8857309
View details for PubMedID 31947301
-
Ultrasonic Wake-Up With Precharged Transducers
IEEE JOURNAL OF SOLID-STATE CIRCUITS
2019; 54 (5): 1475–86
View details for DOI 10.1109/JSSC.2019.2892617
View details for Web of Science ID 000466185400024
-
Time-of-flight imaging based on resonant photoelastic modulation
APPLIED OPTICS
2019; 58 (9): 2235–47
View details for DOI 10.1364/AO.58.002235
View details for Web of Science ID 000461903600013
-
An Aptamer-based Electrochemical-Sensing Implant for Continuous Therapeutic-Drug Monitoring in vivo
IEEE. 2019: C312–C313
View details for Web of Science ID 000531736500107
-
Ultrasonic Implant Localization for Wireless Power Transfer: Active Uplink and Harmonic Backscatter
IEEE. 2019: 818–21
View details for Web of Science ID 000510220100208
-
Multi-Access Networking with Wireless Ultrasound-Powered Implants
IEEE. 2019
View details for Web of Science ID 000521751500114
-
Chromatic Properties of Blood During Coagulation
IEEE. 2019: 4733–36
View details for Web of Science ID 000557295305038
-
Non-Invasive Remote Temperature Monitoring Using Microwave-Induced Thermoacoustic Imaging
IEEE. 2019: 6375–78
View details for Web of Science ID 000557295306183
-
Non-Contact Thermoacoustic Sensing and Characterization of Plant Root Traits
IEEE. 2019: 1992–95
View details for Web of Science ID 000510220100511
-
In Vivo Wireless Sensors for Gut Microbiome Redox Monitoring.
IEEE transactions on bio-medical engineering
2019
Abstract
A perturbed gut microbiome has recently been linked with multiple disease processes, yet researchers currently lack tools that can provide in vivo, quantitative, and real-time insight into these processes and associated host-microbe interactions. We propose an in vivo wireless implant for monitoring gastrointestinal tract redox states using oxidation-reduction potentials (ORP). The implant is powered and conveniently interrogated via ultrasonic waves. We engineer the sensor electronics, electrodes, and encapsulation materials for robustness in vivo, and integrate them into an implant that endures autoclave sterilization and measures ORP for 12 days implanted in the cecum of a live rat. The presented implant platform paves the way for long-term experimental testing of biological hypotheses, offering new opportunities for understanding gut redox pathophysiology mechanisms, and facilitating translation to disease diagnosis and treatment applications.
View details for DOI 10.1109/TBME.2019.2948575
View details for PubMedID 31634824
-
Beamforming Microwave-Induced Thermoacoustic Imaging for Screening Applications
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
2019; 67 (1): 464–74
View details for DOI 10.1109/TMTT.2018.2880901
View details for Web of Science ID 000455450200043
-
Ultrasonic Implant Localization for Wireless Power Transfer: Active Uplink and Harmonic Backscatter.
IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium
2019; 2019: 818–21
Abstract
Efficient ultrasonic power transfer to implantable devices requires precise transmitter beamforming to the receiver and can quickly degrade with small changes in implant location. Ultrasound localization can be used to find and track implants in the body to maintain an efficient link. We present a framework to calculate localization accuracy showing that sub-mm accuracy is obtainable using only three receive channels. A harmonic backscatter approach, which passively provides contrast in the frequency domain without active load modulation is compared to active uplink from the implant. The localization accuracy using both active uplink and harmonic backscatter from the implant power receiver is characterized using a linear array probe. The measured location standard deviation is nearly two orders of magnitude smaller than the half-power beamwidth of the array focal spot. Finally, beamforming using the measured location information increases the available power by over 20 × compared to an unfocused beam.
View details for PubMedID 31988699
-
Multi-Access Networking with Wireless Ultrasound-Powered Implants.
IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference
2019; 2019
Abstract
Multi-access networking with miniaturized wireless implantable devices can enable and advance closed-loop medical applications to deliver precise diagnosis and treatment. Using ultrasound (US) for wireless implant systems is an advantageous approach as US can beamform with high spatial resolution to efficiently power and address multiple implants in the network. To demonstrate these capabilities, we use wirelessly powered mm-sized implants with bidirectional communication links; uplink data communication measurements are performed using time, spatial, and frequency-division multiplexing schemes in tissue phantom. A 32-channel linear transmitter array and an external receiver are used as a base station to network with two implants that are placed 6.5 cm deep and spaced less than 1 cm apart. Successful wireless powering and uplink data communication around 100 kbps with a measured bit error rate below 10-4 are demonstrated for all three networking schemes, validating the multi-access networking feasibility of US wireless implant systems.
View details for DOI 10.1109/BIOCAS.2019.8919144
View details for PubMedID 31989118
-
Communication With Crystal-Free Radios
IEEE TRANSACTIONS ON COMMUNICATIONS
2018; 66 (10): 4513–20
View details for DOI 10.1109/TCOMM.2018.2840713
View details for Web of Science ID 000447853900012
-
End-to-End Design of Efficient Ultrasonic Power Links for Scaling Towards Submillimeter Implantable Receivers
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
2018; 12 (5): 1100–1111
Abstract
We present an analytical framework for optimizing the efficiency of ultrasonic wireless power links for implantable devices scaled down to sub-mm dimensions. Key design insights and tradeoffs are considered for various parameters including the operating frequency, the transmission depth, the size of the transmitter, the impedance and the aperture efficiency of the miniaturized receiver, and the interface between the receiver and the power recovery chain on the implant. The performance of spherically focused transducers as ultrasonic transmitters is analyzed to study the limits and the tradeoffs. Two optimization methods are presented: "Focal Peak" sets the focus of transducers at target depths, and "Global Maximum" maximizes the efficiency globally with off-focus operation. The results are also compared to phased array implementations. To investigate the efficiency of implants, miniaturized receivers made from single crystalline piezoelectric material, PMN-PT, are used as they have resonances in the derived optimal carrier frequency range (∼1-2 MHz). A methodology to achieve an efficient interface to the power electronics is then provided using an optogenetic stimulator as an example platform. The analytical results are verified through both simulations and measurements. Finally, an example ultrasonic link using a spherical transmitter with a radius of 2 cm is demonstrated; link efficiencies of 1.93-0.23% are obtained at 6-10 cm depths with sub-mm receivers for the optogenetic application.
View details for DOI 10.1109/TBCAS.2018.2871470
View details for Web of Science ID 000448529300001
View details for PubMedID 30235147
-
Long-term in vivo performance of novel ultrasound powered implantable devices.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
2018; 2018: 2985–88
Abstract
Neuromodulation devices have been approved for the treatment of epilepsy and seizures, with many other applications currently under research investigation. These devices rely on implanted battery powered pulse generators, that require replacement over time. Miniaturized ultrasound powered implantable devices have the potential to eliminate the need for batteries in neuromodulation devices. While these devices have been assessed in vitro, long-term in vivo assessment is required to determine device safety and performance. In this study, we developed a multi-stage long-term test platform to assess the performance of miniaturized ultrasound powered implantable devices.
View details for DOI 10.1109/EMBC.2018.8512978
View details for PubMedID 30441025
-
Thermal analysis of ultrasound-powered miniaturized implants: A tissue-phantom study.
The Journal of the Acoustical Society of America
2018; 143 (6): 3373
Abstract
Neurological implants that harvest ultrasound power have the potential to provide long-term stimulation without complications associated with battery power. An important safety question associated with long-term operation of the implant involves the heat generated by the interaction of the device with the ultrasound field. A study was performed in which the temperature rise generated by this interaction was measured. Informed by temperature data from thermocouples outside the ultrasound beam, a mathematical inverse method was used to determine the volume heat source generated by ultrasound absorption within the implant as well as the surface heat source generated within the viscous boundary layer on the surface of the implant. For the test implant used, it was determined that most of the heat was generated in the boundary layer, giving a maximum temperature rise 5 times that for absorption in an equivalent volume of soft tissue. This result illustrates that thermal safety guidelines based solely on ultrasound absorption of tissue alone are not sufficient. The method presented represents an alternative approach for quantifying ultrasound thermal effects in the presence of implants. The analysis shows a steady temperature rise of about 0.2°C for every 100 mW/cm2 for the presented test implant.
View details for PubMedID 29960486
-
Thermal analysis of ultrasound-powered miniaturized implants: A tissue-phantom study
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
2018; 143 (6): 3373-3382
View details for DOI 10.1121/1.5040470
View details for Web of Science ID 000437036000030
-
A mm-Sized Wireless Implantable Device for Electrical Stimulation of Peripheral Nerves
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
2018; 12 (2): 257–70
Abstract
A wireless electrical stimulation implant for peripheral nerves, achieving >10× improvement over state of the art in the depth/volume figure of merit, is presented. The fully integrated implant measures just 2 mm × 3 mm × 6.5 mm (39 mm3, 78 mg), and operates at a large depth of 10.5 cm in a tissue phantom. The implant is powered using ultrasound and includes a miniaturized piezoelectric receiver (piezo), an IC designed in 180 nm HV BCD process, an off-chip energy storage capacitor, and platinum stimulation electrodes. The package also includes an optional blue light-emitting diode for potential applications in optogenetic stimulation in the future. A system-level design strategy for complete operation of the implant during the charging transient of the storage capacitor, as well as a unique downlink command/data transfer protocol, is presented. The implant enables externally programmable current-controlled stimulation of peripheral nerves, with a wide range of stimulation parameters, both for electrical (22 to 5000 μA amplitude, ∼14 to 470 μs pulse-width, 0 to 60 Hz repetition rate) and optical (up to 23 mW/mm2 optical intensity) stimulation. Additionally, the implant achieves 15 V compliance voltage for chronic applications. Full integration of the implant components, end-to-end in vitro system characterizations, and results for the electrical stimulation of a sciatic nerve, demonstrate the feasibility and efficacy of the proposed stimulator for peripheral nerves.
View details for DOI 10.1109/TBCAS.2018.2799623
View details for Web of Science ID 000428547600001
View details for PubMedID 29578414
-
A Miniaturized Single-Transducer Implantable Pressure Sensor With Time-Multiplexed Ultrasonic Data and Power Links
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. 2018: 1089–1101
View details for DOI 10.1109/JSSC.2017.2782086
View details for Web of Science ID 000428676100014
- A mm-sized wireless implantable device for electrical stimulation of peripheral nerves IEEE Trans. Biomedical Circuits and Systems 2018
-
A Dual-Element VNA Electronic Calibration in CMOS
IEEE. 2018: 71–74
View details for Web of Science ID 000458440200021
-
A Single-Element VNA Electronic Calibration in CMOS
IEEE. 2018: 1304–7
View details for Web of Science ID 000451173600344
-
A Programmable RF Transmitter for Wideband Thermoacoustic Spectroscopic Imaging
IEEE. 2018: 1405–8
View details for Web of Science ID 000451173600371
-
Array Location Uncertainty in Imaging Radar: SAR vs. MIMO-SAR
IEEE. 2018: 150–53
View details for Web of Science ID 000467992900038
-
A 14.5mm(2) 8nW-59.7dBm-Sensitivity Ultrasonic Wake-Up Receiver for Power-, Area-, and Interference-Constrained Applications
IEEE. 2018: 454-+
View details for Web of Science ID 000459205600189
-
A 14.5mm(2) 8nW-59.7dBm-Sensitivity Ultrasonic Wake-Up Receiver for Power-, Area-, and Interference-Constrained Applications
IEEE. 2018
View details for Web of Science ID 000432256300188
-
Wireless Data Links for Next-Generation Networked Micro-Implantables
IEEE. 2018
View details for Web of Science ID 000434207400090
-
Microwave-Induced Thermoacoustic Imaging of Subcutaneous Vasculature With Near-Field RF Excitation
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
2018; 66 (1): 577–88
View details for DOI 10.1109/TMTT.2017.2714664
View details for Web of Science ID 000419544200052
- A miniaturized single-transducer implantable pressure sensor with time-multiplexed ultrasonic data and power links IEEE J. Solid-State Circuits 2018
-
Ball Grid Array Module With Integrated Shaped Lens for 5G Backhaul/Fronthaul Communications in F-Band
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
2017; 65 (12): 6380–94
View details for DOI 10.1109/TAP.2017.2755439
View details for Web of Science ID 000417885000019
-
Wireless Power Transfer to Millimeter-Sized Nodes Using Airborne Ultrasound
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
2017; 64 (10): 1526–41
Abstract
We propose the use of airborne ultrasound for wireless power transfer to mm-sized nodes, with intended application in the next generation of the Internet of Things (IoT). We show through simulation that ultrasonic power transfer can deliver 50 [Formula: see text] to a mm-sized node 0.88 m away from a ~ 50-kHz, 25-cm2 transmitter array, with the peak pressure remaining below recommended limits in air, and with load power increasing with transmitter area. We report wireless power recovery measurements with a precharged capacitive micromachined ultrasonic transducer, demonstrating a load power of 5 [Formula: see text] at a simulated distance of 1.05 m. We present aperture efficiency, dynamic range, and bias-free operation as key metrics for the comparison of transducers meant for wireless power recovery. We also argue that long-range wireless charging at the watt level is extremely challenging with existing technology and regulations. Finally, we compare our acoustic powering system with cutting edge electromagnetically powered nodes and show that ultrasound has many advantages over RF as a vehicle for power delivery. Our work sets the foundation for further research into ultrasonic wireless power transfer for the IoT.
View details for DOI 10.1109/TUFFC.2017.2737620
View details for Web of Science ID 000412634700010
View details for PubMedID 28796616
-
Exploiting spatial degrees of freedom for high data rate ultrasound communication with implantable devices
APPLIED PHYSICS LETTERS
2017; 111 (13)
View details for DOI 10.1063/1.5004967
View details for Web of Science ID 000412074000042
-
Peak-Power-Limited Frequency-Domain Microwave-Induced Thermoacoustic Imaging for Handheld Diagnostic and Screening Tools
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
2017; 65 (7): 2607-2616
View details for DOI 10.1109/TMTT.2016.2637909
View details for Web of Science ID 000405006300037
-
Remote sub-wavelength focusing of ultrasonically activated Lorentz current
APPLIED PHYSICS LETTERS
2017; 110 (16)
View details for DOI 10.1063/1.4981906
View details for Web of Science ID 000399984200068
-
Communication with Crystal-Free Radios
IEEE. 2017
View details for Web of Science ID 000428054301151
-
A Compact 130GHz Fully Packaged Point-to-Point Wireless System with 3D-Printed 26dBi Lens Antenna Achieving 12.5Gb/s at 1.55pJ/b/m
IEEE. 2017: 306
View details for Web of Science ID 000403393800127
-
A 30.5mm(3) Fully Packaged Implantable Device with Duplex Ultrasonic Data and Power Links Achieving 95kb/s with < 10(-4) BER at 8.5cm Depth
IEEE. 2017: 460
View details for Web of Science ID 000403393800194
-
The power of sound: miniaturized medical implants with ultrasonic links
SPIE-INT SOC OPTICAL ENGINEERING. 2017
View details for DOI 10.1117/12.2263877
View details for Web of Science ID 000411756000020
-
Closed-Loop Ultrasonic Power and Communication with Multiple Miniaturized Active Implantable Medical Devices
IEEE. 2017
View details for Web of Science ID 000416948401052
-
A High-Precision 36 mm(3) Programmable Implantable Pressure Sensor with Fully Ultrasonic Power-up and Data Link
IEEE. 2017: C104–C105
View details for Web of Science ID 000428759000042
-
Capsule Ultrasound Device: Characterization and Testing Results
IEEE. 2017
View details for Web of Science ID 000416948401038
-
Sound Technologies, Sound Bodies
IEEE MICROWAVE MAGAZINE
2016; 17 (12): 39-54
View details for DOI 10.1109/MMM.2016.2608638
View details for Web of Science ID 000388892900008
-
Design of Tunable Ultrasonic Receivers for Efficient Powering of Implantable Medical Devices With Reconfigurable Power Loads
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
2016; 63 (10): 1554-1562
Abstract
Miniaturized ultrasonic receivers are designed for efficient powering of implantable medical devices with reconfigurable power loads. Design parameters that affect the efficiency of these receivers under highly variable load conditions, including piezoelectric material, geometry, and operation frequency, are investigated. Measurements were performed to characterize electrical impedance and acoustic-to-electrical efficiency of ultrasonic receivers for off-resonance operation. Finally, we propose, analyze, and demonstrate adaptive matching and frequency tuning techniques using two different reconfigurable matching networks for typical implant loads from 10 [Formula: see text] to 1 mW. Both simulations and measurements show a significant increase in total implant efficiency (up to 50 percentage points) over this load power range when operating off-resonance with the proposed matching networks.
View details for DOI 10.1109/TUFFC.2016.2606655
View details for Web of Science ID 000385720000008
View details for PubMedID 27623580
-
Loss and Dispersion Limitations in mm-Wave Dielectric Waveguides for High-Speed Links
IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY
2016; 6 (4): 637-640
View details for DOI 10.1109/TTHZ.2016.2574326
View details for Web of Science ID 000384913500016
-
System-Level Analysis of Far-Field Radio Frequency Power Delivery for mm-Sized Sensor Nodes
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
2016; 63 (2): 300-311
View details for DOI 10.1109/TCSI.2015.2512720
View details for Web of Science ID 000372751000013
-
Capsule Ultrasound Device: Further Developments
IEEE. 2016
View details for Web of Science ID 000387497400478
-
Spatially Interleaved Architecture for High-Frequency Data Converters
IEEE. 2016: 1450-1453
View details for Web of Science ID 000390094701152
-
Extracting Dielectric Spectroscopic Properties from Microwave-Induced Thermoacoustic Signals
IEEE. 2016: 3618-3621
Abstract
Available data on the dielectric properties of biological tissue across a frequency range adds an extra degree of freedom of contrast besides the baseline structural information obtained by conventional imaging techniques. In this paper, we propose a new methodology to non-invasively extract the normalized effective conductivity of samples over a large frequency range using microwave-induced thermoacoustic (TA) signals. Additionally, a calibration approach has been adopted to remove the frequency dependency of the experimental setup errors as well as the RF power variation. The linear relationship between the TA signal amplitude on the absorbed microwave power is used to extract the properties of samples. Saline phantoms with various concentration are used to mimic different tissue materials in the proof-of-concept experiment. The extracted normalized effective conductivity by the proposed method matches the theoretical calculations as well as the direct contact measurements by a dielectric probe.
View details for Web of Science ID 000399823503238
View details for PubMedID 28269078
-
Microwave-Induced Thermoacoustic Tomography for Subcutaneous Vascular Imaging
IEEE. 2016
View details for Web of Science ID 000387497400270
-
Fast Iterative Reconstruction Algorithm for Microwave-Induced Thermoacoustic Imaging
IEEE. 2016: 1-4
View details for Web of Science ID 000401795900001
-
Analog Processing to Enable Scalable High-Throughput mm-Wave Wireless Fiber Systems
IEEE COMPUTER SOC. 2016: 1658-1662
View details for Web of Science ID 000406057400292
-
Standoff Tracking of Medical Interventional Devices using Non-Contact Microwave Thermoacoustic Detection
IEEE. 2016
View details for Web of Science ID 000390313200204
-
Noncontact thermoacoustic detection of targets embedded in dispersive media
SPIE-INT SOC OPTICAL ENGINEERING. 2016
View details for DOI 10.1117/12.2241941
View details for Web of Science ID 000391299100014
-
A Miniaturized Ultrasonically Powered Programmable Optogenetic Implant Stimulator System
IEEE. 2016: 12–14
View details for Web of Science ID 000381808900004
-
An Ultrasonically Powered Implantable Device for Targeted Drug Delivery
IEEE. 2016: 541–44
Abstract
A wirelessly powered implantable device is proposed for fully programmable and localized drug delivery. The implant is powered using an external ultrasonic transmitter and operates at <; 5% of the FDA diagnostic ultrasound intensity limit. Drug release is achieved through electrical stimulation of drug-loaded polypyrrole nanoparticles. A design methodology for the implant electronics is presented and experimentally demonstrated to be accurate in predicting the concentration of the released drug. To the best of our knowledge, this is the first ultrasonically powered implantable device platform for targeted drug delivery using electroresponsive polymers. The active area of the implant electronics is just 3 mm × 5 mm.
View details for Web of Science ID 000399823500133
View details for PubMedID 28324933
-
Fully packaged millimetre-wave dielectric waveguide with multimodal excitation
ELECTRONICS LETTERS
2015; 51 (17): 1339-1340
View details for DOI 10.1049/el.2015.2306
View details for Web of Science ID 000359725300021
-
A mm-Sized Implantable Medical Device (IMD) With Ultrasonic Power Transfer and a Hybrid Bi-Directional Data Link
IEEE JOURNAL OF SOLID-STATE CIRCUITS
2015; 50 (8): 1741-1753
View details for DOI 10.1109/JSSC.2015.2427336
View details for Web of Science ID 000358618500002
-
A Power-Harvesting Pad-Less Millimeter-Sized Radio
IEEE JOURNAL OF SOLID-STATE CIRCUITS
2015; 50 (4): 962-977
View details for DOI 10.1109/JSSC.2014.2384034
View details for Web of Science ID 000352156000013
-
Non-contact thermoacoustic detection of embedded targets using airborne-capacitive micromachined ultrasonic transducers
APPLIED PHYSICS LETTERS
2015; 106 (8)
View details for DOI 10.1063/1.4909508
View details for Web of Science ID 000350546600091
-
Capsule Ultrasound Device
IEEE. 2015
View details for DOI 10.1109/ULTSYM.2015.0168
View details for Web of Science ID 000366045700461
-
Interferogram-Based Breast Tumor Classification Using Microwave-Induced Thermoacoustic Imaging
IEEE. 2015: 2717-2720
Abstract
Microwave-induced thermoacoustic (TA) imaging combines the dielectric/conductivity contrast in the microwave range with the high resolution of ultrasound imaging. Lack of ionizing radiation exposure in TA imaging makes this technique suitable for frequent screening applications, as with breast cancer screening. In this paper we demonstrate breast tumor classification based on TA imaging. The sensitivity of the signal-based classification algorithm to errors in the estimation of tumor locations is investigated. To reduce this sensitivity, we propose to use the interferogram of received pressure waves as the feature basis used for classification, and demonstrate the robustness based on a finite-difference time-domain (FDTD) simulation framework.
View details for Web of Science ID 000371717202245
View details for PubMedID 26736853
-
Non-Contact Thermoacoustic Imaging of Tissue with Airborne Ultrasound Detection
IEEE. 2015
View details for DOI 10.1109/ULTSYM.2015.0264
View details for Web of Science ID 000366045700441
-
Design of High-Efficiency Miniaturized Ultrasonic Receivers for Powering Medical Implants with Reconfigurable Power Levels
IEEE. 2015
View details for DOI 10.1109/ULTSYM.2015.0215
View details for Web of Science ID 000366045700535
-
Stepped-frequency continuous-wave microwave-induced thermoacoustic imaging
APPLIED PHYSICS LETTERS
2014; 104 (22)
View details for DOI 10.1063/1.4879841
View details for Web of Science ID 000337161700093
-
Frequency-modulated magneto-acoustic detection and imaging
ELECTRONICS LETTERS
2014; 50 (11): 790-791
View details for DOI 10.1049/el.2014.0997
View details for Web of Science ID 000337911200006
- mm-Wave Silicon: Smarter, Faster, and Cheaper Communication and Imaging. Frequency References, Power Management for SoC, and Smart Wireless Interfaces Springer International Publishing. 2014: 281–295
-
A Compact Nonlinear-Transmission-Line-Based mm-Wave SFCW Imaging Radar
IEEE. 2014: 1766-1769
View details for Web of Science ID 000392912200432
-
A Compact Nonlinear-Transmission-Line-Based mm-Wave SFCW Imaging Radar
IEEE. 2014: 463-466
View details for Web of Science ID 000361020600112
-
Coherent Frequency-Domain Microwave-Induced Thermoacoustic Imaging
IEEE. 2014
View details for Web of Science ID 000363283700249
-
A power-harvesting pad-less mm-sized 24/60GHz passive radio with on-chip antennas
IEEE VLSI Circuits Symposium
2014
View details for DOI 10.1109/VLSIC.2014.6858380
-
Segmentation and Artifact Removal in Microwave-Induced Thermoacoustic Imaging
36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)
IEEE. 2014: 4747–4750
Abstract
Microwave-induced thermoacoustic (TA) imaging combines the soft-tissue dielectric contrast of microwave excitation with the resolution of ultrasound for the goal of a safe, high resolution, and possibly portable imaging technique. However, the hybrid nature of this method introduces new image-reconstruction challenges in enabling sufficient accuracy and segmentation. In this paper, we propose a segmentation technique based on the polarity characteristic of TA signals. A wavelet analysis based method is proposed to identify reflection artifacts as well. The time-frequency feature of the signal is used to assist differentiating artifacts. Ex vivo verification with experimental data is also provided.
View details for Web of Science ID 000350044704184
View details for PubMedID 25571053
-
A 135GHz SiGe Transmitter With A Dielectric Rod Antenna-In-Package For High EIRP/Channel Arrays
36th Annual IEEE Custom Integrated Circuits Conference (CICC) - The Showcase for Integrated Circuit Design in the Heart of Silicon Valley
IEEE. 2014
View details for Web of Science ID 000349122300144
-
A mm-Sized Implantable Device with Ultrasonic Energy Transfer and RF Data Uplink for High-Power Applications
36th Annual IEEE Custom Integrated Circuits Conference (CICC) - The Showcase for Integrated Circuit Design in the Heart of Silicon Valley
IEEE. 2014
View details for Web of Science ID 000349122300093
-
A 94 GHz mm-Wave-to-Baseband Pulsed-Radar Transceiver with Applications in Imaging and Gesture Recognition
Symposium on VLSI Circuits held its 26th Meeting on State-of-the-Art Topics important to VLSI Circuit and System Designers, as well as Device and Process Technology Experts
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. 2013: 1055–71
View details for DOI 10.1109/JSSC.2013.2239004
View details for Web of Science ID 000316810500017
- Analysis and Design of a Multi-mode Dielectric Waveguide Interconnect with Planar Excitation 2013
-
Analysis and Design of Multi-mode Dielectric Waveguide Interconnect with Planar Excitation
ELECTROMAGNETICS ACAD. 2013: 234-239
View details for Web of Science ID 000361384200047
- Dielectric Waveguide with Planar Multi-Mode Excitation for High Data-Rate Chip-to-Chip Interconnects 2013
- A Three-Stage Cascaded Distributed Amplifier with GBW Exceeding 1.5THz IEEE Radio Frequency Integrated Circuits Symposium (RFIC) 2012: 211-214
- A 94GHz mm-wave to baseband pulsed-radar for imaging and gesture recognition. In VLSI Circuits (VLSIC) 2012: 56-57
- 60GHz Low-Loss Compact Phase Shifters Using A Lumped Element Hybrid CICC 2011
-
Time-Domain Ultra-Wideband Synthetic Imager (TUSI) in Silicon
33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS)
IEEE. 2011: 505–511
Abstract
This paper introduces a silicon-based imaging array for remote measurements of complex permittivity of tissue. Using a coherent pulsed measurement approach, this time-frequency resolved technique recovers the three dimensional mapping of electrical properties of the subject in the microwave/millimeter-wave frequency spectrum. Some of the major challenges in the design of the system are described. Initial measurement results from the prototype high-resolution transmitter fabricated in a 0.13 μm SiGe process are described. The transmitter achieves pulse widths suitable for millimeter-level accuracy imaging.
View details for Web of Science ID 000298810000122
View details for PubMedID 22254359
- A 90GHz Pulsed-Transmitter with Near-Field/Far-Field Energy Cancellation using a Dual-Loop Antenna 2011
-
A 90 GHz Hybrid Switching Pulsed-Transmitter for Medical Imaging
IEEE JOURNAL OF SOLID-STATE CIRCUITS
2010; 45 (12): 2667-2681
View details for DOI 10.1109/JSSC.2010.2077150
View details for Web of Science ID 000285052300016
- A 90GHz Carrier 30GHz Bandwidth Hybrid Switching Transmitter with Integrated Antenna ISSCC 2010 Digest of Teach. 2010: 420-421
- Design of a CMOS Tapered Cascaded Multistage Distributed Amplifier IEEE Transactions on Microwave Theory and Techniques 2009; 57 (4): 938-947
- A 90nm CMOS Low-Power 60GH Transceiver with Integrated Baseband Circuitry ISSCC 2010 Digest of Tech. Papers 2009: 314-315
- A 90nm CMOS Low-Power 60GHz Transceiver with Integrated Baseband Circuitry IEEE Journal of Solid State Circuits 2009; 44 (12): 3434-3447
- A Tapered Cascaded Multi-Stage Distributed Amplifier with 370GHz GBW in 90nm CMOS 2008
- A Broadband Distributed Amplifier with Internal Feedback Providing 660GHz GBW in 90nm CMOS ISSCC 2008 Digest of Tech. Papers 2008: 196-197
- A 60-GHz 90- nm CMOS Cascode Amplifier with Interstage Matching 2007
- Internal Unilaterization Technique for CMOS mm-Wave Amplifiers 2007
- The Optimizations of PRF Staggering in a MTI Radar 2005
- Rural Telecommunications in Iran: A Hybrid Solution 2005
- Wireless Data Links for Next-Generation Networked Micro-Implantables Proc. 2018 IEEE Custom Integrated Circuits Conference 2018
- Scaling of Ultrasound-Powered Receivers for Sub-Millimeter Wireless Implants IEEE Biomedical Circuits and Systems Conference (BioCAS) 2017