Bio-X
Showing 901-950 of 1,059 Results
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Ivan Soltesz
James R. Doty Professor of Neurosurgery and Neurosciences
BioIvan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty. -
George Somero
David and Lucile Packard Professor in Marine Science, Emeritus
Current Research and Scholarly InterestsWe examine two aspects of organism-environment interactions: How does stress from physical (e.g., temperature) and chemical (oxygen levels, pH) factors perturb organisms and how do organisms respond, adaptively, to cope with this stress? We examine evolutionary adaptation and phenotypic acclimatization using a wide variety of marine animals, including Antarctic fishes and invertebrates from intertidal habitats on the coastlines of temperate and tropical seas.
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Geoffrey Sonn
Associate Professor of Urology and, by courtesy, of Radiology (Body MRI)
Current Research and Scholarly InterestsMy interest is in improving prostate cancer diagnosis through MRI and image-targeted prostate biopsy. In collaboration with radiologists at Stanford, we are working to define the optimal role of MRI in prostate cancer. We hope to improve cancer imaging to the point that some men with elevated PSA may safely avoid prostate biopsy. For those who need biopsy, we are evaluating novel MRI-US fusion targeted biopsy, a technique that greatly improves upon the conventional biopsy method.
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Justin L. Sonnenburg
Alex and Susie Algard Endowed Professor
Current Research and Scholarly InterestsThe goals of the Sonnenburg Lab research program are to (i) elucidate the basic mechanisms that underlie dynamics within the gut microbiota and (ii) devise and implement strategies to prevent and treat disease in humans via the gut microbiota. We investigate the principles that govern gut microbial community function and interaction with the host using a broad range of experimental approaches including studies of microbiomes in diverse human cohorts.
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Andrew Spakowitz
Tang Family Foundation Chair of the Department of Chemical Engineering, Professor of Chemical Engineering, of Materials Science and Engineering and, by courtesy, of Applied Physics
Current Research and Scholarly InterestsTheory and computation of biological processes and complex materials
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Erik Sperling
Associate Professor of Earth and Planetary Sciences, Senior Fellow at the Woods Institute for the Environment and Associate Professor, by courtesy, of Oceans
Current Research and Scholarly InterestsThe research interests in the Sperling Lab are Earth history and the evolution of life, and the interactions between the biosphere and the geosphere. As such this research can generally be considered paleontology, insofar as paleontology encompasses all aspects of the history of life.
Consequently, we define our research agenda by the questions we are interested in, rather than the tools used. This research incorporates multiple lines of evidence, and multiple tools, to investigate questions in the history of life. These lines of evidence include fossil data, molecular phylogenetics, sedimentary geochemistry, and developmental and ecological data from modern organisms. Ultimately, the goal is to link environmental change with organismal and ecological response through the lens of physiology.
Our field research takes place all over the world--current areas include:
-NW Canada (Yukon and Northwest Territories): Research has been conducted on the early Neoproterozoic Fifteenmile Group, Cryogenian and Ediacaran Windermere Supergroup, and on the Ordovician-Devonian Road River Group in the southern Richardson Mountains
-Southern Canadian Cordillera: Work here has focused on the early Cambrian Mural Formation and its soft-bodied fauna.
-England and Wales: Cambrian-Silurian successions in the Welsh Basin
-Namibia: Ediacaran Nama Group
-Upwelling zones: We study the oxygen minimum zone offshore California as an analogue for ancient low-oxygen oceans. -
David Spiegel
Jack, Lulu and Sam Willson Professor of Medicine
Current Research and Scholarly InterestsDr. Spiegel's research program involves mind/body interactions, including cancer progression, the response to traumatic stress, and the effect of hypnosis on the perception of pain and anxiety.
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Edda Spiekerkoetter
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly InterestsPulmonary Arterial Hypertension
Pulmonary Vascular Remodeling
Modulation of BMPR, ENG, ACVRL1 (ALK1), SMAD signaling
Structural and molecular programs governing right ventricular adaptation and failure
Hereditary Hemorrhagic Telangiectasia
Pulmonary Arteriovenous malformations
Computational Drug Prediction and Repurposing
Deep Tissue Confocal Imaging -
Daniel Spielman
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsMy research interests are in the field of medical imaging, particularly magnetic resonance imaging and in vivo spectroscopy. Current projects include MRI and MRS at high magnetic fields and metabolic imaging using hyperpolarized 13C-labeled MRS.
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Alfred M. Spormann
Professor of Civil and Environmental Engineering and of Chemical Engineering, Emeritus
Current Research and Scholarly InterestsMetabolism of anaerobic microbes in diseases, bioenergy, and bioremediation
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James Spudich
Douglass M. and Nola Leishman Professor of Cardiovascular Disease, Emeritus
Current Research and Scholarly InterestsThe general research interest of this laboratory is the molecular basis of cell motility, with a current emphasis on power output by the human heart. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement, changes in cell shape and muscle contraction.
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Randall Stafford
Professor of Medicine (Stanford Center for Research in Disease Prevention)
On Leave from 09/01/2024 To 01/31/2025Current Research and Scholarly InterestsAs Director of the SPRC Program on Prevention Outcomes and Practices, my work focuses on cardiovascular disease treatment and prevention, the adoption of new technology and practices, and patterns of physician practice, particularly medication prescribing. Specific interests include measuring and improving the quality of outpatient care, disparities in health care by race, gender, age and socioeconomic status, and interventions to improve prevention outcomes.
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Konstantina M. Stankovic, MD, PhD, FACS
Bertarelli Foundation Professor and Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsOur investigative efforts are organized along 3 research thrusts:
1. Vestibular schwannoma: uncovering mechanisms of sensorineural hearing loss (SNHL) and identifying better therapies;
2. High-resolution imaging of the inner ear;
3. Novel sensing of and therapies for SNHL.
Considering the complex and multifaceted nature of these challenges, our approach entails tailored solutions that integrate techniques from molecular biology, systems neuroscience, biotechnology, and otologic surgery. -
Creed Stary
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (MSD) and, by courtesy, of Ophthalmology
Current Research and Scholarly InterestsMechanisms promoting neuronal survival following cerebral ischemia-reperfusion injury; utilizing microRNA's to target multiple pathways to promote mitochondrial homeostasis and cell survival; anesthetic neurotoxicity; astrocyte-neuronal interaction
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Kristan Staudenmayer, MD, MS, FACS
Associate Professor of Surgery (General Surgery)
Current Research and Scholarly InterestsDefining the Impact of Injuries in the Elderly
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Tim Stearns
Professor of Biology
Current Research and Scholarly InterestsWe use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How do the centrosome and cilium control cell control cell signaling? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?
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Gary K. Steinberg, MD, PhD
Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology and Neurological Sciences
Current Research and Scholarly InterestsOur laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.
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Lawrence Steinman, MD
George A. Zimmermann Professor and Professor of Pediatrics
On Partial Leave from 07/18/2024 To 12/12/2024Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
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Lars Steinmetz
Dieter Schwarz Foundation Endowed Professor
Current Research and Scholarly InterestsThe Steinmetz lab develops genomic technologies to study the genetic basis of complex phenotypes, the mechanisms of gene regulation, and the molecular systems underpinning disease. We’re leveraging biological insights across scales and organisms to predict, diagnose, treat and ultimately prevent disease.
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David A. Stevens
Professor of Medicine, Emeritus
Current Research and Scholarly InterestsImmunology and chemotherapy of human fungal diseases, particularly coccidioidomycosis (Valley Fever) in California and aspergillosis, and the parasitic disease, trypanosomiasis.
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David Stevenson
Professor of Pediatrics (Genetics)
Current Research and Scholarly InterestsMy research focuses on disorders of the RAS/MAPK pathway (eg. NF1, Noonan, CFC, and Costello syndrome). I am working on understanding the impact of RAS signaling on the musculoskeletal system. I use genomic approaches to identify somatic events and modifiers in the RASopathies. I am also involved in identifying outcome measures for use in clinical trials for the associated orthopedic manifestations. Other areas of research involve vascular anomalies, Prader-Willi syndrome, and hypophosphatasia.
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David K. Stevenson, M.D.
Harold K. Faber Professor of Pediatrics and Professor, by courtesy, of Obstetrics and Gynecology and of Anesthesiology, Perioperative and Pain Medicine
On Partial Leave from 09/01/2024 To 08/31/2025Current Research and Scholarly InterestsOur research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. We are also study the causes of preterm birth and ways to prevent it.
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Aaron F. Straight
Pfeiffer and Herold Families Professor, Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsWe study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
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Thomas Sudhof
Avram Goldstein Professor in the School of Medicine, Professor of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
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Brian Suffoletto
Associate Professor of Emergency Medicine (Adult Clinical/Academic)
Current Research and Scholarly InterestsDr. Suffoletto is an emergency physician and NIH-funded investigator with a focus on collecting novel forms of longitudinal and remote data to inform temporal risk prediction and inform just-in-time adaptive interventions
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Edith Vioni Sullivan
Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
Current Research and Scholarly InterestsApplication of neuroimaging modalities and component process analysis of cognitive, sensory, and motor functions to identify brain structural and functional mechanisms disrupted in diseases affecting the brain: alcohol use disorder, HIV infection, dementia, and normal aging from adolescence to senescence.
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Yang Sun, MD, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in the role of inositol phosphatases in eye development and disease, using both animal models and human disease tissue. We are a translational laboratory seeking to understand the basic function of proteins as well as developing therapeutic strategies for clinical trials.
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Zijie Sun
Professor of Urology, Emeritus
Current Research and Scholarly InterestsWe focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.
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John B. Sunwoo, MD
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Dermatology
Current Research and Scholarly InterestsMy laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells; and (3) intra-tumor and inter-tumor heterogeneity.
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Trisha Suppes, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
Current Research and Scholarly InterestsLong-term treatment strategies for bipolar disorder, treatment for bipolar II disorder, use of treatment algorithms, and treatment of major depression.
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Yuri Suzuki
Stanley G. Wojcicki Professor, Professor of Applied Physics, and by courtesy, of Materials Science and Engineering
Current Research and Scholarly InterestsHer interests are focused on novel ground states and functional properties in condensed matter systems synthesized via atomically precise thin film deposition techniques with a recent emphasis has been on highly correlated electronic systems:
• Emergent interfacial electronic & magnetic phenomena through complex oxide heteroepitaxy
• Low dimensional electron gas systems
• Spin current generation, propagation and control in complex oxide-based ferromagnets
• Multifunctional behavior in complex oxide thin films and heterostructures -
Katrin J Svensson
Assistant Professor of Pathology
Current Research and Scholarly InterestsMolecular metabolism
Protein biochemistry
Cell biology and function
Animal physiology -
James Swartz
James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering
Current Research and Scholarly InterestsProgram Overview
The world we enjoy, including the oxygen we breathe, has been beneficially created by biological systems. Consequently, we believe that innovative biotechnologies can also serve to help correct a natural world that non-natural technologies have pushed out of balance. We must work together to provide a sustainable world system capable of equitably improving the lives of over 10 billion people.
Toward that objective, our program focuses on human health as well as planet health. To address particularly difficult challenges, we seek to synergistically combine: 1) the design and evolution of complex protein-based nanoparticles and enzymatic systems with 2) innovative, uniquely capable cell-free production technologies.
To advance human health we focus on: a) achieving the 120 year-old dream of producing “magic bullets”; smart nanoparticles that deliver therapeutics or genetic therapies only to specific cells in our bodies; b) precisely designing and efficiently producing vaccines that mimic viruses to stimulate safe and protective immune responses; and c) providing a rapid point-of-care liquid biopsy that will count and harvest circulating tumor cells.
To address planet health we are pursuing biotechnologies to: a) inexpensively use atmospheric CO2 to produce commodity biochemicals as the basis for a new carbon negative chemical industry, and b) mitigate the intermittency challenges of photovoltaic and wind produced electricity by producing hydrogen either from biomass sugars or directly from sunlight.
More than 25 years ago, Professor Swartz began his pioneering work to develop cell-free biotechnologies. The new ability to precisely focus biological systems toward efficiently addressing new, “non-natural” objectives has proven tremendously useful as we seek to address the crucial and very difficult challenges listed above. Another critical feature of the program is the courage (or naivete) to approach important objectives that require the development and integration of several necessary-but- not-sufficient technology advances. -
Karl G. Sylvester
Professor of Surgery (Pediatric Surgery)
Current Research and Scholarly InterestsScholarly interests include investigation of molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include common conditions of pregnancy, gut microbial ecology and Necrotizing Enterocolitis (NEC).
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Daniel Sze, MD, PhD
Professor of Radiology (Interventional Radiology)
Current Research and Scholarly InterestsTransarterial administration of chemotherapeutics, radioactive microspheres, and biologics for the treatment of unresectable tumors; management of portal hypertension and complications of cirrhosis (TIPS); treatment of complications of organ transplantation; Venous and pulmonary arterial thrombolysis and reconstruction; Stent and Stent-graft treatment of peripheral vascular diseases, aneurysms, aortic dissections
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Christopher N. Ta, MD
Professor of Ophthalmology
BioChristopher N. Ta, MD specializes in the diagnosis and medical treatment of cornea diseases. His areas of expertise are in the treatment of ocular infections, inflammation, dry eyes and ocular surface diseases. He has conducted numerous clinical trials toward the prevention and treatment of ocular infections. Dr. Ta also has extensive clinical experience in the treatment of ocular graft-versus host disease following hematopoietic stem cell transplantation.
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William Talbot
Mary and Dr. Salim Shelby Professor
Current Research and Scholarly InterestsWe use genetic and cellular approaches to investigate the molecular basis of glial development and myelination in the zebrafish.
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Longzhi Tan
Assistant Professor of Neurobiology
Current Research and Scholarly InterestsThe Tan Lab studies the single-cell 3D genome architectural basis of neurodevelopment and aging by developing the next generation of in vivo multi-omic assays and algorithms, and applying them to the human and mouse cerebellum.
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Hua Tang
Professor of Genetics and, by courtesy, of Statistics
Current Research and Scholarly InterestsDevelop statistical and computational methods for population genomics analyses; modeling human evolutionary history; genetic association studies in admixed populations.
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Jean Y. Tang MD PhD
Professor of Dermatology
On Partial Leave from 10/07/2024 To 10/06/2025Current Research and Scholarly InterestsMy research focuses on 2 main areas:
1. Skin cancer:
- New therapeutics to treat and prevent non-melanoma skin cancer, especially by targeting the Hedgehog signaling pathway for BCC tumors
- Genomic analysis of drug-resistant cancers
- Identifying risk factors for skin cancer in the Women's Health Initiative
2. Epidermolysis Bullosa: gene therapy and protein therapy to replace defective/absent Collagen 7 in children and adults with Recessive Dystrophic EB -
Sindy Tang
Associate Professor of Mechanical Engineering, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Radiology and of Bioengineering
Current Research and Scholarly InterestsThe long-term goal of Dr. Tang's research program is to harness mass transport in microfluidic systems to accelerate precision medicine and material design for a future with better health and environmental sustainability.
Current research areas include: (I) Physics of droplets in microfluidic systems, (II) Interfacial mass transport and self-assembly, and (III) Applications in food allergy, single-cell wound repair, and the bottom-up construction of synthetic cell and tissues in close collaboration with clinicians and biochemists at the Stanford School of Medicine, UCSF, and University of Michigan.
For details see https://web.stanford.edu/group/tanglab/ -
William Abraham Tarpeh
Assistant Professor of Chemical Engineering, by courtesy, of Civil and Environmental Engineering and Center Fellow, by courtesy, at the Woods Institute for the Environment
BioReimagining liquid waste streams as resources can lead to recovery of valuable products and more efficient, less costly approaches to reducing harmful discharges to the environment. Pollutants in effluent streams can be captured and used as valuable inputs to other processes. For example, municipal wastewater contains resources like energy, water, nutrients, and metals. The Tarpeh Lab develops and evaluates novel approaches to resource recovery from “waste” waters at several synergistic scales: molecular mechanisms of chemical transport and transformation; novel unit processes that increase resource efficiency; and systems-level assessments that identify optimization opportunities. We employ understanding of electrochemistry, separations, thermodynamics, kinetics, and reactor design to preferentially recover resources from waste. We leverage these molecular-scale insights to increase the sustainability of engineered processes in terms of energy, environmental impact, and cost.
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Daniel Tartakovsky
Professor of Energy Science Engineering
Current Research and Scholarly InterestsEnvironmental fluid mechanics, Applied and computational mathematics, Biomedical modeling.
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Peter Tass
Professor of Neurosurgery
BioDr. Peter Tass investigates and develops neuromodulation techniques for understanding and treating neurologic conditions such as Parkinson’s disease, epilepsy, dysfunction following stroke and tinnitus. He creates invasive and non-invasive therapeutic procedures by means of comprehensive computational neuroscience studies and advanced data analysis techniques. The computational neuroscience studies guide experiments that use clinical electrophysiology measures, such as high density EEG recordings and MRI imaging, and various outcome measures. He has pioneered a neuromodulation approach based on thorough computational modelling that employs dynamic self-organization, plasticity and other neuromodulation principles to produce sustained effects after stimulation. To investigate stimulation effects and disease-related brain activity, he focuses on the development of stimulation methods that cause a sustained neural desynchronization by an unlearning of abnormal synaptic interactions. He also performs and contributes to pre-clinical and clinical research in related areas.
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Vivianne Tawfik
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain)
Current Research and Scholarly InterestsMy overall research interest is to understand how the immune system interacts with the nervous system after injury to promote the transition from acute to chronic pain. In my clinical practice I care for patients with persistent pain that often occurs after minor trauma such as fracture or surgery. Using basic science approaches including whole system immune phenotyping with mass cytometry and genetic manipulation of peripheral and central immune cells, we seek to dissect the temporal and tissue-specific contribution of these cells to either promotion or inhibition of healing.
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Joyce Teng, MD, PhD
Professor of Dermatology and, by courtesy, of Pediatrics
BioJoyce Teng, MD, PhD is a professor in dermatology at Stanford University. She is affiliated with multiple hospitals in the area, including Lucile Salter Packard Children's Hospital (LPCH) at Stanford and Stanford Hospital and Clinics (SHC). She received her medical degree from Vanderbilt University School of Medicine and has been in practice for more than 12 years. She is one of the 6 pediatric dermatologists practicing at LPCH and one of 72 at SHC who specialize in Dermatology. She sees patients with rare genetic disorders, birthmarks, vascular anomalies and a variety of inflammatory skin diseases. She is also an experienced pediatric dermatological surgeon. Her research interests are drug discovery and novel therapy for skin disorders.
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Avnesh Thakor
Associate Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly InterestsInterventional Radiologists can access almost any part of the human body without the need for conventional open surgical techniques. As such, they are poised to change the way patients can be treated, given they can locally deliver drug, gene, cell and cell-free therapies directly to affected organs using image-guided endovascular, percutaneous, endoluminal, and even using device implantation approaches
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Suzanne Tharin
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsThe long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
