Wu Tsai Neurosciences Institute
Showing 1-14 of 14 Results
Thomas Rando, MD, PhD
Professor of Neurology
Current Research and Scholarly InterestsOur laboratory studies the molecular mechanisms regulating stem cell function, the effects of aging on skeletal muscle and skeletal muscle stem cells, and the pathogenesis and experimental therapeutics for hereditary muscle diseases, specifically the muscular dystrophies.
Director for Planning and Operations
Director for Planning and Operations, Wu Tsai Neurosciences Institute
BioDr. Raschke is the founding Director for Planning and Operations of the Wu Tsai Neurosciences Institute. She serves as a member of the Executive Committee, and has built the institute starting from its inception in 2014. Dr. Raschke directs all institute grant, community building and neuroscience community lab programs, as well as institute operations. She was instrumental in the design and construction of the research complex comprised of the Stanford Neurosciences and ChEM-H Buildings dedicated in 2020. She has a PhD in Molecular and Cell Biology from UC Berkeley. Prior to joining Wu Tsai Neuro, Dr. Raschke was the Associate Director of Information Technology for Stanford Bio-X. She was a postdoc with Michael Levitt in the Department of Structural Biology at Stanford, and a graduate student with Susan Marqusee in the Department of Molecular and Cell Biology at UC Berkeley.
Natalie L. Rasgon
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine) at the Stanford University Medical Center
Current Research and Scholarly InterestsDr. Rasgon has been involved in longitudinal placebo-controlled neuroendocrine studies for nearly two decades, and she has been involved in neuroendocrine and brain imaging studies of estrogen effects on depressed menopausal women for the last eight years. It should be noted that in addition to her duties as a Professor of Psychiatry and Obstetrics & Gynecology, Dr. Rasgon is also the Director of the Behavioral Neuroendocrinology Program and of the Women's Wellness Program.
Jennifer L. Raymond
Professor of Neurobiology
Current Research and Scholarly InterestsWe study the neural mechanisms of learning, using a combination of behavioral, neurophysiological, and computational approaches. The model system we use is a form of cerebellum-dependent learning that regulates eye movements.
Lawrence Recht, MD
Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly InterestsOur laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.
Richard J. Reimer, MD
Associate Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology at the Palo Alto Veterans Administration Health Care System
Current Research and Scholarly InterestsReimer Lab interests
A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.
A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders.
Allan L. Reiss
Howard C. Robbins Professor of Psychiatry and Behavioral Sciences and Professor of Radiology
Current Research and Scholarly InterestsMy laboratory, the Center for Interdisciplinary Brain Sciences Research (CIBSR), focuses on multi-level scientific study of individuals with typical and atypical brain structure and function. Data are obtained from genetic analyses, structural and functional neuroimaging studies, assessment of endocrinological status, neurobehavioral assessment, and analysis of pertinent environmental factors. Our overarching focus is to model how brain disorders arise and to develop disease-specific treatments.
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsThe auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.
Associate Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
BioDr. Carolyn Rodriguez leads studies investigating the brain basis of severe mental disorders. Her landmark clinical trials pioneer rapid-acting treatments for illnesses including Obsessive-Compulsive Disorder (OCD). As the Director of the Translational Therapeutics Lab and Associate Professor in the Department of Psychiatry and Behavioral Sciences, Dr. Rodriguez has developed methods that combine in vivo drug infusions with magnetic resonance spectroscopy, functional magnetic resonance imaging, and electroencephalograpy to map human brain circuit dysfunction in real time.
As a psychiatrist, neuroscientist, and clinical researcher, Carolyn’s NIH-, foundation-, and donor-funded mechanistic and clinical efficacy studies span targeted glutamatergic and opioid pathway pharmacotherapy, non-invasive brain stimulation, and psychotherapy for OCD, PTSD, and hoarding disorder. Additional studies focus on understanding the basic neuroscience mechanisms of repetitive behaviors. Carolyn also provides mental health care for Veterans as a consultation-liaison psychiatrist at the Palo Alto Veterans Affairs.
Carolyn serves as Associate Chair for Inclusion and Diversity in the Department of Psychiatry at Stanford, Deputy Editor of The American Journal of Psychiatry, Vice Chair for the Research Council of the American Psychiatric Association, and Co-Chair of the International OCD Foundation Research Symposium. She has won several national awards, including the Presidential Early Career Award for Scientists and Engineers (PECASE). The PECASE recognizes investigators who are pursuing bold and innovative projects at the early stages of their careers and is considered one of the highest honors in scientific research. Carolyn presented her research at the World Economic Forum in Davos, and her work has been highlighted by organizations including NPR, PBS, New York Times, ABC News, NBC News, Newsweek, and Time.com. She contributes articles to Harvard Business Review and Huffington Post to share scientific findings with the public.
Carolyn received her B.S. in Computer Science from Harvard University, followed by a Ph.D. in Neuroscience and Genetics from Harvard Medical School and an M.D. from Harvard Medical School-M.I.T. Born in San Juan, Puerto Rico, she now lives with her husband and three children in Palo Alto.
Associate Professor of Biochemistry and of Medicine (Oncology)
Current Research and Scholarly Intereststhe overall goal of my laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states, and to devise new strategies to repair their function.
Professor of Orthopaedic Surgery at the Lucile Salter Packard Children's Hospital and the Stanford University Medical Center
Current Research and Scholarly InterestsDr. Rose's research investigates early brain and motor development in preterm children and neuromuscular mechanisms underlying cerebral palsy (CP). Research examines neonatal microstructural brain development on DTI and physiological correlates of motor function in preterm children. Dr. Rose served on the NIH Taskforce on Childhood Motor Disorders, the AACPDM Research Committee and Steering Committee to develop CDE for CP neuroimaging diagnostics, and serves on the Board of Directors of SBMT.
Professor of Otolaryngology-Head and Neck Surgery and of Radiology (Molecular Imaging Program at Stanford)
BioEben Rosenthal is a surgeon-scientist and academic leader. He is currently serving as the John and Ann Doerr Medical Director of the Stanford Cancer Center, a position he has held since July 2015. He works collaboratively with the Stanford Cancer Institute and Stanford Health Care leaders to set the strategy for the clinical delivery of cancer care across Stanford Medicine and growing cancer networks.
Before coming to Stanford, he learned his surgical skills in otolaryngology from the University of Michigan and traveled west for further training in facial plastic and reconstructive surgery at the Oregon Health and Science University. He joined the faculty at University of Alabama at Birmingham where he started as an Assistant Professor of Surgery within the Division of Otolaryngology. In 2012, Dr. Rosenthal became Division Director of Otolaryngology – Head and Neck Surgery and the holder of the John S. Odess Endowed Chair at the University of Alabama at Birmingham. He moved to Stanford in 2015 to become the Ann and John Doerr Medical Director of the Stanford Cancer Center.
Dr. Rosenthal is certified by the American Board of Otolaryngology and is a Diplomat of the American Board of Facial Plastic and Reconstructive Surgery. He specializes in the treatment and reconstruction of head and neck cancer patients. He has a strong interest in development of new strategies to surgically repair complex head and neck defects to improve functional and cosmetic outcomes.
He has published over 160 peer-reviewed scientific manuscripts, authored many book chapters and published a book on optical imaging in cancer. He is on the editorial board of Head & Neck and The Laryngoscope and is also a charter member of the NIH Developmental Therapeutics Study Section. Dr. Rosenthal has performed preclinical and clinical research on the role of targeted therapies for use to treat cancer alone and in combination with conventional therapy. He has served as principal investigator on several early phase investigator-initiated and industry sponsored clinical trials in molecular oncology. He has received grant funding from the American Cancer Society, NIH/NCI and NIH/NIDCR to study the role of targeted therapy and novel imaging strategies in cancer.
Dr. Rosenthal has conducted bench to bedside development of optical contrast agents to identify cancer in the operating room. He led a multidisciplinary team of scientists through successful IND application to allow testing of fluorescently labeled antibodies in the clinic and operating room. These early phase clinical trials have demonstrated that this technique can visualize microscopic cancer in the operating room and may significantly improve clinical outcomes.
Professor of Biomedical Data Science and of Radiology (Integrative Biomedical Imaging Informatics at Stanford), of Medicine (Biomedical Informatics Research) and, by courtesy, of Ophthalmology and of Computer Science
Current Research and Scholarly InterestsMy research interest is imaging informatics--ways computers can work with images to leverage their rich information content and to help physicians use images to guide personalized care. Work in our lab thus lies at the intersection of biomedical informatics and imaging science.
Professor of Radiology (Radiological Sciences Lab)
Current Research and Scholarly InterestsMy research interests center on MRI research, including high-field and high-resolution MRI technology development as well as applications of advanced MRI techniques to studying the brain, cardiovascular system and cancer.