Wu Tsai Neurosciences Institute
Showing 1-10 of 15 Results
Professor of Developmental Biology
Current Research and Scholarly InterestsWe use genetic and cellular approaches to investigate the molecular basis of glial development and myelination in the zebrafish.
Assistant Professor of Neurobiology
Current Research and Scholarly InterestsThe Tan Lab studies the single-cell 3D genome architectural basis of neurodevelopment and aging by developing the next generation of in vivo multi-omic assays and algorithms, and applying them to the human and mouse cerebellum.
Professor of Genetics and, by courtesy, of Statistics
Current Research and Scholarly InterestsDevelop statistical and computational methods for population genomics analyses; modeling human evolutionary history; genetic association studies in admixed populations.
Professor of Neurosurgery
BioDr. Peter Tass investigates and develops neuromodulation techniques for understanding and treating neurologic conditions such as Parkinson’s disease, epilepsy, dysfunction following stroke and tinnitus. He creates invasive and non-invasive therapeutic procedures by means of comprehensive computational neuroscience studies and advanced data analysis techniques. The computational neuroscience studies guide experiments that use clinical electrophysiology measures, such as high density EEG recordings and MRI imaging, and various outcome measures. He has pioneered a neuromodulation approach based on thorough computational modelling that employs dynamic self-organization, plasticity and other neuromodulation principles to produce sustained effects after stimulation. To investigate stimulation effects and disease-related brain activity, he focuses on the development of stimulation methods that cause a sustained neural desynchronization by an unlearning of abnormal synaptic interactions. He also performs and contributes to pre-clinical and clinical research in related areas.
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain)
Current Research and Scholarly InterestsMy overall research interest is to understand how the immune system interacts with the nervous system after injury to promote the transition from acute to chronic pain. In my clinical practice I care for patients with persistent pain that often occurs after minor trauma such as fracture or surgery. Using basic science approaches including whole system immune phenotyping with mass cytometry and genetic manipulation of peripheral and central immune cells, we seek to dissect the temporal and tissue-specific contribution of these cells to either promotion or inhibition of healing.
Associate Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly InterestsOver the past decade there has been tremendous advances in the field of Interventional Oncology with the clinical utilization of multiple new innovative locoregional therapies (i.e. chemoembolization, percutaneous ablation).
Looking forward, our ability to super-selectively deliver new therapies directly to target organs. These therapies include nanoparticles, stem cells and gene therapy and will open new pathways into the emerging field of Interventional Regenerative Medicine.
Assistant Professor of Neurosurgery
Current Research and Scholarly InterestsThe long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
Professor of Biology (Hopkins Marine Station)
Current Research and Scholarly InterestsNeurobiology, signal transduction
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly InterestsWe develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.