School of Engineering


Showing 1-50 of 151 Results

  • Daniel Herschlag

    Daniel Herschlag

    Professor of Biochemistry and, by courtesy, of Chemical Engineering and of Chemistry

    Current Research and Scholarly InterestsOur research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.

  • James Swartz

    James Swartz

    James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering

    BioUsing and Understanding Cell-Free Biology

    Swartz Lab General Research Focus:

    The current and projected research in the Swartz lab balances basic research in microbial metabolism, protein expression, and protein folding with a strong emphasis on compelling applications. The power and versatility of cell-free methods coupled with careful evaluation and engineering of these new systems enables a whole new range of applications and scientific investigation. Fundamental research on: the mechanisms and kinetics of ribosomal function, fundamental bioenergetics, basic mechanisms of protein folding, functional genomics, and metabolic pathway analysis is motivated by a variety of near- and medium term applications spanning medicine, energy, and environmental needs.

    Swartz Lab Application Focus:

    In the medical area , current research addresses the need for patient-specific vaccines to treat cancer. Particularly for lymphomas, there is a strong need to be able to make a new cancer vaccine for each patient. Current technologies are not practical for this demanding task, but cell-free approaches are rapid and inexpensive. We have already demonstrated feasibility in mouse tumor challenge studies and are now expanding the range of applications and working to improve the relevant technologies. Experience with these vaccines has also suggested a new and exciting format for making inexpensive and very potent vaccines for general use.

    To address pressing needs for a new and cleaner energy source, we are working towards an organism that can efficiently capture solar energy and convert it into hydrogen. The first task is to develop an oxygen tolerant hydrogenase using cell-free technology to express libraries of mutated enzymes that can be rapidly screened for improved function. Even though these are very complex enzymes, we have produced active hydrogenases with our cell-free methods. We are now perfecting the screening methods for rapid and accurate identification of improved enzymes. After these new enzymes are identified, the project will progress toward metabolic engineering and bioreactor design research to achieve the scales and economies required.

    To address environmental needs, we are developing an improved water filters using an amazing membrane protein, Aquaporin Z. It has the ability to reject all other chemicals and ions except water. We have efficiently expressed the protein into lipid bilayer vesicles and are now working to cast these membranes on porous supports to complete the development of a new and powerful water purification technology. The same lessons will be applied toward the development of a new class of biosensors that brings high sensitivity and selectivity.

  • Jennifer R. Cochran

    Jennifer R. Cochran

    Shriram Chair of Bioengineering, Associate Professor of Bioengineering and, by courtesy, of Chemical Engineering

    Current Research and Scholarly InterestsMolecular Bioengineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology

  • Stacey Bent

    Stacey Bent

    Jagdeep and Roshni Singh Professor in the School of Engineering, Senior Associate Dean for Faculty & Academic Affairs, Senior Fellow at Precourt and Professor, by courtesy, of Materials Science & Eng, of Electrical Eng and of Chemistry

    BioThe research in the Bent laboratory is focused on understanding and controlling surface and interfacial chemistry and applying this knowledge to a range of problems in semiconductor processing, micro- and nano-electronics, nanotechnology, and sustainable and renewable energy. Much of the research aims to develop a molecular-level understanding in these systems, and hence the group uses of a variety of molecular probes. Systems currently under study in the group include functionalization of semiconductor surfaces, mechanisms and control of atomic layer deposition, molecular layer deposition, nanoscale materials for light absorption, interface engineering in photovoltaics, catalyst and electrocatalyst deposition.

  • Curtis Frank

    Curtis Frank

    W. M. Keck, Sr. Professor in Engineering and Professor, by court, of Materials Science and Engineering and of Chemistry

    BioThe properties of ultrathin polymer films are often different from their bulk counterparts. We use spin casting, Langmuir-Blodgett deposition, and surface grafting to fabricate ultrathin films in the range of 100 to 1000 Angstroms thick. Macromolecular amphiphiles are examined at the air-water interface by surface pressure, Brewster angle microscopy, and interfacial shear measurements and on solid substrates by atomic force microscopy, FTIR, and ellipsometry. A vapor-deposition-polymerization process has been developed for covalent grafting of poly(amino acids) from solid substrates. FTIR measurements permit study of secondary structures (right and left-handed alpha helices, parallel and anti-parallel beta sheets) as a function of temperature and environment.

    A broadly interdisciplinary collaboration has been established with the Department of Ophthalmology in the Stanford School of Medicine. We have designed and synthesized a fully interpenetrating network of two different hydrogel materials that have properties consistent with application as a substitute for the human cornea: high water swellability up to 85%,tensile strength comparable to the cornea, high glucose permeability comparable to the cornea, and sufficient tear strength to permit suturing. We have developed a technique for surface modification with adhesion peptides that allows binding of collagen and subsequent growth of epithelial cells. Broad questions on the relationships among molecular structure, processing protocol, and biomedical device application are being pursued.

  • Gerald Fuller

    Gerald Fuller

    Fletcher Jones II Professor in the School of Engineering

    BioThe processing of complex liquids (polymers, suspensions, emulsions, biological fluids) alters their microstructure through orientation and deformation of their constitutive elements. In the case of polymeric liquids, it is of interest to obtain in situ measurements of segmental orientation and optical methods have proven to be an excellent means of acquiring this information. Research in our laboratory has resulted in a number of techniques in optical rheometry such as high-speed polarimetry (birefringence and dichroism) and various microscopy methods (fluorescence, phase contrast, and atomic force microscopy).

    Another application of orientation dynamics is in the development of solar cells. The efficiency of second-generation solar cells fabricated with conjugated polymers is limited by photoelectron transport within the polymer film. Inspired by electrorheological fluids, an external electric field is applied to the film to induce anisotropy in polymer crystallites, which is expected to enhance electron mobility.

    The microstructure of polymeric and other complex materials also cause them to have interesting physical properties and respond to different flow conditions in unusual manners. In our laboratory, we are equipped with instruments that are able to characterize these materials such as shear rheometer, capillary break up extensional rheometer, and 2D extensional rheometer. Then, the response of these materials to different flow conditions can be visualized and analyzed in detail using high speed imaging devices at up to 2,000 frames per second.

    There are numerous processes encountered in nature and industry where the deformation of fluid-fluid interfaces is of central importance. Examples from nature include deformation of the red blood cell in small capillaries, cell division and structure and composition of the tear film. Industrial applications include the processing of emulsions and foams, and the atomization of droplets in ink-jet printing. In our laboratory, fundamental research is in progress to understand the orientation and deformation of monolayers at the molecular level. These experiments employ state of the art optical methods such as polarization modulated dichroism, fluorescence microscopy, and Brewster angle microscopy to obtain in situ measurements of polymer films and small molecule amphiphile monolayers subject to flow. Langmuir troughs are used as the experimental platform so that the thermodynamic state of the monolayers can be systematically controlled. For the first time, well characterized, homogeneous surface flows have been developed, and real time measurements of molecular and microdomain orientation have been obtained. These microstructural experiments are complemented by measurements of the macroscopic, mechanical properties of the films.

  • Alfred M. Spormann

    Alfred M. Spormann

    Professor of Civil and Environmental Engineering, of Chemical Engineering and, by courtesy, of Biology

    Current Research and Scholarly InterestsMetabolism of anaerobic microbes in diseases, bioenergy, and bioremediation

  • Sarah Heilshorn

    Sarah Heilshorn

    Associate Professor of Materials Science and Engineering and, by courtesy, of Chemical Engineering and of Bioengineering

    Current Research and Scholarly InterestsProtein engineering
    Tissue engineering
    Regenerative medicine
    Biomaterials

  • Alexander Dunn

    Alexander Dunn

    Associate Professor of Chemical Engineering

    Current Research and Scholarly InterestsMy lab is deeply interested in understand how living cells sense and respond to mechanical stimuli.

  • Robert M. Waymouth

    Robert M. Waymouth

    Robert Eckles Swain Professor in Chemistry and, by courtesy, of Chemical Engineering

    BioRobert Eckles Swain Professor in Chemistry Robert Waymouth investigates new catalytic strategies to create useful new molecules, including sustainable polymers, synthetic fuels, and bioactive molecules. In one such breakthrough, Professor Waymouth and IBM researcher Jim Hedrick opened a new path for production of environmentally sustainable plastics and improved plastics recycling, earning recognition in the 2012 Presidential Green Chemistry Award.

    Born in 1960 in Warner Robins, Georgia, Robert Waymouth studied chemistry and mathematics at Washington and Lee University in Lexington, Virginia (B.S. and B.A., respectively, both summa cum laude, 1982). He developed an interest in synthetic and mechanistic organometallic chemistry during his doctoral studies in chemistry at the California Institute of Technology under Professor R.H. Grubbs (Ph.D., 1987). His postdoctoral research with Professor Piero Pino at the Institut fur Polymere, ETH Zurich, Switzerland, focused on catalytic hydrogenation with chiral metallocene catalysts. He joined the Stanford University faculty as assistant professor in 1988, becoming full professor in 1997 and in 2000 the Robert Eckles Swain Professor of Chemistry.

    Today, the Waymouth Group applies mechanistic principles to develop new concepts in catalysis, with particular focus on the development of organometallic and organic catalysts for the synthesis of complex macromolecular architectures. In organometallic catalysis, the group devised a highly selective alcohol oxidation catalyst that selectively oxidizes unprotected polyols and carbohydrates to alpha-hyroxyketones. The Waymouth group pioneered the development of catalysts that can access multiple kinetic states during a polymerization reaction in order to control sequence distribution. They devised a novel strategy for the synthesis of elastomeric polypropylene utilizing a metallocene catalyst whose structure was designed to interconvert between chiral and achiral coordination geometries on the timescale of the synthesis of a single polymer chain.

    In collaboration with Jim Hedrick of IBM laboratories, the Waymouth Group has developed an extensive platform of organic catalysts for the controlled ring-opening polymerization of lactones, carbonates and other heterocyclic monomers. Mechanistic studies of nucleophilic N-heterocyclic carbene catalysts revealed an unusual zwitterionic ring-opening polymerization method which enabled the synthesis of high molecular weight cyclic polymers, a novel topology for these biodegradable and biocompatible macromolecules. In collaboration with the Wender group, the Waymouth group has devised selective organocatalytic strategies for the synthesis of functional degradable polymers and oligomers that function as "molecular transporters" to deliver drugs and probes into cells. These efforts combine elements of mechanistic organic and organometallic chemistry, polymer synthesis, and homogeneous catalysis to rationally design new macromolecular structures.

  • Zhenan Bao

    Zhenan Bao

    K. K. Lee Professor in the School of Engineering and Professor, by courtesy, of Materials Science and Engineering and of Chemistry

    BioZhenan Bao joined Stanford University in 2004. She is currently a K.K. Lee Professor in Chemical Engineering, and with courtesy appointments in Chemistry and Material Science and Engineering. She is a member of the National Academy of Engineering and National Academy of Inventors. She founded the Stanford Wearable Electronics Initiative (eWEAR) and is the current faculty director. She is also an affiliated faculty member of Precourt Institute, Woods Institute, ChEM-H and Bio-X. Professor Bao received her Ph.D. degree in Chemistry from The University of Chicago in 1995 and joined the Materials Research Department of Bell Labs, Lucent Technologies. She became a Distinguished Member of Technical Staff in 2001. Professor Bao currently has more than 400 refereed publications and more than 60 US patents. She served as a member of Executive Board of Directors for the Materials Research Society and Executive Committee Member for the Polymer Materials Science and Engineering division of the American Chemical Society. She was an Associate Editor for the Royal Society of Chemistry journal Chemical Science, Polymer Reviews and Synthetic Metals. She serves on the international advisory board for Advanced Materials, Advanced Energy Materials, ACS Nano, Accounts of Chemical Reviews, Advanced Functional Materials, Chemistry of Materials, Chemical Communications, Journal of American Chemical Society, Nature Asian Materials, Materials Horizon and Materials Today. She is one of the Founders and currently sits on the Board of Directors of C3 Nano Co., a silicon valley venture funded company. She is Fellow of AAAS, ACS, MRS, SPIE, ACS POLY and ACS PMSE. She was a recipient of the L'Oreal UNESCO Women in Science Award in 2017. She was awarded the ACS Applied Polymer Science Award in 2017, ACS Creative Polymer Chemistry Award in 2013 ACS Cope Scholar Award in 2011, and was selected by Phoenix TV, China as 2010 Most influential Chinese in the World-Science and Technology Category. She is a recipient of the Royal Society of Chemistry Beilby Medal and Prize in 2009, IUPAC Creativity in Applied Polymer Science Prize in 2008, American Chemical Society Team Innovation Award 2001, R&D 100 Award, and R&D Magazine Editors Choice Best of the Best new technology for 2001. She has been selected in 2002 by the American Chemical Society Women Chemists Committee as one of the twelve Outstanding Young Woman Scientist who is expected to make a substantial impact in chemistry during this century. She is also selected by MIT Technology Review magazine in 2003 as one of the top 100 young innovators for this century. She has been selected as one of the recipients of Stanford Terman Fellow and has been appointed as the Robert Noyce Faculty Scholar, Finmeccanica Faculty Scholar and David Filo and Jerry Yang Faculty Scholar.

  • Chaitan Khosla

    Chaitan Khosla

    Wells H. Rauser and Harold M. Petiprin Professor in the School of Engineering and Professor of Chemistry and, by courtesy, of Biochemistry

    Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.

    For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.

    For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine.

    Recently, we initiated a collaborative program involving multiple Stanford laboratories (http://med.stanford.edu/virx.html.html) that is aimed at developing a fundamentally new approach to treating viral infections. As part of this initiative, we are developing an antiviral chemotherapy that modulates pyrimidine metabolism in the host, and also a platform to engineer immuno-modulatory glycolipids for the treatment of influenza.

  • Christina Smolke

    Christina Smolke

    Professor of Bioengineering and, by courtesy, of Chemical Engineering

    BioProfessor Smolke's research program focuses on developing modular genetic platforms for programming information processing and control functions in living systems, resulting in transformative technologies for engineering, manipulating, and probing biological systems. She has pioneered the design and application of a broad class of RNA molecules, called RNA devices, that process and transmit user-specified input signals to targeted protein outputs, thereby linking molecular computation to gene expression. This technology has been extended to efficiently construct multi-input devices exhibiting various higher-order information processing functions, demonstrating combinatorial assembly of many information processing, transduction, and control devices from a smaller number of components. Her laboratory is applying these technologies to addressing key challenges in cellular therapeutics, targeted molecular therapies, and green biosynthesis strategies.

  • Thomas Jaramillo

    Thomas Jaramillo

    Associate Professor of Chemical Engineering and of Photon Science

    BioRecent years have seen unprecedented motivation for the emergence of new energy technologies. Global dependence on fossil fuels, however, will persist until alternate technologies can compete economically. We must develop means to produce energy (or energy carriers) from renewable sources and then convert them to work as efficiently and cleanly as possible. Catalysis is energy conversion, and the Jaramillo laboratory focuses on fundamental catalytic processes occurring on solid-state surfaces in both the production and consumption of energy. Chemical-to-electrical and electrical-to-chemical energy conversion are at the core of the research. Nanoparticles, metals, alloys, sulfides, nitrides, carbides, phosphides, oxides, and biomimetic organo-metallic complexes comprise the toolkit of materials that can help change the energy landscape. Tailoring catalyst surfaces to fit the chemistry is our primary challenge.

  • Eric Shaqfeh

    Eric Shaqfeh

    Lester Levi Carter Professor of Chemical Engineering and Professor of Mechanical Engineering

    Current Research and Scholarly InterestsI have over 25 years experience in theoretical and computational research related to complex fluids following my PhD in 1986. This includes work in suspension mechanics of rigid partlcles (rods), solution mechanics of polymers and most recently suspensions of vesicles, capsules and mixtures of these with rigid particles. My research group is internationally known for pioneering work in all these areas.

  • Andrew Spakowitz

    Andrew Spakowitz

    Associate Professor of Chemical Engineering and of Materials Science and Engineering

    Current Research and Scholarly InterestsTheory and computation of biological processes and complex materials

  • Elizabeth Sattely

    Elizabeth Sattely

    Assistant Professor of Chemical Engineering

    BioPlants have an extraordinary capacity to harvest atmospheric CO2 and sunlight for the production of energy-rich biopolymers, clinically used drugs, and other biologically active small molecules. The metabolic pathways that produce these compounds are key to developing sustainable biofuel feedstocks, protecting crops from pathogens, and discovering new natural-product based therapeutics for human disease. These applications motivate us to find new ways to elucidate and engineer plant metabolism. We use a multidisciplinary approach combining chemistry, enzymology, genetics, and metabolomics to tackle problems that include new methods for delignification of lignocellulosic biomass and the engineering of plant antibiotic biosynthesis.

  • Jeffrey B. Tok

    Jeffrey B. Tok

    Laboratory Director, Chemical Engineering

    BioEducation:

    The University of Washington, Seattle, WA, B.Sc. (Chemistry & Biochemistry), 1989-1992
    The University of Chicago, Chicago, IL, Ph.D. (Bioorganic Chemistry), 1992-1996
    Harvard University, Boston, MA, Postdoctoral Research Fellow (Biochemistry and Bioorganic Chemistry), 1997-1999


    Work Experience:

    Assistant Professor, City University of New York, York College and Graduate Center, 1999-2003
    Associate Professor, City University of New York, York College and Graduate Center, 2003-2004
    Principal Scientist, Lawrence Livermore National Laboratory, 2004-2008
    Chief BioScientist, Micropoint Bioscience Inc, 2008-2010
    Senior Research Engineer/Scientist, Stanford University, 2010-present
    Director, Uytengsu Teaching Center, Shriram Center, 2015-present
    Manager, Soft & Hybrid Materials Shared Facility, Stanford Nano Shared Facility, 2010-present
    Manager & Instructor, Dept of Chemical Engineering Teaching Lab, 2010-present

  • Julie A. Fogarty

    Julie A. Fogarty

    Ph.D. Student in Chemical Engineering, admitted Autumn 2013

    BioJulie is currently at Stanford University pursuing her Ph.D. in Chemical Engineering where she works for Prof. James R. Swartz on developing a modular virus-like particle based vaccine platform. Her current focus is on developing novel vaccines for HIV and Zika. She is also pursuing work related to further development of a potentially broadly protective flu antigen, as well as work to design a scalable process for manufacturing this antigen. Julie has a B.S. in Chemical Engineering from the University of Texas at Austin and is excited by the biological applications of chemical engineering.

    Julie spent two years working for Dr. Jennifer A. Maynard at the University of Texas at Austin in the Chemical Engineering Department. Her project focused on phage display using coat protein p8 variants as a means for engineering low affinity protein-protein interactions. This work could provide a platform for engineering T-cell receptors (a largely under-exploited immune molecule) to create better therapeutics for a number of different diseases.

    She has past research experience working with miRNA at the University of Texas M.D. Anderson Cancer Center in the Department of Experimental Therapeutics under the supervision of Dr. George A. Calin. She also has experience working with pH responsive hydrogels at the University of Texas at Austin in the Chemical Engineering Department under the supervision of Dr. Nicholas A. Peppas. Finally, Julie interned with Merck in their Manufacturing Division for two summers and was a Merck Engineering and Technology Fellow.

    She was formerly the President of the Stanford Chemical Engineering Graduate Action Committee and has served on many of their student committees.

    As an undergraduate, she served as the Vice President External for the UT Chapter of AIChE for two years and the Service Chair of the organization for one year. In addition, Julie served as President, Vice President, and Service Chair for the Epsilon Chapter of Omega Chi Epsilon.

  • Matteo Cargnello

    Matteo Cargnello

    Assistant Professor of Chemical Engineering

    BioMatteo Cargnello is Assistant Professor of Chemical Engineering and Terman Faculty Fellow. His group research interests are in the preparation and use of uniform and tailored materials for heterogeneous catalysis and photocatalysis and the technological exploitation of nanoparticles and nanocrystals. Reactions of interest are related to sustainable energy generation and use, control of emissions of greenhouse gases, and better utilization of abundant building blocks (methane, biomass). Dr. Cargnello received his Ph.D. in Nanotechnology in 2012 at the University of Trieste (Italy) and he was then a post-doctoral scholar in the Chemistry Department at the University of Pennsylvania (Philadelphia) before joining the Faculty at Stanford. He is the recipient of the ENI Award Debut in Research 2013 and the European Federation of Catalysis Societies Award as best European Ph.D. thesis in catalysis in 2013.

  • Joshua McEnaney

    Joshua McEnaney

    Postdoctoral Research Fellow, Chemical Engineering

    BioJosh is a postdoctoral scholar in the Jaramillo chemical engineering group working on electrochemical nitrogen reduction.

  • H. Tom Soh

    H. Tom Soh

    Professor of Radiology (Early Detection), of Electrical Engineering and, by courtesy, of Chemical Engineering

    BioDr. Soh received his B.S. with a double major in Mechanical Engineering and Materials Science with Distinction from Cornell University and his Ph.D. in Electrical Engineering from Stanford University. From 1999 to 2003, Dr. Soh served as the technical manager of MEMS Device Research Group at Bell Laboratories and Agere Systems. He was a faculty member at UCSB before joining Stanford in 2015. His current research interests are in analytical biotechnology, especially in high-throughput screening, directed evolution, and integrated biosensors.