School of Humanities and Sciences
Showing 1,281-1,300 of 5,804 Results
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Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioResearch and Scholarship
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
In a second program area, the Du Bois group is exploring voltage-gated ion channel structure and function using the tools of chemistry in combination with those of molecular biology, electrophysiology, microscopy and mass spectrometry. Much of this work has focused on studies of eukaryotic Na and Cl ion channels. The Du Bois lab is interested in understanding the biochemical mechanisms that underlie channel subtype regulation and how such processes may be altered following nerve injury. Small molecule toxins serve as lead compounds for the design of isoform-selective channel modulators, affinity reagents, and fluorescence imaging probes. Access to toxins and modified forms thereof (including saxitoxin, gonyautoxin, batrachotoxin, and veratridine) through de novo synthesis drives studies to elucidate toxin-receptor interactions and to develop new pharmacologic tools to study ion channel function in primary cells and murine pain models. -
John Duchi
Associate Professor of Statistics, of Electrical Engineering and, by courtesy, of Computer Science
Current Research and Scholarly InterestsMy work spans statistical learning, optimization, information theory, and computation, with a few driving goals: 1. To discover statistical learning procedures that optimally trade between real-world resources while maintaining statistical efficiency. 2. To build efficient large-scale optimization methods that move beyond bespoke solutions to methods that robustly work. 3. To develop tools to assess and guarantee the validity of---and confidence we should have in---machine-learned systems.
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Mark Duggan
Wayne and Jodi Cooperman Professor and Senior Fellow at the Stanford Institute for Economic Policy Research
BioMark Duggan is a Professor of Economics at Stanford University and a Research Associate at the National Bureau of Economic Research. He received his B.S. and M.S. degrees in Electrical Engineering at M.I.T. in 1992 and 1994, respectively, and his Ph.D. in Economics from Harvard University in 1999. He currently is a Co-Editor at the American Economic Journal: Economic Policy and was previously a Co-Editor at the Journal of Public Economics. Before arriving to Stanford in the summer of 2014, Duggan served on the faculty at the University of Pennsylvania's Wharton School (2011-14), the University of Maryland's Economics Department (2003-11), and the University of Chicago's Economics Department (1999-2003).
Professor Duggan's research focuses primarily on the effect of government expenditure programs such as Social Security, Medicare, and Medicaid on the behavior of individuals and firms. Some of his more recent research is exploring the effect of federal disability programs on the labor market and of changes to the Medicare and Medicaid programs on the cost and quality of health care. He is also estimating the effect of patent reforms in India on the price and utilization of pharmaceutical treatments. His research has been published in leading academic journals including the American Economic Review, the Journal of Political Economy, and the Quarterly Journal of Economics and has been featured in outlets such as The Economist, the New York Times, and the Wall Street Journal.
Professor Duggan was the 2010 recipient of the ASHEcon Medal, which is awarded every two years by the American Society of Health Economists to the economist aged 40 and under in the U.S. who has made the most significant contributions to the field of health economics. Along with his co-author Fiona Scott Morton, he received the National Institute for Health Care Management's 2011 Health Care Research Award for their work on Medicare Part D. He was a Fellow of the Alfred P. Sloan Foundation from 2004 to 2006 and a Visiting Fellow at the Brookings Institution from 2006 to 2007. His research has been funded by the National Science Foundation, the National Institutes of Health, the Social Security Administration, and the Robert Wood Johnson Foundation. Duggan served from 2009 to 2010 as the Senior Economist for Health Care Policy at the White House Council of Economic Advisers and has also been an Expert Witness for the U.S. Department of Justice. -
Rob Dunbar
W.M. Keck Professor in the School of Earth Sciences, Professor of Oceans, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Earth System Science
Current Research and Scholarly InterestsOcean processes, biogeochemistry, climatology/paleoclimatology, isotopic chemistry, ocean policy
