Institute for Stem Cell Biology and Regenerative Medicine
Showing 121-130 of 153 Results
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Judith Shizuru
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Current Research and Scholarly InterestsTransplantation of defined populations of allogeneic hematopoietic cells. Specifically, the way in which hematopoietic cell grafts alter antigen specific immune responses to allo-, auto- and viral antigens. The cellular and molecular basis of resistance to engraftment of allogeneic hematopoietic stem cells.
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Thomas Sudhof
Avram Goldstein Professor in the School of Medicine, Professor of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
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Sivakamasundari V
Instructor, Institute for Stem Cell Biology and Regenerative Medicine
BioMy research interests are focused on understanding the molecular basis of early development and stem cells, as it is often aberrations in stem cells or signaling mechanisms between tissues that lead to diseased states, including tumor development and cancer progression. Knowledge of stem cells and development is also critical to develop appropriate cell-based therapies for various diseases or injuries. My prior and current works take advantage of both traditional techniques (gene targeting, lineage tracing) and state-of-the-art technologies (Single cell RNA sequencing, Chromatin Immunoprecipitation (ChIP-seq), Imaging Mass Cytometry) to elucidate fundamental molecular mechanisms underlying signaling in tissue biology.
