Institute for Stem Cell Biology and Regenerative Medicine
Showing 21-40 of 147 Results
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Michael F. Clarke, M.D.
Karel H. and Avice N. Beekhuis Professor of Cancer Biology
Current Research and Scholarly InterestsDr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and diseases such as cancer and hereditary diseases; and ii) the identification and characterization of cancer stem cells. His laboratory is investigating how perturbations of stem cell regulatory machinery contributes to human disease. In particular, the laboratory is investigating epigenetic regulators of self renewal, the process by which stem cells regenerate themselves.
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Agnieszka Czechowicz, MD, PhD
Assistant Professor of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly InterestsDr. Czechowicz’s research is aimed at understanding how hematopoietic stem cells interact with their microenvironment in order to subsequently modulate these interactions to improve bone marrow transplantation and unlock biological secrets that further enable regenerative medicine broadly. This work can be applied across a variety of disease states ranging from rare genetic diseases, autoimmune diseases, solid organ transplantation, microbiome-augmentation and cancer.
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Tushar Desai
Professor of Medicine (Pulmonary, Allergy and Critical Care Medicine)
Current Research and Scholarly InterestsBasic and translational research in lung stem cell biology, cancer, pulmonary fibrosis, COPD, and acute lung injury/ARDS. Upper airway stem cell CRISPR gene correction followed by autologous stem cell transplantation to treat Cystic fibrosis. Using lung organoids and precision cut lung slice cultures of mouse and human lungs to study molecular regulation of lung stem cells. Using transgenic mice to visualize Wnt protein transmission from niche cell to stem cell in vivo.
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Maximilian Diehn, MD, PhD
Jack, Lulu, and Sam Willson Professor and Professor of Radiation Oncology (Radiation Therapy)
Current Research and Scholarly InterestsMy laboratory focuses on two main areas: 1) cancer stem cell biology and 2) novel biomarkers for identifying the presence of malignant cells (diagnostic), predicting outcome (prognostic), and predicting response to therapy (predictive). Areas of study include cancers of the lung, breast, and gastrointestinal system. Clinically I specialize in the treatment of lung cancer and applications of stereotactic ablative radiotherapy and perform both prospective and retrospective clinical studies.
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Asiri Ediriwickrema MD, PhD
Assistant Professor of Medicine (Hematology)
Current Research and Scholarly InterestsWe study hematopoiesis which is the complex process of producing blood cells that are essential for maintaining our basic health and well being. Our mission is to learn how these individual cells change as people age and develop cancer. Blood cell production is driven by the hematopoietic stem cell which gives rise to an incredible diversity of cells throughout life. Our research focuses on how dysregulation of this process leads to cytopenias and hematologic malignancies. We have expertise that spans clinical medicine, functional hematology, molecular and cellular biology, genomics, bioinformatics, and machine learning. By integrating advanced experimental and computational methods, we are examining blood cell development and function at single-cell resolution to advance patient diagnostics and treatment.
