Institute for Stem Cell Biology and Regenerative Medicine
Showing 41-50 of 151 Results
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Asiri Ediriwickrema MD, PhD
Assistant Professor of Medicine (Hematology)
BioAsiri Ediriwickrema, MD, PhD, is a physician-scientist who leads a systems hematology laboratory at Stanford and directs a clinical practice focused on myelodysplastic neoplasms and clonal hematopoiesis. Our research group studies hematopoiesis—the complex process by which hematopoietic stem cells generate the diverse blood cells essential for health throughout life. Our mission is to understand how individual blood cells change during aging and cancer development, with particular focus on how dysregulation of this process leads to cytopenias and hematologic malignancies.
We integrate expertise spanning clinical medicine, functional hematology, molecular and cellular biology, genomics, bioinformatics, and machine learning. By combining advanced experimental techniques with computational approaches, we examine blood cell development and function at single-cell resolution. Our work aims to identify the earliest cellular changes in cancer development, map how stem cells interact within their tissue environments, and develop AI-powered tools that predict stem cell behavior and disease progression. Our goal is to translate these efforts into improved diagnostics and precision therapeutic strategies for patients with blood disorders and malignancies.
Dr. Ediriwickrema earned his undergraduate degree in Engineering from the Massachusetts Institute of Technology, his MD (Cum Laude) from Yale University, and his PhD from Stanford University. He completed his residency in Internal Medicine and fellowship in Hematology at Stanford, where he also conducted his doctoral and postdoctoral research in the laboratory of Dr. Ravi Majeti. His research identified novel populations of multipotent progenitor cells in normal hematopoiesis and leukemia stem cells in acute myeloid leukemia (AML). -
Heather Gentner
Director of Finance and Administration (SoM), Stem Cell Bio Regenerative Med Institute
Current Role at StanfordI am the Director of Finance and Administration for the Institute for Stem Cell Biology and Regenerative Medicine (ISCBRM) in the School of Medicine. I oversee and carry out administrative and financial related functions for the department.
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Natalia Gomez-Ospina
Assistant Professor of Pediatrics (Genetics)
Current Research and Scholarly InterestsDr. Gomez-Ospina is a physician scientist and medical geneticist with a strong interest in the diagnosis and management of genetic diseases.
1) Lysosomal storage diseases:
Her research program is on developing better therapies for a large class of neurodegenerative diseases in children known as lysosomal storage disorders. Her current focus is on developing genome editing of hematopoietic stem cells as a therapeutic approach for these diseases beginning with Mucopolysaccharidosis type 1 and Gaucher disease. She established a genetic approach where therapeutic proteins can be targeted to a single well-characterized place in the genome known as a safe harbor. This approach constitutes a flexible, “one size fits all” approach that is independent of specific genes and mutations. This strategy, in which the hematopoietic system is commandeered to express and deliver therapeutic proteins to the brain can potentially change the current approaches to treating childhood neurodegenerative diseases and pave the way for alternative therapies for adult neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease
2) Point of care ammonia testing
She also works in collaboration with other researchers at Stanford to develop point-of-care testing for serum ammonia levels. Such device will greatly improve the quality of life of children and families with metabolic disorders with hyperammonemia.
3) Gene discovery
Dr Gomez-Ospina lead a multi-institutional collaboration resulting in the discovery of a novel genetic cause of neonatal and infantile cholestatic liver disease. She collaborated in the description of two novel neurologic syndromes caused by mutations in DYRK1 and CHD4.
For more information go to our website:
https://www.gomezospina.com/
