Maternal & Child Health Research Institute (MCHRI)
Showing 481-500 of 1,008 Results
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Anshul Kundaje
Associate Professor of Genetics and of Computer Science
Current Research and Scholarly InterestsWe develop statistical and machine learning frameworks to model gene regulation and decipher the genetic and molecular basis of disease
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Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
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Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu). -
Clete A. Kushida, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsDr. Kushida is a neurologist and sleep specialist who directs several NIH- and industry-sponsored research studies, focused on topics such as the physical features and neurocognitive changes associated with the obstructive sleep apnea syndrome, the epidemiology and treatment of restless legs syndrome/periodic limb movement disorder, primary care sleep education and training, and countermeasures for sleep loss.
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Angelle Desiree LaBeaud
Professor of Pediatrics (Infectious Diseases), Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Epidemiology and Population Health and of Environmental Social Sciences
Current Research and Scholarly InterestsArthropod-borne viruses are emerging and re-emerging infections that are spreading throughout the world. Our laboratory investigates the epidemiology of arboviral infections, focusing on the burden of disease and the long-term complications on human health. In particular, Dr. LaBeaud investigates dengue, chikungunya, and Rift Valley fever viruses in Kenya, where outbreaks cause fever, arthritis, retinitis, encephalitis, and hemorrhagic fever. Our main research questions focus on the risk factors for arboviral infections, the development of diagnostic tests that can be administered in the field to quickly determine what kind of arboviral infection a person has, and the genetic and immunologic investigation of why different people respond differently to the same infection. Our long-term goals are to contribute to a deeper understanding of arboviral infections and their long-term health consequences and to optimize control strategies to prevent these emerging infections. Our laboratory also investigates the effects of antenatal and postnatal parasitic infections on vaccine responses, growth, and development of Kenyan children.
My lab at Stanford supports the field work that is ongoing in Kenya, but we also have several projects that are based locally. We strive to improve diagnostics of arboviral infections and are using Luminex technology to build a new screening assay. We also have created a Luminex based platform to assess vaccine responses against multiple pathogens. -
Norman J. Lacayo, MD
Associate Professor of Pediatrics (Hematology and Oncology)
Current Research and Scholarly InterestsPediatric Hematology/Oncology, Phase I drug studies for refractory and relapsed leukemia; genomic studies, biologic risk-stratification and treatment of acute myeloid leukemia; prediction or induction response and risk of relapse using phosphoproteomics in childhood AML; novel MRD techniques in childhood ALL.
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Amy Ladd, MD
Elsbach-Richards Professor of Surgery, Emerita
Current Research and Scholarly InterestsResearch Interests
1. The kinematics and forces associated with thumb carpometcarpal (CMC) function and pathology
2. The anatomy, microstructure, and immunofluorescent characteristics of the thumb CMC joint
3. Pathomechaniics of CMC arthritis: biomechanical wear, injury, genetic, and environmental causes
4. Biomechanics of the golf swing
5. Archiving, vitalizing, and innovating medical and surgical knowledge, most recently with innovative iBook monographs -
Teresa LaFromboise
Professor of Education
Current Research and Scholarly InterestsBicultural competence and resilience in ethnic minority adolescent development. Particularly, the influence of enculturation and acculturation experiences on adolescent development. Cultural considerations in individual, school and community-based psychological interventions with adolescents and emerging adults.
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David D. Laitin
James T. Watkins IV and Elise V. Watkins Professor
BioDavid D. Laitin is the James T. Watkins IV and Elise V. Watkins Professor of Political Science at Stanford University. He received his BA from Swarthmore College, and then served as a Peace Corps Volunteer in Somalia and Grenada, where he became national tennis champion in 1970. Back in the US, he received his Ph.D. in political science from UC Berkeley, working under the direction of Ernst Haas and Hanna Pitkin.
He has taught at three great universities: UCSD (1975-87), the University of Chicago (1987-1999) and now at Stanford. Over his career, as a student of comparative politics, he has conducted field research in Somalia, Yorubaland (Nigeria), Catalonia (Spain), Estonia, and France, all the time focusing on issues of language and religion, and how these cultural phenomena link nation to state. His books include Politics, Language and Thought: The Somali Experience (1977), Hegemony and Culture: Politics and Religious Change among the Yoruba (1986), Language Repertoires and State Construction in Africa (1992), Identity in Formation: The Russian-Speaking Populations in the Near Abroad (1998); Nations, States and Violence (2007); Why Muslim Integration Fails in Christian-Heritage Societies (2016); and African Politics Since Independence (2019).
In collaboration with James Fearon, he has published several papers on ethnicity, ethnic cooperation, the sources of civil war, and on policies that work to settle civil wars. Laitin has also collaborated with Alan Krueger on international terrorism and with Eli Berman on suicide terrorism.
In 2008-2009, with support from the National Science Foundation, and with a visiting appointment at Sciences-Po Paris, Laitin conducted ethnographic, survey and experimental research on Muslim integration into France, seeking to assess the magnitude of religious discrimination and isolate the mechanisms that sustain it. In collaboration with Claire Adida and Marie-Anne Valfort, they published the results in Why Muslim Integration Fails in Christian Heritage Societies (Harvard Press, 2016).
In 2016, Laitin became co-director of Stanford's Immigration Policy Lab, and has co-authored several papers published in "Science", "Proceedings of the National Academy of Sciences" and "Nature Human Behavior" that estimate the effects of policy on immigrant integration.
Laitin has been a recipient of fellowships from the Howard Foundation, the Rockefeller Foundation, the Guggenheim Foundation, and the Russell Sage Foundation. He is an elected member of the American Academy of Arts and Sciences and the National Academy of Sciences. In 2021 Laitin was the recipient of the John Skytte Prize in Political Science from the Johan Skytte Foundation in Uppsala University, Sweden. -
Alfred Lane
Professor of Dermatology and of Pediatrics at the Stanford University Medical Center, Emeritus
Current Research and Scholarly InterestsDeveloping gene therapy for genetic skin diseases is my major focus. Prior to that, we are developing methods to give effective and efficient care to infants with rare and disabling genetic skin diseases including epidermolysis bullosa and ichthyosis as well as infants and children with unusual and difficult to manage vascular malformations. I am also interested in clinical studies within the NICU protecting premature infants skin and clinical studies in children with common skin diseases.
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Ruth Lathi, M.D.
Professor of Obstetrics and Gynecology (Reproductive Endocrinology and Infertility)
Current Research and Scholarly InterestsRecurrent miscarriage, genetic and other causes of miscarriage, preimplantation genetic diagnosis, effects of fertility treatments on androgen levels in early pregnancy and how fertility diagnosis and treatments affect pregnancy outcomes.
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Laura C. Lazzeroni, Ph.D.
Professor (Research) of Psychiatry and Behavioral Sciences, Emerita
BioA key signatory of the Great Barrington Declaration against the Covid lockdowns,before publication on October 5, 2020.
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Bomi Lee
Assistant Professor of Pediatrics (Gastroenterology, Hepatology, and Nutrition)
Current Research and Scholarly InterestsMy lab is dedicated to unraveling the complexities of the immune microenvironment and its role in the pathogenesis of pancreatic diseases, such as pancreatitis and pancreatic cancer. By leveraging cutting-edge technology, innovative experimental and genetic animal models, as well as human specimens from donors, we aim to identify novel immune markers and potential therapeutic targets. Our goal is to advance the understanding of immune cells and their contributions to these diseases and to transl
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Grace Lee
Professor of Pediatrics (Infectious Diseases)
BioDr. Grace Lee is Chief Quality Officer and the Christopher G. Dawes Endowed Director of Quality at Stanford Medicine Children’s Health and Lucile Packard Children’s Hospital Stanford, and Associate Dean for Maternal and Child Health (Quality and Safety) and Professor of Pediatrics at Stanford University School of Medicine. She oversees the Center for Pediatric and Maternal Value that seeks to improve quality, safety, patient experience and health equity across the organization. Dr. Lee previously served as a member of the Institute of Medicine Committee (IOM) to Review Priorities in the National Vaccine Plan, the IOM Committee on the Ethical and Scientific Issues in Studying the Safety of Approved Drugs, the National Academies of Sciences, Engineering, and Medicine (NASEM) Committee on Vaccine Research and Development Recommendations for Advancing Pandemic and Seasonal Influenza Preparedness and Response, and AHRQ's Healthcare Safety and Quality Improvement Research Study Section. She also served as a Board Member for the Society for Healthcare Epidemiology of America (SHEA), Pediatric Infectious Diseases Society (PIDS), and the National Academy of Medicine (NAM) Board on Population Health and Public Health Practice. She was previously the Chair of the U.S. Advisory Committee on Immunization Practices (ACIP) that recommends vaccines for the U.S. population, and she is an elected member of the National Academy of Medicine.
