School of Medicine
Showing 1,071-1,080 of 1,299 Results
-
Lawrence Steinman, MD
George A. Zimmermann Professor and Professor of Pediatrics
Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
-
Lars Steinmetz
Dieter Schwarz Foundation Endowed Professor and Professor of Genetics
Current Research and Scholarly InterestsWe apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.
-
Laurel Stell
Research Engineer, Biomedical Data Science
Current Role at StanfordInvestigating non-glycemic genetic effects on HbA1c using the Veterans Administration Million Veteran Program (MVP). HbA1c is a widely used test that reflects average blood sugar level for the past two to three months. It is well known that certain genetic blood conditions, such as sickle cell disease, can cause HbA1c to be a misleading indicator of blood glucose levels. I am investigating the extent to which genetic variants can have this effect even without a diagnosis of one of these conditions. I am also investigating whether these effects are impacting clinical diagnosis and treatment of diabetes, and whether such impacts are reflected in health outcomes.
The impact of these variants has potentially been overlooked because they are very rare in populations with European genetic ancestry. As with the variant for sickle cell disease, they only persist when they provide an evolutionary advantage, such as protecting against malaria infection and its symptoms. Consequently, the genetic variants that I am analyzing do not appear in most genetic biobanks frequently enough to enable my analyses. MVP, however, includes genetic data for over 100,000 Veterans with African genetic ancestry, making it an ideal resource for this research. Since these variants are common among individuals with African genetic ancestry but practically non-existent in European genetic ancestry, this research may provide insight into racial health disparities in the US, particularly in T2D prevalence and outcomes.
I've also been a member of the department's JEDI Committee since its inception in 2021, providing assistance wherever I can. -
Kathryn Stephens
Affiliate, Dean's Office Operations - Dean Other
Resident in Psychiatry and Behavioral SciencesBioKathryn C. Stephens, MD, is currently a resident in the Department of Psychiatry and Behavioral Sciences. She completed a BA in anthropology at Harvard University, an MD at the University of Arkansas for Medical Sciences, and an internship year in Obstetrics & Gynecology residency at the Texas Tech Health Science Center in El Paso.
During her time at Harvard, she conducted research with the Institute for Healthcare Improvement (IHI in Boston) on the role of mobile clinics’ in providing primary care and preventative screenings to medically underserved areas. She continued her interest in providing care in resource-limited settings after college as she worked for one year in a women’s crisis center in Bangalore, India. During medical school, she held leadership roles in the Global Health Interest Group and continued her work in free clinics both locally and abroad in Panama, Honduras, and Guatemala. She conducted research on obstetric emergencies such as placenta accreta, which informed her understanding of birth trauma and its impact on women’s mental health. During her time in Ob/Gyn residency, she was awarded for the top score on the annual knowledge exam in her program as a first-year resident. Prior to beginning her training at Stanford, she had the privilege of contributing to several projects in the in the Department of Psychiatry and Behavioral Sciences' Race and Mental Health Lab as the lab's Research Coordinator. One such project included writing a curriculum for active bystander intervention of workplace discrimination (i.e. "Upstander Bias Training"), which has been taught to several departments within the Stanford School of Medicine.
Her areas of clinical and research interest include women’s reproductive psychiatry, the intersection of race, culture and mental health, integrative approaches to wellness and community psychiatry.
