School of Medicine
Showing 1,061-1,070 of 1,546 Results
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Trung Hoang Minh Pham
Assistant Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsUncovering mechanisms of tissue immunity and immunophysiology during persistent infection
The immune system safeguards the health of complex organisms by rapidly eliminating invading pathogens, curbing infection-induced tissue disruptions, and maintaining tissue homeostasis. Many bacterial pathogens evade host antimicrobial mechanisms and persist in infected tissues at low levels for long periods of time even in the presence of innate and adaptive immune resistance. During persistent infection, the immune system simultaneously orchestrates antimicrobial responses to contain the pathogen, repairs damaged tissue, regulates nutrient resources, and maintains other tissue physiological functions to ensure host survival. Failure of any of these tasks leads to uncontrolled infection, devastating disease, and even death. The goals of our research are to understand:
1)What are the innate and adaptive immune cellular mechanisms that contain pathogens during persistent infection?
2)How are tissue physiological functions, such as tissue repair and nutrient regulation, maintained during persistent infection?
3)How do pathogens survive innate and adaptive antimicrobial mechanisms in infected tissues?
4)How does persistent infection impact host immunity to secondary infections of a similar or different pathogen?
Through investigating these fundamental questions, we may be able to decode the underlying cellular and molecular mechanisms that can be harnessed to eradicate infections, promote tissue resilience, and restore health after an infectious insult. We integrate immunology, tissue biology, microbiology, and genetics to uncover the mechanisms of tissue immunity and immunophysiology during persistent infection from the molecular to organismal level.
Current areas of research:
•Development, maintenance, and plasticity of macrophage functional diversity in infected tissue
•Tissue repair and nutrient regulation during persistent infection
•Cellular dynamics and bacterial persistence in lymphoid organs -
Lisa Pineda
Senior Simulations Specialist, Pediatrics - Neonatology
BioLisa received a Bachelor of Science in Kinesiology with an emphasis in Athletic Training from San Jose State University, a Master of Science in Perinatal Clinical Nurse Specialist/Neonatal Emphasis from the University of California San Francisco, and a Post-Graduate Family Nurse Practitioner Certificate from San Francisco State University.
Lisa started her nursing career at Lucile Packard Children’s Hospital in the Labor and Delivery Unit. It became clear early in her career that research-driven high-quality patient-centered care was integral to her learning and passion for nursing. As a staff nurse, she participated in multiple obstetric simulations at CAPE, and she was immediately drawn to the systematic approach, clear communication, and debriefing process within the simulation methodology. For more than two decades, Lisa’s work has included bedside nursing, advanced practice nursing for women and children, and public health nursing with a particular passion for research dedicated to improving patient outcomes. -
Benjamin Pinsky
Professor of Pathology, of Medicine (Infectious Diseases) and, by courtesy, of Pediatrics (Infectious Diseases)
Current Research and Scholarly InterestsDevelopment and application of molecular assays for the diagnosis and management of infectious diseases.
