School of Medicine
Showing 291-300 of 1,552 Results
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Pasqualina Colella
Affiliate, Pediatrics - Genetics
BioDr. Pasqualina Colella is a scientist with expertise in gene and cell therapy for inherited diseases. She is currently a Senior Research Scientist at Stanford University, where she leads translational research on hematopoietic stem cell transplantation (HSCT), microglia replacement, myeloid cell recruitment to the central nervous system, and genome editing. Her goal is to improve treatment outcomes for neurodegenerative lysosomal storage diseases.
Dr. Colella earned her PhD at TIGEM (Italy), where she developed gene therapies for inherited retinal disorders, including dual AAV approaches for large gene delivery targeting Usher syndrome type 1B and Stargardt disease. During her postdoctoral studies at Genethon (France), she advanced AAV-based gene therapy for Pompe disease, improving efficacy through transgene and promoter engineering. Her work has contributed to several ongoing clinical trials, including those for USH1B and Pompe disease.
Her research has led to more than 30 peer-reviewed publications (16 as first author, 7 as co-corresponding) and 6 patents. She has received awards including the Marie Skłodowska-Curie Fellowship, the Innovative Research Grant from the National MPS Society, and Stanford School of Medicine Shoshana Levy Award to Support Women in Science (Career Development Award). She was also a finalist for the ERC Starting Grant in 2019. -
Ruben J Colman, MD, PhD
Assistant Professor of Pediatrics (Gastroenterology)
BioDr. Colman is a pediatric gastroenterologist and physician-scientist with an overarching goal to improve and optimize the quality of care and outcomes for children with inflammatory bowel diseases (IBD) through precision medicine approaches. His interdisciplinary team science research program focuses on making precision medicine clinically actionable through innovative solutions merging clinical pharmacology knowledge with ‘-omics’ discoveries using microbiome and metabolomics signatures. Part of this work includes translating these findings into improved clinical treat-to-target endpoints with immediate noninvasive point-of-care measures such as intestinal ultrasound.
The foundation of his current work originates from his PhD titled ‘Precision Dosing and Personalized Medicine in pediatric IBD’. During his training, Dr. Colman was also an American Gastroenterological Association (AGA) editorial fellow for Gastroenterology and he is actively involved in the committees of several professional societies including the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), the Crohn’s and Colitis Foundation and the International Bowel UltraSound (IBUS) Group. Dr. Colman is supported by a Career Development K23 Award from the NIH, which focuses on evaluating personalized treatment strategies for children with Crohn's disease, specifically examining microbial and transmural intestinal ultrasound findings. He is also funded by awards of the NASPGHAN Foundation and the Stanford Pediatrics Physician-Scientist Bridge to K Program. -
Le Cong
Associate Professor of Pathology (Pathology Research) and of Genetics
Current Research and Scholarly InterestsOur lab develops gene-editing technologies like novel CRISPR systems and large gene insertion techniques for gene and cell therapy. We also leverage these gene-editing tools for single-cell functional screening to probe mechanisms of cancer, immunological, and aging-associated diseases. To accelerate our work, we integrate AI and machine learning to design and evolve therapeutic RNAs/proteins, and build AI-XR co-scientists like LabOS that bridge AI computation and biomedical experimentation.
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Christopher H. Contag
Professor of Pediatrics (Neonatology), Emeritus
Current Research and Scholarly InterestsWe develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.
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David N. Cornfield
Anne T. and Robert M. Bass Professor of Pediatric Pulmonary Medicine
Current Research and Scholarly InterestsOver the past 20 years, the Cornfield Laboratory has focused upon basic, translational and clinical research, with a primary focus on lung biology. As an active clinician-scientist, delivering care to acutely and chronically ill infants and children, our lab focuses on significant clinical challenges and tried to use science to craft novel solutions to difficult clinical problems.
