School of Medicine
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Pavan Khosla
Graduate, Medicine, School of Medicine
BioM.D. Candidate, Yale School of Medicine, Class of 2027
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Nitasha Khullar, MD
Clinical Assistant Professor, Medicine - Immunology & Rheumatology
BioDr. Nitasha Khullar is a board-certified, fellowship-trained rheumatologist at Stanford Health Care. She is also a clinical assistant professor in the Department of Medicine, Division of Immunology and Rheumatology at Stanford University School of Medicine.
Dr. Khullar specializes in caring for people with autoimmune and inflammatory diseases that affect the joints, muscles, and immune system. She treats conditions like lupus, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, vasculitis, gout and other complex rheumatic disorders. She provides personalized care for each patient, focusing on early diagnosis and working closely with other medical specialists to help manage these diseases. She values shared decision-making and a patient-centric approach to her care.
Dr. Khullar’s work has been presented at national and international conferences, including the American College of Rheumatology and the American Association of Immunology. She has authored peer-reviewed publications in journals such as Viruses, Molecular Neurobiology, Age (Dordrecht, Netherlands), and Current Treatment Options in Rheumatology.
She is a member of the American College of Rheumatology.
