School of Medicine


Showing 1-10 of 62 Results

  • Justin P. Annes M.D., Ph.D.

    Justin P. Annes M.D., Ph.D.

    Associate Professor of Medicine (Endocrinology)

    Current Research and Scholarly InterestsThe ANNES LABORATORY of Molecular Endocrinology: Leveraging Chemical Biology to Treat Endocrine Disorders

    DIABETES
    The prevalence of diabetes is increasing at a staggering rate. By the year 2050 an astounding 25% of Americans will be diabetic. The goal of my research is to uncover therapeutic strategies to stymie the ensuing diabetes epidemic. To achieve this goal we have developed a variety of innovate experimental approaches to uncover novel approaches to curing diabetes.

    (1) Beta-Cell Regeneration: Diabetes results from either an absolute or relative deficiency in insulin production. Our therapeutic strategy is to stimulate the regeneration of insulin-producing beta-cells to enhance an individual’s insulin secretion capacity. We have developed a unique high-throughput chemical screening platform which we use to identify small molecules that promote beta-cell growth. This work has led to the identification of key molecular pathways (therapeutic targets) and candidate drugs that promote the growth and regeneration of islet beta-cells. Our goal is to utilize these discoveries to treat and prevent diabetes.

    (2) The Metabolic Syndrome: A major cause of the diabetes epidemic is the rise in obesity which leads to a cluster of diabetes- and cardiovascular disease-related metabolic abnormalities that shorten life expectancy. These physiologic aberrations are collectively termed the Metabolic Syndrome (MS). My laboratory has developed an original in vivo screening platform t to identify novel hormones that influence the behaviors (excess caloric consumption, deficient exercise and disrupted sleep-wake cycles) and the metabolic abnormalities caused by obesity. We aim to manipulate these hormone levels to prevent the development and detrimental consequences of the MS.

    HEREDIATY PARAGAGLIOMA SYNDROME
    The Hereditary Paraganglioma Syndrome (hPGL) is a rare genetic cancer syndrome that is most commonly caused by a defect in mitochondrial metabolism. Our goal is to understand how altered cellular metabolism leads to the development of cancer. Although hPGL is uncommon, it serves as an excellent model for the abnormal metabolic behavior displayed by nearly all cancers. Our goal is to develop novel therapeutic strategies that target the abnormal behavior of cancer cells. In the laboratory we have developed hPGL mouse models and use high throughput chemical screening to identify the therapeutic susceptibilities that result from the abnormal metabolic behavior of cancer cells.

    As a physician scientist trained in clinical genetics I have developed expertise in hereditary endocrine disorders and devoted my efforts to treating families affected by the hPGL syndrome. By leveraging our laboratory expertise in the hPGL syndrome, our care for individuals who have inherited the hPGL syndrome is at the forefront of medicine. Our goal is to translate our laboratory discoveries to the treatment of affected families.

  • Danit Ariel

    Danit Ariel

    Clinical Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism

    BioDanit Ariel, MD MS, is double board certified in Internal Medicine and Endocrinology. Dr. Ariel graduated from UC Davis School of Medicine. She then completed a residency in Internal Medicine at Stanford and a fellowship and post-doctorate in Endocrinology and Metabolism at Stanford before joining the faculty at Stanford.

    Dr. Ariel practices general endocrinology, with a special interest in thyroid disorders, menopause, LGBTQ+ health, and transgender medicine amongst others.

    She believes in practicing compassionate care: in listening to her patients’ concerns, respecting their values, communicating well, and providing an evidence-based approach to help guide individualized treatment plans. She is deeply committed to utilizing her expertise in the field of endocrinology to optimize her patients’ health and well-being.

    Dr. Ariel is passionate about medical education and teaching, and serves on the teaching faculty in the Stanford University School of Medicine. She completed an honors certificate in medical education from Stanford. She is the Founding Director of the Student Guidance Program for medical students. Finally, within the division of Endocrinology, she is the Director of Faculty Wellness.

    Appointments with with Dr. Ariel are available in the Hoover Pavilion on 211 Quarry Road.

  • Marina Basina

    Marina Basina

    Clinical Professor, Medicine - Endocrinology, Gerontology, & Metabolism

    Current Research and Scholarly InterestsDiabetes type I and type II, insulin pump therapy, glucose sensor technology, insulin resistance, PCOS, thyroid disorders

  • Julia J. Chang, MD

    Julia J. Chang, MD

    Clinical Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism

    BioDr. Chang is a board-certified endocrinologist and internal medicine doctor. She is a Clinical Assistant Professor in Stanford Medicine’s Division of Endocrinology, Gerontology, and Metabolism. She specializes in transgender health, pituitary disorders, diabetes, and general endocrine disorders.

    She provides patient care at the Stanford Health Care Endocrinology Clinic and the Stanford Health Care LGBTQ+ Health Program. For each patient, she develops a comprehensive, compassionate care plan personalized to individual needs. Her goal is always the best possible health and quality of life for every patient in her care.

    Dr. Chang leads quality improvement and education initiatives within the endocrinology and pituitary team. She teaches medical students, residents, and fellows and serves as the endocrinology rotation director for residents and medical students.

    Dr. Chang has conducted extensive research and has published peer-reviewed articles on obesity, weight loss, and transgender health in the journals Endocrine Practice, Family Medicine, and Cleveland Clinic Journal of Medicine. She has presented the findings of her research at national meetings of the Endocrine Society and United States Professional Association of Transgender Health.

    She is a member of the Endocrine Society, American Association of Clinical Endocrinology, Pituitary Society, and the World Professional Association of Transgender Health.

    As a volunteer, Dr. Chang has guided medical students providing health care to uninsured residents of the Bay Area.

    When not providing clinical care, teaching, or conducting research, Dr. Chang enjoys time with her family, violin, golf, figure skating, and travel.

    She is a native English speaker and also understands Korean.

  • Julie Chen

    Julie Chen

    Clinical Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism

    BioJulie Chen, MD, is a clinical assistant professor in endocrinology at Stanford University. Dr. Chen graduated from Albert Einstein College of Medicine. She then completed her internal medicine residency at the University of California, San Diego and endocrinology fellowship at Stanford University Medical Center. She is double board certified in internal medicine and endocrinology.

    Dr. Chen practices general endocrinology but her clinical interest include thyroid disease/thyroid cancer, pituitary disease, and disorders of the bone. She also has a special interest in medical education and has developed online teaching resources for the endocrine fellowship program.