School of Medicine


Showing 1-31 of 31 Results

  • Maya Adam

    Maya Adam

    Clinical Assistant Professor, Pediatrics - Infectious Diseases

    BioDr. Adam is the Director of Health Media Innovation and a Clinical Assistant Professor in the Department of Pediatrics at Stanford School of Medicine. She creates video-based entertainment-education on topics related to maternal child health, nutrition and disease prevention. She has designed and produced online educational content for the Stanford School of Medicine for use in their preclinical programs, continuing medical education programs and global health promotion efforts. She is the creator of five massive open online courses and advisor for Stanford’s Digital Medical Education International Collaborative (Digital MEdIC) in South Africa. Adam is principal investigator on two randomized-controlled trials investigating the impact of digital global health education interventions on health-promoting behaviors. She is also a Faculty Fellow at the Center for Innovation in Global Health and the author of Food, Love, Family: A Practical Guide to Child Nutrition.

  • Manuel R. Amieva

    Manuel R. Amieva

    Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly InterestsMy laboratory studies how bacteria colonize our bodies for long periods of time, and how interactions between bacteria and the epithelial surfaces of the gastrointestinal tract and skin may lead to disease. Epithelial surfaces are the first barrier against infection, but they also where our bodies meet and co-evolve with the microbial world.. Several of our studies have focused on the epithelial junctions as a target for bacterial pathogens. The host epithelium uses its epithelial junctions to form a tight but dynamic barrier with an external surface that is inhospitable to microbial attachment, secretes anti-microbial compounds, and has a rapid rate of self-renewal. The balance in the microbe-epithelial relationship results in silent commensalism or symbiosis; an imbalance results in diseases ranging from acute bacterial invasive disease to chronic ulcers or carcinoma.

    Our laboratory has developed novel microscopy applications such as quantitative 3D confocal microscopy, electron microscopy, time-lapse imaging, microinjection and micromanipulation to visualize the interaction of pathogens with epithelial cells in culture and in animal and human tissues. Many of out studies focus on the gastric pathogen Helicobacter pylori, but we have also expanded our investigations to include the intestinal pathogens Listeria monocytogenes and Salmonella enterica, and the skin pathogen and colonizer Staphylococcus aureus. I believe that elucidating how microbes communicate with and alter our epithelial cells at a molecular level will be important for finding novel therapeutic targets to control mucosal colonization and prevent invasive disease.

    Using this perspective, we have uncovered several novel concepts of how bacteria colonize and breach our epithelial surfaces. For example, we discovered that Helicobacter pylori target the intercellular junctions, and in particular that the virulence factor CagA affects junction assembly and cell polarity. This confers H. pylori the ability to extract nutrients and grow directly on the epithelial surface. We also found that these properties of CagA have consequences for cellular transformation of the epithelium. For instance, we showed that H. pylori affect the activity and state of epithelial stem cells in the stomach by colonizing the epithelial surface deep in the gastric glands. This gland-associated population is essential for pathological inflammation and hyperplasia in animal models, and confers significant colonization advantages to the bacteria. Our Listeria research uncovered a new mechanism and site where bacteria can breach the gastrointestinal epithelial barrier to invade. We found that Listeria find their receptor for invasion at sites of epithelial senescence, where the epithelial junctions undergo dynamic turnover. To study Salmonella and H. pylori we have developed a human organoid model to study their interactions with human gut epithelium in vitro. To study Staphylococcus aureus pathogenesis, we have developed methods to visualize infection at the scale of a single bacterial microcolony using an organoid culture system of human keratinocytes and fibroblasts that grow into a 3D skin-equivalent. We recently identified several proteins at the eptithelial junctions as host factors involved in the pathogenesis of one of Staphylococcus aureus major toxins.

  • Ann M. Arvin

    Ann M. Arvin

    Lucile Salter Packard Professor of Pediatrics and Professor of Microbiology and Immunology, Emerita

    Current Research and Scholarly InterestsOur laboratory investigates the pathogenesis of varicella zoster virus (VZV) infection, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in Scid-hu mouse models of VZV cell tropisms in vivo, and the immunobiology of VZV infections.

  • Sharon F. Chen

    Sharon F. Chen

    Clinical Professor, Pediatrics - Infectious Diseases

    Current Research and Scholarly InterestsMy research interest is in viral infections affecting immunocompromised patients. As Co-director of the Pediatric Infectious Diseases Program for Immunocompromised Hosts, I develop and conduct clinical and translational studies to establish best practices for these patients.
    My education scholarship interests are in refining active learning to improve student learning, to characterize adaptive expertise of physicians, and to create a tool that assesses "thinking": Stanford CASE

  • Despina Contopoulos-Ioannidis, MD

    Despina Contopoulos-Ioannidis, MD

    Clinical Associate Professor, Pediatrics - Infectious Diseases

    Current Research and Scholarly InterestsEvidence based medicine: Systematic reviews, Meta-analyses
    Congenital Infections-Prenatal Screening with Point-Of-Care Tests
    Congenital Toxoplasmosis
    Comparative effectiveness-Comparative safety research
    Outcomes research (Patient safety)
    Antimicrobial Stewardship
    Early Life Antibiotic Use and Weight Gain

  • Cornelia L. Dekker, M.D.

    Cornelia L. Dekker, M.D.

    Professor (Research) of Pediatrics (Infectious Diseases), Emerita

    Current Research and Scholarly InterestsThe Stanford-LPCH Vaccine Program provides an infrastructure for conducting clinical studies of vaccines in children and adults. We conduct immunology studies of seasonal influenza vaccines in twins, in a longitudinal cohort of young and elderly adults and studies of various vaccine candidates for NIH and industry. Additionally, we were a CDC Clinical Immunization Safety Assessment site for 10 years working on safety issues concerning licensed vaccines.

  • Elizabeth Egan

    Elizabeth Egan

    Assistant Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly InterestsMalaria is a parasitic disease transmitted by mosquitos that is a leading cause of childhood mortality globally. Public health efforts to control malaria have historically been hampered by the rapid development of drug resistance. The goal of our research is to understand the molecular determinants of critical host-pathogen interactions in malaria, with a focus on the erythrocyte host cell. Our long-term goal is to develop novel approaches to prevent or treat malaria and improve child health.

  • Hayley Gans

    Hayley Gans

    Clinical Professor, Pediatrics - Infectious Diseases

    Current Research and Scholarly InterestsThe focus of my laboratory is the immune response to viral vaccines evaluating the ontogeny of responses in infants and limitations in immunocompromised hosts. We have studied responses to an early two-dose measles immunization, one versus 2 doses of varicella immunization, and polio vaccine in preterm versus term infants. Other active areas of research include measles and varicella immunity in HIV infected individuals, and transplant recipients.

  • Torsten Joerger

    Torsten Joerger

    Clinical Assistant Professor, Pediatrics - Infectious Diseases

    BioTorsten Joerger, MD, MSCE, is a Clinical Assistant Professor in the Division of Infectious Diseases in the Department of Pediatrics. He serves as the Associate Medical Director of the Antimicrobial Stewardship Program at Stanford Lucile Packard Children’s Hospital. His research interests center around the optimal use of antimicrobials in children as well as clinical epidemiological studies of infections in children.

  • Angelle Desiree LaBeaud

    Angelle Desiree LaBeaud

    Professor of Pediatrics (Infectious Diseases), Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Epidemiology and Population Health

    Current Research and Scholarly InterestsArthropod-borne viruses are emerging and re-emerging infections that are spreading throughout the world. Our laboratory investigates the epidemiology of arboviral infections, focusing on the burden of disease and the long-term complications on human health. In particular, Dr. LaBeaud investigates dengue, chikungunya, and Rift Valley fever viruses in Kenya, where outbreaks cause fever, arthritis, retinitis, encephalitis, and hemorrhagic fever. Our main research questions focus on the risk factors for arboviral infections, the development of diagnostic tests that can be administered in the field to quickly determine what kind of arboviral infection a person has, and the genetic and immunologic investigation of why different people respond differently to the same infection. Our long-term goals are to contribute to a deeper understanding of arboviral infections and their long-term health consequences and to optimize control strategies to prevent these emerging infections. Our laboratory also investigates the effects of antenatal and postnatal parasitic infections on vaccine responses, growth, and development of Kenyan children.

    My lab at Stanford supports the field work that is ongoing in Kenya, but we also have several projects that are based locally. We strive to improve diagnostics of arboviral infections and are using Luminex technology to build a new screening assay. We also have created a Luminex based platform to assess vaccine responses against multiple pathogens.

  • Grace Lee

    Grace Lee

    Professor of Pediatrics (Infectious Diseases)

    BioDr. Grace Lee is Professor of Pediatrics at Stanford University School of Medicine and Associate Chief Medical Officer for Practice Innovation at Stanford Children’s Health. In her current role, Dr. Lee primarily serves as a clinical and administrative leader for the health system focused on bridging quality, research and implementation for the organization. She previously served as the Principal Investigator (PI) on the CDC-funded Vaccine Safety Datalink project, Associate Director of the FDA-funded Mini-Sentinel Project, PI of an AHRQ-funded grant to develop a national surveillance definition for pediatric ventilator-associated events and to identify potential intervention bundles to improve quality of care, and PI of an AHRQ-funded grant to evaluate the health and economic impact of the CMS Hospital-Acquired Conditions and Value-Based Purchasing policies. Dr. Lee previously served as a member on the Institute of Medicine Committee (IOM) to Review Priorities in the National Vaccine Plan, the IOM Committee on the Ethical and Scientific Issues in Studying the Safety of Approved Drugs, NASEM's Vaccine Research and Development Recommendations for Advancing Pandemic and Seasonal Influenza Preparedness and Response, and AHRQ's Healthcare Safety and Quality Improvement Research Study Section. Dr. Lee also served as a Board Member for the Society for Healthcare Epidemiology of America (SHEA), Pediatric Infectious Diseases Society (PIDS), and the National Academy of Medicine Board on Population Health and Public Practice. She is currently the Chair of the U.S. Advisory Committee on Immunization Practices (ACIP) that sets recommendations for the use of vaccines in the U.S. population, including COVID-19 vaccines.

  • Yvonne Maldonado

    Yvonne Maldonado

    Senior Associate Dean, Faculty Development and Diversity, Taube Professor of Global Health and Infectious Diseases, Professor of Pediatrics (Infectious Diseases) and of Epidemiology and Population Health

    Current Research and Scholarly InterestsMy research focuses on epidemiologic aspects of viral vaccines and perinatal HIV infection. This includes the molecular epidemiology of factors affecting the immunogenicity of oral polio vaccine (OPV) in developing areas of the world, and now the epidemiology of transmission and circulation of vaccine derived polioviruses in order to assist in global eradication of polio. I also work in development of methods to prevent breastfeeding transmission of HIV in Africa.

  • Benjamin Pinsky

    Benjamin Pinsky

    Associate Professor of Pathology and of Medicine (Infectious Diseases) and, by courtesy, of Pediatrics (Infectious Diseases)

    Current Research and Scholarly InterestsDevelopment and application of molecular assays for the diagnosis and management of infectious diseases.

  • Philip A. Pizzo, M.D.

    Philip A. Pizzo, M.D.

    David and Susan Heckerman Professor and Professor of Microbiology and Immunology
    On Leave from 07/15/2021 To 12/17/2021

    BioPhilip Pizzo, MD, is the David and Susan Heckerman Professor and Founding Director of the Stanford Distinguished Careers Institute. Pizzo served as Dean of the Stanford School of Medicine from April 2001 to December 1, 2012, where he was also the Carl and Elizabeth Naumann Professor of Pediatrics and of Microbiology and Immunology. Dr. Pizzo has devoted much of his distinguished medical career to the diagnosis, management, prevention and treatment of childhood cancers and the infectious complications that occur in children whose immune systems are compromised by cancer and AIDS. He has also been a leader in academic medicine, championing programs and policies to improve the future of science, education and healthcare in the US and beyond.
    Pizzo received his MD degree with Honors and Distinction in Research from the University of Rochester in 1970, and completed an internship and residency at Children’s Hospital Medical Center in Boston, a teaching fellowship at Harvard Medical School, and a clinical and research fellowship in pediatric oncology at the National Cancer Institute. Pizzo served as head of the Institute’s infectious disease section, chief of the NCI’s pediatric department, and acting scientific director for NCI’s Division of Clinical Sciences between 1973 and 1996. Before joining Stanford in 2001, he was the physician-in-chief of Children’s Hospital in Boston and Chair of the Department of Pediatrics at Harvard Medical School, where he was also the Thomas Morgan Rotch Professor of Pediatrics.
    Dr. Pizzo is the author of more than 615 scientific articles and 16 books and monographs, including Principles and Practice of Pediatric Oncology, the Seventh Edition of which was published in 2015.
    Pizzo has received numerous awards and honors, among them the Public Health Service Outstanding Service Medal in 1995, the Barbara Bohen Pfiefer Award for Scientific Excellence in 1991, the Elizabeth Kubler-Ross Award in 2008, the Ronald McDonald Charities “Award of Excellence” in 2009, and the John and Emma Bonica Public Service Award in 2013. He is the 2012 recipient of the John Howland Award, the highest honor for lifetime achievement bestowed by the American Pediatric Society. He has been elected to a number of prestigious organizations and societies, including the Association of American Physicians, the American Society of Clinical Investigation, the American Pediatric Society and the Institute of Medicine of the National Academy of Sciences, where he was also elected to the Governing Council. The IOM became the National Academy of Medicine in 2015. He has served as Chair of the Association of Academic Health Centers and Chair of the Council of Deans of the Association of American Medical Colleges, and was elected to the Board of Directors of the American Society for Clinical Oncology and the Infectious Diseases Society of America. He was President of the International Immunocompromised Host Society (1998-2011). He served on the Governing Board for the California Institute of Regenerative Medicine from 2004-2012. In 2009 he was elected to the Board of Trustees of the University of Rochester and the Board of Overseers of Koc University in Istanbul, Turkey. He was a member of the Board of Directors of MRI Interventions (2013-2017) and the Academic Advisory Council for Merritt Hawkins (2015-present). In 2014 he was elected to the Board of Directors of the Ludwig Institute for Cancer Research and in 2015 he was elected to the Board of Directors of Global Blood Therapeutics. He also serves as Editor-in-Chief of Current Opinion in Pediatrics.

  • Charles G. Prober, MD

    Charles G. Prober, MD

    Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly InterestsMy research interest is in the epidemiology, pathophysiology, prevention, and treatment of infections in children. Much of this research has focused on viral infections, especially those caused by herpes simplex virus (HSV). I have conducted a number of studies concerned with the epidemiology of HSV-2 infections in pregnant women, their partners, and neonates.

  • Clea Sarnquist, DrPH, MPH

    Clea Sarnquist, DrPH, MPH

    Clinical Associate Professor, Pediatrics - Infectious Diseases

    BioDr. Sarnquist focuses on applied teaching and research on the development, implementation and evaluation of interventions to decrease gender-based violence and prevent HIV infection, especially among adolescents and children. She is particularly interested in rights-based approaches that tackle the complex interplay of factors that lead to poor health for many children and families. All of her work is applied, with direct links health practice and policy, and usually performed in conjunction with non-governmental organization and government partners. She works both globally and in the U.S., with a focus on sub-Saharan Africa.

  • Talal Seddik

    Talal Seddik

    Clinical Assistant Professor, Pediatrics - Infectious Diseases

    Current Research and Scholarly InterestsTalal Seddik is a member of the Collaborative Antiviral Study Group. He is running the Stanford site for two national and international studies:

    1) DMID 19-0026 Enterovirus Study
    Neonatal Enterovirus and Human Parechovirus Viral Sepsis: Natural History and Predictors of Morbidity and Mortality

    This study will be the first large, multi-state prospective assessment of the viral causes of neonatal sepsis conducted. The main reason for this research study is to get a better understanding of what causes neonatal viral sepsis and to assess the impact of the infection on the babies’ health. Viruses called enterovirus (EV) or human parechovirus (HPeV) are very common in the population and can cause neonatal viral sepsis. By gaining a better understanding of the condition, we hope this information can be used to guide diagnosis and treatment of babies with neonatal viral sepsis in the future.

    This study is actively enrolling subjects

    2) DMID 19-0005 Acute Flaccid Myelitis (AFM) Study
    A Prospective Study of Acute Flaccid Myelitis (AFM) to Define Natural History, Risk Factors and Pathogenetic Mechanisms

    Patients with suspected AFM (onset of flaccid limb weakness within the previous 30 days) are eligible to enroll in the study. Investigators will assess participants at four-time points within the first month of enrollment and will ask participants to return for additional follow up visits at 3 months, 7 months and 1 year. Neurologic improvements will be tracked over time, and samples will be collected and stored in a biorepository for use in future research studies. Household contacts, such as siblings, will be eligible to participate in the study as a control or comparison group.

    This study is actively enrolling subjects.

  • David Vu

    David Vu

    Instructor, Pediatrics - Infectious Diseases

    BioDr. Vu is a pediatric infectious diseases specialist who is researching human responses to dengue virus and malaria infections. He performed his undergraduate studies at the University of California, San Diego, and obtained his medical doctorate at the University of Pennsylvania School of Medicine. He trained in general pediatrics at UCSF Benioff Children's Hospital Oakland, and in pediatric infectious diseases at Emory University School of Medicine. His present studies on pediatric dengue and malaria co-infection are supported by an NIAID Career Development Award (K23 AI127909) and a Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics.