School of Medicine
Showing 1-29 of 29 Results
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Maya Adam
Clinical Associate Professor, Pediatrics - Infectious Diseases
BioDr. Adam is the Director of Health Media Innovation and a Clinical Associate Professor in the Department of Pediatrics at Stanford School of Medicine. Her research focuses on measuring the impact of innovative, video-based entertainment-education approaches to global health communication. She produces short, animated films and online courses on topics related to maternal child health, nutrition, mental health and disease prevention. She has designed and produced online educational content for the Stanford School of Medicine for use in their preclinical programs, continuing medical education programs and global health promotion efforts. She is the Faculty Lead for the Global Child Health Media Initiative and Associate Director of the Center for Digital Health at Stanford. She is also the lead instructor of eight massive open online courses reaching more than a million learners around the world. Adam is principal investigator on two randomized-controlled trials investigating the impact of digital global health education interventions on health-promoting behaviors. Her research is conducted in collaboration with the Heidelberg Institute of Global Health in Heidelberg, Germany. She is a Faculty Fellow at the Center for Innovation in Global Health and the author of Food, Love, Family: A Practical Guide to Child Nutrition.
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Manuel R. Amieva
Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsMy laboratory studies how bacteria colonize our bodies for long periods of time, and how interactions between bacteria and the epithelial surfaces of the gastrointestinal tract and skin may lead to disease. Epithelial surfaces are the first barrier against infection, but they also where our bodies meet and co-evolve with the microbial world.. Several of our studies have focused on the epithelial junctions as a target for bacterial pathogens. The host epithelium uses its epithelial junctions to form a tight but dynamic barrier with an external surface that is inhospitable to microbial attachment, secretes anti-microbial compounds, and has a rapid rate of self-renewal. The balance in the microbe-epithelial relationship results in silent commensalism or symbiosis; an imbalance results in diseases ranging from acute bacterial invasive disease to chronic ulcers or carcinoma.
Our laboratory has developed novel microscopy applications such as quantitative 3D confocal microscopy, electron microscopy, time-lapse imaging, microinjection and micromanipulation to visualize the interaction of pathogens with epithelial cells in culture and in animal and human tissues. Many of out studies focus on the gastric pathogen Helicobacter pylori, but we have also expanded our investigations to include the intestinal pathogens Listeria monocytogenes and Salmonella enterica, and the skin pathogen and colonizer Staphylococcus aureus. I believe that elucidating how microbes communicate with and alter our epithelial cells at a molecular level will be important for finding novel therapeutic targets to control mucosal colonization and prevent invasive disease.
Using this perspective, we have uncovered several novel concepts of how bacteria colonize and breach our epithelial surfaces. For example, we discovered that Helicobacter pylori target the intercellular junctions, and in particular that the virulence factor CagA affects junction assembly and cell polarity. This confers H. pylori the ability to extract nutrients and grow directly on the epithelial surface. We also found that these properties of CagA have consequences for cellular transformation of the epithelium. For instance, we showed that H. pylori affect the activity and state of epithelial stem cells in the stomach by colonizing the epithelial surface deep in the gastric glands. This gland-associated population is essential for pathological inflammation and hyperplasia in animal models, and confers significant colonization advantages to the bacteria. Our Listeria research uncovered a new mechanism and site where bacteria can breach the gastrointestinal epithelial barrier to invade. We found that Listeria find their receptor for invasion at sites of epithelial senescence, where the epithelial junctions undergo dynamic turnover. To study Salmonella and H. pylori we have developed a human organoid model to study their interactions with human gut epithelium in vitro. To study Staphylococcus aureus pathogenesis, we have developed methods to visualize infection at the scale of a single bacterial microcolony using an organoid culture system of human keratinocytes and fibroblasts that grow into a 3D skin-equivalent. We recently identified several proteins at the eptithelial junctions as host factors involved in the pathogenesis of one of Staphylococcus aureus major toxins. -
Ann M. Arvin
Lucile Salter Packard Professor of Pediatrics and Professor of Microbiology and Immunology, Emerita
Current Research and Scholarly InterestsOur laboratory investigates the pathogenesis of varicella zoster virus (VZV) infection, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in Scid-hu mouse models of VZV cell tropisms in vivo, and the immunobiology of VZV infections.
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Sharon F. Chen
Clinical Professor, Pediatrics - Infectious Diseases
Current Research and Scholarly InterestsMy research interest is in viral infections affecting immunocompromised patients. As Co-director of the Pediatric Infectious Diseases Program for Immunocompromised Hosts, I develop and conduct clinical and translational studies to establish best practices for these patients.
My education scholarship interests are in refining active learning to improve student learning, to characterize adaptive expertise of physicians, and to create a tool that assesses "thinking": Stanford CASE -
Cornelia L. Dekker, M.D.
Professor (Research) of Pediatrics (Infectious Diseases), Emerita
Current Research and Scholarly InterestsThe Stanford-LPCH Vaccine Program provides an infrastructure for conducting clinical studies of vaccines in children and adults. We conduct immunology studies of seasonal influenza vaccines in twins, in a longitudinal cohort of young and elderly adults and studies of various vaccine candidates for NIH and industry. Additionally, we were a CDC Clinical Immunization Safety Assessment site for 10 years working on safety issues concerning licensed vaccines.
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Elizabeth Egan
Assistant Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsMalaria is a parasitic disease transmitted by mosquitos that is a leading cause of childhood mortality globally. Public health efforts to control malaria have historically been hampered by the rapid development of drug resistance. The goal of our research is to understand the molecular determinants of critical host-pathogen interactions in malaria, with a focus on the erythrocyte host cell. Our long-term goal is to develop novel approaches to prevent or treat malaria and improve child health.
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Hayley Gans
Clinical Professor, Pediatrics - Infectious Diseases
Current Research and Scholarly InterestsThe focus of my laboratory is the immune response to viral vaccines evaluating the ontogeny of responses in infants and limitations in immunocompromised hosts. We have studied responses to an early two-dose measles immunization, one versus 2 doses of varicella immunization, and polio vaccine in preterm versus term infants. Other active areas of research include measles and varicella immunity in HIV infected individuals, and transplant recipients.
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Angelle Desiree LaBeaud
Professor of Pediatrics (Infectious Diseases), Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Epidemiology and Population Health and at the Stanford Doerr School of Sustainability
Current Research and Scholarly InterestsArthropod-borne viruses are emerging and re-emerging infections that are spreading throughout the world. Our laboratory investigates the epidemiology of arboviral infections, focusing on the burden of disease and the long-term complications on human health. In particular, Dr. LaBeaud investigates dengue, chikungunya, and Rift Valley fever viruses in Kenya, where outbreaks cause fever, arthritis, retinitis, encephalitis, and hemorrhagic fever. Our main research questions focus on the risk factors for arboviral infections, the development of diagnostic tests that can be administered in the field to quickly determine what kind of arboviral infection a person has, and the genetic and immunologic investigation of why different people respond differently to the same infection. Our long-term goals are to contribute to a deeper understanding of arboviral infections and their long-term health consequences and to optimize control strategies to prevent these emerging infections. Our laboratory also investigates the effects of antenatal and postnatal parasitic infections on vaccine responses, growth, and development of Kenyan children.
My lab at Stanford supports the field work that is ongoing in Kenya, but we also have several projects that are based locally. We strive to improve diagnostics of arboviral infections and are using Luminex technology to build a new screening assay. We also have created a Luminex based platform to assess vaccine responses against multiple pathogens. -
Grace Lee
Professor of Pediatrics (Infectious Diseases)
BioDr. Grace Lee is Chief Quality Officer and the Christopher G. Dawes Endowed Director of Quality at Stanford Medicine Children’s Health and Lucile Packard Children’s Hospital Stanford, and Associate Dean for Maternal and Child Health (Quality and Safety) and Professor of Pediatrics at Stanford University School of Medicine. She oversees the Center for Pediatric and Maternal Value that seeks to improve quality, safety, patient experience and health equity across the organization. Dr. Lee previously served as a member of the Institute of Medicine Committee (IOM) to Review Priorities in the National Vaccine Plan, the IOM Committee on the Ethical and Scientific Issues in Studying the Safety of Approved Drugs, the National Academies of Sciences, Engineering, and Medicine (NASEM) Committee on Vaccine Research and Development Recommendations for Advancing Pandemic and Seasonal Influenza Preparedness and Response, and AHRQ's Healthcare Safety and Quality Improvement Research Study Section. She also served as a Board Member for the Society for Healthcare Epidemiology of America (SHEA), Pediatric Infectious Diseases Society (PIDS), and the National Academy of Medicine (NAM) Board on Population Health and Public Health Practice. She was previously the Chair of the U.S. Advisory Committee on Immunization Practices (ACIP) that recommends vaccines for the U.S. population, and she is an elected member of the National Academy of Medicine.
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Yvonne Maldonado
Senior Associate Dean, Faculty Development and Diversity, Taube Professor of Global Health and Infectious Diseases, Professor of Pediatrics (Infectious Diseases) and of Epidemiology and Population Health
Current Research and Scholarly InterestsMy research focuses on epidemiologic aspects of viral vaccines and perinatal HIV infection. This includes the molecular epidemiology of factors affecting the immunogenicity of oral polio vaccine (OPV) in developing areas of the world, and now the epidemiology of transmission and circulation of vaccine derived polioviruses in order to assist in global eradication of polio. I also work in development of methods to prevent breastfeeding transmission of HIV in Africa.
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Trung Hoang Minh Pham
Assistant Professor of Pediatrics (Infectious Diseases)
Current Research and Scholarly InterestsUncovering mechanisms of tissue immunity and immunophysiology during persistent infection
The immune system safeguards the health of complex organisms by rapidly eliminating invading pathogens, curbing infection-induced tissue disruptions, and maintaining tissue homeostasis. Many bacterial pathogens evade host antimicrobial mechanisms and persist in infected tissues at low levels for long periods of time even in the presence of innate and adaptive immune resistance. During persistent infection, the immune system simultaneously orchestrates antimicrobial responses to contain the pathogen, repairs damaged tissue, regulates nutrient resources, and maintains other tissue physiologic functions to ensure host survival. Failure of any of these tasks leads to uncontrolled infection, devastating disease, and even death. The goals of our research are to understand:
1)What are the innate and adaptive immune cellular mechanisms that contain pathogens during persistent infection?
2)How are tissue physiological functions, such as tissue repair and nutrient regulation, maintained during persistent infection?
3)How do pathogens survive innate and adaptive antimicrobial mechanisms in infected tissues?
4)How does persistent infection impact host immunity to secondary infections of a similar or different pathogen?
Through investigating these fundamental questions, we may be able to decode the underlying cellular and molecular mechanisms that can be harnessed to eradicate infections and help restore health after an infectious insult. We employ animal infection models and bring together immunology, tissue biology, microbiology, and genetics to uncover the mechanisms of tissue immunity and immunophysiology during persistent infection from the molecular to organismal level.
Current areas of research:
•Development, maintenance, and plasticity of macrophage functional diversity in infected tissue
•Tissue repair and nutrient regulation during persistent infection
•Cellular dynamics and bacterial persistence in lymphoid organs
We are looking for highly motivated team members who are passionate about making impactful scientific discoveries to join our group at all levels. For opportunities and positions available for pre-doctoral students and postdoctoral fellows, please contact tpham8@stanford.edu! -
Benjamin Pinsky
Professor of Pathology, of Medicine (Infectious Diseases) and, by courtesy, of Pediatrics (Infectious Diseases)
Current Research and Scholarly InterestsDevelopment and application of molecular assays for the diagnosis and management of infectious diseases.
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Charles G. Prober, MD
Professor of Pediatrics (Infectious Diseases) and, by courtesy, of Microbiology and Immunology
Current Research and Scholarly InterestsMy research interest is in the epidemiology, pathophysiology, prevention, and treatment of infections in children. Much of this research has focused on viral infections, especially those caused by herpes simplex virus (HSV). I have conducted a number of studies concerned with the epidemiology of HSV-2 infections in pregnant women, their partners, and neonates.
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Clea Sarnquist, DrPH, MPH
Clinical Associate Professor, Pediatrics - Infectious Diseases
Clinical Associate Professor (By courtesy), Epidemiology and Population HealthBioDr. Sarnquist focuses on applied teaching and research on the development, implementation and evaluation of interventions to decrease gender-based violence and prevent HIV infection, especially among adolescents and children. She is particularly interested in rights-based approaches that tackle the complex interplay of factors that lead to poor health for many children and families. All of her work is applied, with direct links health practice and policy, and usually performed in conjunction with non-governmental organization and government partners. She works both globally and in the U.S., with a focus on sub-Saharan Africa. She is also a medical educator, directing the scholarly concentrations program of the pediatric residency at Stanford, and co-directing the global health concentration for residents
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Talal Seddik
Clinical Associate Professor, Pediatrics - Infectious Diseases
Current Research and Scholarly InterestsTalal Seddik is a member of the Collaborative Antiviral Study Group. He is the key site investigator at the Stanford site for the following multicenter studies:
1) DMID 19-0026 Enterovirus Study
Neonatal Enterovirus and Human Parechovirus Viral Sepsis: Natural History and Predictors of Morbidity and Mortality
This study will be the first large, multi-state prospective assessment of the viral causes of neonatal sepsis conducted. The main reason for this research study is to get a better understanding of what causes neonatal viral sepsis and to assess the impact of the infection on the babies’ health. Viruses called enterovirus (EV) or human parechovirus (HPeV) are very common in the population and can cause neonatal viral sepsis. By gaining a better understanding of the condition, we hope this information can be used to guide diagnosis and treatment of babies with neonatal viral sepsis in the future.
This study is actively enrolling subjects
2) DMID 19-0005 Acute Flaccid Myelitis (AFM) Study
A Prospective Study of Acute Flaccid Myelitis (AFM) to Define Natural History, Risk Factors and Pathogenetic Mechanisms
Patients with suspected AFM (onset of flaccid limb weakness within the previous 30 days) are eligible to enroll in the study. Investigators will assess participants at four-time points within the first month of enrollment and will ask participants to return for additional follow up visits at 3 months, 7 months and 1 year. Neurologic improvements will be tracked over time, and samples will be collected and stored in a biorepository for use in future research studies. Household contacts, such as siblings, will be eligible to participate in the study as a control or comparison group.
This study is actively enrolling subjects. -
David Vu
Clinical Associate Professor, Pediatrics - Infectious Diseases
BioDr. Vu is a pediatric infectious diseases specialist who is researching human responses to dengue virus and malaria infections. He performed his undergraduate studies at the University of California, San Diego, and obtained his medical doctorate at the University of Pennsylvania School of Medicine. He trained in general pediatrics at UCSF Benioff Children's Hospital Oakland, and in pediatric infectious diseases at Emory University School of Medicine. His present studies on pediatric dengue and malaria co-infection are supported by an NIAID Career Development Award (K23 AI127909) and a Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics.
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Dean Winslow
Professor of Medicine (Hospital Medicine), by courtesy, of Pediatrics (Infectious Diseases) and Senior Fellow, by courtesy, at the Freeman Spogli Institute for International Studies
BioDean Winslow, MD is Professor of Medicine and Pediatrics and is a Senior Fellow (courtesy) at CISAC/Freeman Spogli Institute. He has served on the Stanford faculty since 1998 and from 2003-2008 as Co-Director of Stanford's Infectious Diseases Fellowship Training Program. He was in private practice in Wilmington, Delaware where he started the state’s first multidisciplinary clinic for HIV patients in 1985. In 1988 he joined the DuPont Company where he worked both as a bench scientist on HIV drug resistance then designed the clinical trials supporting FDA approval of efavirenz. In 1999 he became Vice President of Regulatory Affairs at Visible Genetics Inc. and led the FDA clearance of the TRUGENE HIV-1 drug resistance test. Dr. Winslow joined the staff at Santa Clara Valley Medical Center in 2003, where he served as Chief of the Division of AIDS Medicine and later as Chair of the Department of Medicine. In 2015 he was appointed Vice Chair of the Department of Medicine at Stanford and Academic Physician-In-Chief at Stanford/ValleyCare. He was a Resident Fellow in Robinson House 2013-2017 and was visiting faculty at Oxford University in 2017. He was Lead Physician for the US Antarctic Program of the National Science Foundation 2019-2020 based at McMurdo Station, Antarctica. In 2021 he took leave from Stanford to lead the US COVID-19 Testing and Diagnostic Working Group. He also served as CDC Senior Advisor to Operation ALLIES WELCOME and Chief Medical Officer for the Southwest Border Migrant Health Task Force before returning to Stanford in July 2022.
Dr. Winslow is a Master of the American College of Physicians, Fellow of the Royal College of Physicians, the Infectious Diseases Society of America, and the Pediatric Infectious Diseases Society. He is the author of 94 papers. He is,a member of the IDSA Sepsis Task Force, and previously served as Chair of the Standards and Practice Guidelines Committee.
Colonel Winslow entered the Air National Guard in 1980 and was a Distinguished Graduate of the USAF School of Aerospace Medicine. He served as Commander of the 159th Medical Group 1992-1995 and was State Air Surgeon, Delaware Air National Guard 1995-2011. He served as ANG Assistant to the Commander, 59th Medical Wing, Joint Base San Antonio 2011-2014. Colonel Winslow deployed to the Middle East six times after 9/11 as a flight surgeon supporting combat operations in Iraq and Afghanistan. From Jan-April 2003 Colonel Winslow was the flight surgeon responsible for combat rescue operations from northern Iraq to Tikrit. In 2005 he coordinated military public health in Louisiana in the aftermath of Hurricane Katrina. In 2006 Colonel Winslow served as an ER physician at the United States Air Force 447th EMEDS (combat hospital) in Baghdad and in 2008 he served as hospital commander during the Iraq surge. He is a 2007 graduate of Air War College. He served as an infectious disease consultant to the USAF Surgeon General. In 2017 Dr. Winslow was nominated by the President to serve as Assistant Secretary of Defense for Health Affairs. He has 3,000 civilian and 1150 military flying hours including 431 combat hours and 263 combat sorties. He has extensive operational experience in fighter, tactical airlift, and combat rescue missions. He holds an FAA Airline Transport Pilot license.
Since 2006 Dr. Winslow has arranged medical care in the U.S. for 28 Iraqi children who have complicated medical conditions for which care is not available in Iraq. In 2015, Dr. Winslow and his wife, Dr. Julie Parsonnet, created The Eagle Fund of the Silicon Valley Community Foundation, which provides aid to middle eastern and central American refugees. In 2018 he co-founded Scrubs Addressing the Firearms Epidemic (SAFE), which unites health care professionals to address gun violence in the US as a public health issue and to advocate for education, research, and evidence-backed policy to reduce gun violence.
