School of Medicine
Showing 51-100 of 125 Results
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Cheng Liu
Postdoctoral Scholar, Molecular and Cellular Physiology
Current Research and Scholarly InterestsFun & joy in open science
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Martin J. Lohse
Visiting Professor, Molecular & Cellular Physiology
BioMartin Lohse studied medicine and philosophy at the universities of Göttingen (Germany), London (UK) and Paris (France). From 1978 to 1981 he did his MD thesis in the Department of Neurobiology at the Max Planck Institute of Biophysical Chemistry with Otto Creutzfeldt and Wolfgang Wuttke investigating the central nervous system effects of endogenous opiates. He was a postdoc in pharmacology with Ulrich Schwabe at the University of Heidelberg, and then with Robert J. Lefkowitz (HHMI, Duke University), where he later became an Assistant Professor. From Duke he moved to his first independent lab at the Gene Center in Munich/Martinsried, a new research center operated jointly by the Max Planck Institute for Biochemistry and the University of Munich. In 1993, he became Chair of the Institute of Pharmacology and Toxicology at the University of Würzburg, and remained a professor at this university until his retirement in 2022. In Würzburg, he founded the Rudolf Virchow Center, the DFG Research Center for Experimental Biomedicine (2001-2016), and he became also the founding director of the University of Würzburg Graduate School (2003-2016).
From 2016 to 2019 he served as Chairman of the Max Delbrück Center in Berlin, a national research center for molecular medicine. In 2020, while keeping his lab in Berlin, he moved back to Bavaria to establish and lead the new start-up institute/incubator ISAR Bioscience in Munich/Planegg, that aims to use stem cell technologies to advance academic projects towards clinical applications and to foster the formation of start-up companies.
Martin Lohse has accepted many public and professional service duties. He was a member of the German National Ethics Council, Vice President for Research of the University of Würzburg, Vice President of the German National Academy of Sciences Leopoldina, and President of the Society of German Natural Scientists and Physicians GDNÄ. He has been a member and chair of numerous scientific advisory boards across Europe. He holds honorary, senior and distinguished professorships at the Free University of Berlin, the University of Leipzig, and the Technical University of Munich TUM. At the Department for Molecular and Cellular Physiology of Stanford University he collaborates with the teams of Brian Kobilka and Ruth Hüttenhain to probe the local environment of receptors and its function and regulation. -
Daniel V. Madison
Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsOur underlying forms of activity-dependent synaptic plasticity such as long-term potentiation and long-term depression, and in particular the function and plasticity of Parvalbumin-containing interneurons in neocortex. In the past few years, we have used a combinatorial approach to comparing physiological and anatomical plasticity-induced changes in synapses using electrode recording and Array Tomography in the same neurons.
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Merritt Maduke
Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMolecular mechanisms of ion chnanels & transporters studied by integration of structural and electrophysiological methods.
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Alejandro Matia
Postdoctoral Scholar, Molecular and Cellular Physiology
BioAlejandro Matía conducted his PhD research at the Spanish National Research Council (CSIC), employing multi-omic technologies such as CRISPR genetic screens to detect new host factors in Poxvirus infections. His interest in Bioinformatics led to the creation of MaGplotR, a tool designed for the analysis of multiple genetic screens. Alejandro also has experience in long-read sequencing, and he has sequenced different viral genomes such as Vaccinia virus, Monkeypox virus and SARS-CoV-2. Alejandro was a visiting scientist at the Chan Zuckerberg Biohub (San Francisco) where he conducted single cell transcriptomics experiments with Poxvirus. Currently, Alejandro leverages his omics expertise to unravel the intricate mechanisms of opioid receptor physiology.
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Lucy Erin O'Brien
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMany adult organs tune their functional capacity to variable levels of physiologic demand. Adaptive organ resizing breaks the allometry of the body plan that was established during development, suggesting that it occurs through different mechanisms. Emerging evidence points to stem cells as key players in these mechanisms. We use the Drosophila midgut, a stem-cell based organ analogous to the vertebrate small intestine, as a simple model to uncover the rules that govern adaptive remodeling.
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Tino Pleiner
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsThe Pleiner lab combines mechanistic cell biology, structural biochemistry and protein engineering to dissect the pathways and molecular machines that mature human membrane proteins to a fully functional state. We also develop alpaca-derived and synthetic nanobodies as tools to modulate intracellular pathways that globally regulate protein homeostasis in health and disease.
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Anthony J. Ricci, PhD
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy of Molecular and Cellular Physiology
Current Research and Scholarly InterestsThe auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.
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Georgios Skiniotis
Professor of Molecular and Cellular Physiology, of Structural Biology and of Photon Science
BioThe Skiniotis laboratory seeks to resolve structural and mechanistic questions underlying biological processes that are central to cellular physiology. Our investigations employ primarily cryo-electron microscopy (cryoEM) and 3D reconstruction techniques complemented by biochemistry, biophysics and simulation methods to obtain a dynamic view into the macromolecular complexes carrying out these processes. The main theme in the lab is the structural biology of cell surface receptors that mediate intracellular signaling and communication. Our current main focus is the exploration of the mechanisms responsible for transmembrane signal instigation in cytokine receptors and G protein coupled receptor (GPCR) complexes.
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Stephen J Smith
Professor of Molecular and Cellular Physiology, Emeritus
Current Research and Scholarly InterestsStephen Smith remains active in the computational microscopy field and is also currently using data science tools to explore new transcriptomic perspectives on signaling by neuropeptides and other neuromodulators in brains of diverse animal species. These exploration have unearthed evidence for a previous unrecognized ubiquity of local neuropeptide signaling and possible critical involvement of such signaling in memory engram formation.