School of Medicine
Showing 271-280 of 306 Results
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Douglas Vollrath
Professor of Genetics and, by courtesy, of Ophthalmology
Current Research and Scholarly InterestsThe Vollrath lab works to uncover molecular mechanisms relevant to the health and pathology of the outer retina. We study metabolic and other cellular interactions between the glial-like retinal pigment epithelium (RPE) and adjacent photoreceptors, with the goals of understanding the pathogenesis of photoreceptor degenerative diseases such as age-related macular degeneration and retinitis pigmentosa, and developing therapies.
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Karen Wai, MD
Clinical Assistant Professor, Ophthalmology
BioDr. Wai is a board-certified ophthalmologist and fellowship-trained vitreoretinal surgeon with Stanford Health Care Byers Eye Institute. She is also a clinical assistant professor of ophthalmology in the Department of Ophthalmology at Stanford University School of Medicine.
Dr. Wai is a retina specialist who diagnoses and treats retinal and macular diseases, including age-related macular degeneration, diabetic retinopathy, retinal vascular occlusions (blockages), and retinal tears/detachments. The retina is a tissue layer in the back of the eye. It converts light into signals that the brain then interprets as images. The macula is the part of the retina responsible for central (straight ahead) vision. Diseases of the retina and macula can cause low vision and vision loss.
Dr. Wai’s research interests include working with data from electronic health record databases to improve patient outcomes. She has researched morbidity and mortality (illness and death) rates in patients with retinal vein occlusions and retinal artery occlusions. A retinal vein occlusion is a blocked vein to the retina that can cause vision loss. A retinal artery occlusion is when an artery to the retina is blocked, which is also sometimes referred to as eye stroke. Dr. Wai has also examined the effects of systemic medications on the retina. She has won several ophthalmology awards, including the Heed Fellowship and Harvard Medical School’s Excellence in Clinical Instruction Resident Award.
Dr. Wai has published in more than 40 peer-reviewed journals, including Ophthalmology, American Journal of Ophthalmology, and JAMA Ophthalmology. She has presented research at meetings and conferences around the United States.
Dr. Wai is a member of the American Board of Ophthalmology. -
Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and of Education
Current Research and Scholarly InterestsModels and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes. Image systems simulations of optics and sensors and image processing. Data and computation management for reproducible research.
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Sophia Y. Wang, MD, MS
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsI use and integrate a wide variety of data sources in my research, spanning both structured and unstructured forms, including national survey datasets, health insurance claims data, patient generated online text, surgical video, and electronic health records. I investigate outcomes of treatments for glaucoma and cataract, as well as other areas of ophthalmology. My focus is on developing artificial intelligence methods to predict ophthalmology outcomes, while ensuring fairness.
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Sui Wang, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsOur research focuses on unraveling the molecular mechanisms underlying retinal development and diseases. We employ genetic and genomic tools to explore how various retinal cell types, including neurons, glia, and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels. In addition, we investigate their interactions and collective contributions to maintain retinal integrity.
1. Investigating retinal development:
We utilize genetic tools and methods such as in vivo plasmid electroporation and CRISPR to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal development.
2. Understanding diabetes-induced cell-type-specific responses in the retina:
Diabetes triggers a range of multicellular responses in the retina, such as vascular lesions, glial dysfunction, and neurodegeneration, all of which contribute to retinopathy. We delve into the detailed molecular mechanisms underlying these diabetes-induced cell-type-specific responses and the pathogenesis of diabetic retinopathy.
3. Developing molecular tools for labeling and manipulation of specific cell types in vivo:
Cis-regulatory elements, particularly enhancers, play pivotal roles in directing tissue- and cell-type-specific expression. Our interest lies in identifying enhancers that can drive cell type-specific expression in the retina and brain. We incorporate these enhancers into plasmid or AAV-based delivery systems, enabling precise labeling and manipulation of specific cell types in vivo.
