Stanford University
Showing 1,361-1,380 of 7,811 Results
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Steven M. Corsello
Assistant Professor of Medicine (Oncology)
Current Research and Scholarly InterestsOur laboratory operates at the intersection of functional genomics and chemical biology, with the goal of advancing novel molecular mechanisms of cancer inhibition to clinical use. We aim to 1) leverage phenotypic screening and functional genomics to determine novel anti-cancer mechanisms of small molecules, 2) develop new targeted therapy approaches against solid tumors, and 3) build a comprehensive community resource for drug repurposing discovery.
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Ximena Corso Díaz
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in unraveling the roles of RNA-binding proteins (RBPs) and regulatory RNAs in retinal development and homeostasis.
RNA-binding proteins mediate functional integration of transcriptional and post-transcriptional machineries influencing various aspects of gene expression and RNA metabolism. Several RBPs have cell-type enriched expression patterns in the retina or cause blinding diseases, however their role in retinal development and function is poorly understood. We have identified several RBPs that interact with the photoreceptor-specific transcription factor NRL and are likely involved in development and homeostasis of this retinal cell-type. We are pursuing the following lines of research:
1) RBPs in retinal development and degeneration. We will study the role of RBPs in regulating retinal development and maintaining homeostasis. We will focus on RBPs enriched in the retina, their interactions with retinal transcription factors like NRL, and their relevance to retinal diseases.
2) RBPs in R-loop regulation in the retina. R-loops are triple-stranded structures created when RNA anneals to one of the strands of the DNA duplex. R-loops have many regulatory roles during gene expression and their dysregulation can be detrimental to genome integrity. We observed that R-loops are dynamic during retinal development and identified key R-loop-associated RBPs that are enriched in rod photoreceptors and that interact with the transcription factor NRL. We will study the role of R-loops and their regulatory RBPs in retinal development and homeostasis.
3) Chromatin-associated regulatory RNAs through the retina lifespan. Chromatin-associated RNAs contribute to the dynamic regulation of gene expression, chromatin structure, and genome organization, playing essential roles in various biological processes, including development, differentiation, and disease. We will study how regulatory RNAs, together with their cognate RBPs, influence expression programs and chromatin dynamics through the retina lifespan. -
Victoria Cosgrove
Assistant Professor of Psychiatry and Behavioral Sciences (Child and Adolescent Psychiatry and Child Development)
Current Research and Scholarly InterestsDr. Cosgrove studies putative roles for life and family stress as well as inflammatory and neurotrophic pathways in the etiology and development of mood disorders across the life span.
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Helio Costa
Affiliate, Biomedical Informatics (BMI) graduate training program
BioHelio Costa, PhD, is a medical geneticist specializing in oncology, genomics, computational biology, data science, artificial intelligence, and product development. His work focuses on developing new cancer therapies and medical software to improve cancer patient care. He currently serves as Senior Medical Director and Head of Molecular Therapeutics & Drug Development at Natera and is an Adjunct Clinical Assistant Professor in the Department of Pathology at Stanford Medical School.
Dr. Costa’s research spans the entire drug development pipeline, from discovery to FDA-approved therapies. He leads efforts in developing innovative cancer treatments by integrating advanced genomics, computational biology, and AI-driven methodologies. His team focuses on the creation of targeted molecular therapeutics, using large-scale genetic data to identify novel treatment pathways and predict patient responses. In addition to drug discovery, Dr. Costa oversees the clinical trials necessary for validating these therapies, ensuring they meet rigorous standards for safety and efficacy. Furthermore, he manages the product development and commercialization process, guiding new treatments from initial research through to market-ready, FDA-approved cancer therapies.
In addition to his therapeutic work, Dr. Costa has led the development and implementation of genetic diagnostic tests and clinical algorithms used to support therapeutic decisions at Stanford Health Care. His contributions include the creation of DNA and RNA cancer diagnostic tests, as well as algorithms that analyze large-scale laboratory datasets and electronic medical records to predict patient outcomes. As a co-investigator with the NIH Clinical Genome Resource (ClinGen) Consortium, Dr. Costa oversaw developing FDA-recognized medical software used by healthcare providers, researchers, and biotech companies to assess the clinical relevance of genes and mutations.
He is the founding director of the Stanford Clinical Data Science Fellowship, where post-doctoral medical fellows engage in interdisciplinary clinical research and implement real-world health data solutions within Stanford Health Care. Dr. Costa is also an Attending Medical Geneticist for the Molecular Genetic Pathology Laboratory at Stanford Health Care, where he previously served as Assistant Lab Director.
Dr. Costa holds a BS in Genetics from the University of California, Davis, a PhD in Genetics from Stanford University School of Medicine, and completed his ABMGG Clinical Molecular Genetics and Genomics fellowship training at Stanford University School of Medicine. -
Ioanida Costache
Assistant Professor of Music
BioIoanida Costache is an assistant professor of ethnomusicology, and, by courtesy, Anthropology, at Stanford University. She is also an affiliate of the Center for Comparative Studies in Race and Ethnicity.
Her work explores the legacies of Romani historical trauma, and the feminist critiques of the present, inscribed in Romani music, sound, and art. Her writing has been published in EuropeNow, RevistaARTA, Critical Romani Studies, and is forthcoming in European History Quarterly. Her research has been supported by two Fulbright Grants and the Council of European Studies. She has held visiting and postdoctoral fellowships at the University of Pennsylvania, the United States Holocaust Memorial Museum, and the USC Shoah Foundation.
Her book project, Hearing Romani-ness, examines how music structures the political and social belonging of Romani peoples in ways that reify and work against processes of identity formation and racialization. Through an ethnographic focus on Romani musicians, the project shows how intergenerational memory of Romani trauma is discreetly imbedded in sonic expressions of sorrow within a bounded repertoire that in being kept private served as a vehicle for Romani collective healing. The book puts forth a new framework for navigating how sound, when heard as affective expression, can be used for reparative purposes in the wake of persecution, while also offering an interpretive and analytic vocabulary for learning to listen for the Roma. -
Christopher Costanza
Senior Lecturer of Music
BioFor over three decades cellist Christopher Costanza has enjoyed a varied and exciting career as a soloist, chamber musician, and teacher. A winner of the Young Concert Artists International Auditions and a recipient of a prestigious Solo Recitalists Grant from the National Endowment for the Arts, Mr. Costanza has performed to wide critical acclaim in nearly every state in the U.S., and in Canada, Colombia, the Dominican Republic, Australia, New Zealand, China, Korea, Germany, France, the U.K., Italy, Spain, the Netherlands, Belgium, Luxembourg, Romania, and Hungary. His summer festival appearances include the Marlboro, Yellow Barn, Santa Fe, Taos, Chamber Music Northwest, Seattle, Bay Chamber Concerts, Ottawa, and Bravo! Vail Valley festivals. Mr. Costanza is a graduate of the New England Conservatory of Music in Boston, where he studied cello with Laurence Lesser, David Wells, and Bernard Greenhouse, and chamber music with Eugene Lehner, Louis Krasner, and Leonard Shure.
Mr. Costanza joined the St. Lawrence String Quartet (SLSQ) in 2003, and tours and records extensively with that ensemble, performing over 100 concerts annually throughout the world. As a member of the SLSQ, he is an Artist in Residence at Stanford University, where he teaches cello and chamber music and performs a wide variety of formal and informal concerts each season, from the stages of the University’s concert halls to student dormitories and lecture halls. A strong proponent of contemporary music, Mr. Costanza works regularly with the world’s most notable composers, such as John Adams, Jonathan Berger, Osvaldo Golijov, Mark Applebaum, Pierre Boulez, George Tsontakis, Roberto Sierra, R. Murray Schafer, William Bolcom, John Corigliano, and Bright Sheng. As a student, he had the honor of studying Olivier Messiaen’s “Quartet for the End of Time” under the guidance of the composer.
Mr. Costanza’s discography includes numerous chamber music and solo recordings on the Nonesuch, EMI/Angel, Naxos, Innova, Albany, Summit, and ArtistShare labels. In 2006, he received a Grammy nomination for his recording of major chamber works for winds and strings by Mozart. Additionally, several St. Lawrence String Quartet recordings on EMI have also been nominated for Juno awards. Mr. Costanza's recordings of the iconic Six Suites for Solo Cello by J.S. Bach, along with his commentary on each suite, can be found on his website, costanzacello.com. In August, 2019, the SLSQ released its latest recording, of all six Op. 20 String Quartets of Haydn, in three formats: CD’s, on-line through streaming platforms, and limited-edition vinyl LP’s.
Mr. Costanza is frequently heard on radio broadcasts worldwide, including the CBC in Canada, NPR in the United States, and on various European broadcasting networks. He is privileged to perform on an early 18th century Venetian cello, part of the Harry R. Lange Collection of Instruments and Bows at Stanford.
In addition to his varied musical interests, Mr. Costanza is an avid long-distance runner and hiker. A self-described train enthusiast, he enjoys riding and exploring the passenger railways of the world. He is fascinated by architecture and seeks out innovative architectural offerings of each city he visits on tour. At home in California, he is passionate about cooking, focusing his attention on new and creative dishes which take advantage of the abundance of remarkable organic local produce. Mr. Costanza's wife, Debra Fong, is a wonderful violinist, and their daughter, Isabella, is a terrific violist currently studying at the Glenn Gould School in Toronto. -
Lauren Cote
Basic Life Res Scientist
Postdoctoral Scholar, BiologyBioI'm a developmental biologist with a background in planarian regeneration who is studying epithelial cells in Jessica Feldman's lab as a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation. I'm interested in understanding better how different kinds of epithelial cells, like the cells that line your gut and the cells that make up your skin, are able to correctly connect to one another and form fully continuous organs.
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Richard Cottle
Professor of Management Science and Engineering, Emeritus
BioRichard W. (Dick) Cottle was born in Chicago in 1934. He received his elementary and high school education in the neighboring village of Oak Park. Dick enrolled at Harvard College to take up political science and premedical studies in order to become a physician (or possibly a foreign service officer if that didn't work out). As it happened, both of these alternatives were abandoned because he was strongly attracted to mathematics and ultimately received his bachelor's degree in that field. He stayed on at Harvard and received the master's degree in mathematics in 1958. This was the Sputnik era, and Dick was moved by a passion to teach secondary-level mathematics. In the first of a series of fateful decisions, he joined the Mathematics Department at the Middlesex School in Concord, Massachusetts where for two years he taught grades 7-12. Midway through this period he married his wife Suzanne (Sue). At this time he began to think of returning to graduate school for a doctorate in mathematics. He decided to study geometry at the University of California at Berkeley and was admitted there. Just before leaving Middlesex, Dick received a telephone call from the Radiation Laboratory at Berkeley offering him the part- time job as a computer programmer for which he had applied. Through this job, he became aware of linear and quadratic programming and the contributions of George Dantzig and Philip Wolfe. Before long, Dick left the Rad Lab to join Dantzig's team at the Operations Research Center at UC Berkeley. Under the tutelage of George Dantzig (and the late Edmund Eisenberg), Dick developed a symmetric duality theory and what was then called the "composite problem". These topics along with a reëxamination of the Fritz John conditions, formed the core of his doctoral dissertation. The composite problem involved a fusion of the primal and dual first-order optimality conditions. It was realized that the resulting inequality system could be studied without reference to the primal-dual structure out of which it was born. The name "complementarity problem" was suggested by Dick and introduced in a joint paper with Habetler and Lemke. After Berkeley, Dick's work took two closely related directions. One was the study of quadratic programming; the other was what we now call "linear complementarity". The interesting role played by classes of matrices in both these areas has always held a special fascination for Dick. In quadratic programming, for instance, with Jacques Ferland he obtained characterizations of quasi- and pseudo-convexity of quadratic functions. Dick (and others) were quick to recognize the importance of matrix classes in linear complementarity theory. It was he who proposed the name "copositive-plus" for a matrix class that arose in Lemke's seminal paper of 1965. The name first appeared in the classic paper of Cottle and Dantzig called "Complementary Pivot Theory of Mathematical Programming". The subjects of quadratic programming and linear complementarity (and the associated matrix theory) remain central to his research interests.
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Alexandra Cours, MD
Clinical Assistant Professor, Medicine - Primary Care and Population Health
BioDr. Cours is a clinician educator in Geriatric Medicine at Stanford University, providing primary care for older adults and serving as a geriatric medicine consultant at Stanford Hospital. As Medical Director of the Acute Care for Elders (ACE) Unit, she leads specialized care for hospitalized older adults to optimize outcomes. She is also the Geriatric Section Director for Age-Friendly Health Systems, leading clinical and strategic efforts to advance age-friendly, evidence-based care across hospital settings and overseeing quality-improvement initiatives, including a delirium-reduction program. Dr. Cours leads a personal and professional development program for geriatrics fellows that prepares them for the transition to independent practice. In addition, she participates in the Foundations of Academic Clinical Excellence and Transformation (FACET) Faculty Development Fellowship and the Clinician Educator Scholars (CE Scholars) Program, which develop clinician expertise in ecosystem awareness, quality improvement, education, and clinical informatics through mentored initiatives that culminate in publishable work and career growth.
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Jesse Courtier
Adjunct Clinical Professor, Radiology - Pediatric Radiology
BioPrior to joining Stanford and Lucille Packard Children's Hospital, Dr. Jesse Courtier was Professor and Chief of Pediatric Radiology at UCSF Benioff Children’s Hospital, San Francisco. He is the author of over 70 peer reviewed articles with more than 3000+ citations. Dr. Courtier is a multi-award-winning educator and innovator. He is also an entrepreneur, startup mentor, and healthcare investor.
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Markus Covert
Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.
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Robert P. Cowan, MD, FAAN, FAHS
Clinical Professor, Adult Neurology
Clinical Professor (By courtesy), Anesthesiology, Perioperative and Pain MedicineCurrent Research and Scholarly InterestsCurrent interest focus on patient education technology and patient/physician communication with a particular emphasis on tools which increase encounter efficiency and improve outcomes. Basic research focuses on mechanisms of action in Chronic Daily Headache, with a particular emphasis on New Daily Persistent Headache. Techniques include fMRI, biomarker investigation and evoked potentials. Clinical research includes clinical trials of novel treatments for episodic and chronic headache forms.
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Tina Cowan
Professor of Pathology (Clinical) and, by courtesy, of Pediatrics (Genetics)
Current Research and Scholarly Interestsscreening and diagnosis of patients with inborn errors of metabolism, including newborn screening, development of new testing methods and genotype/phenotype correlations.
