Stanford University
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Christopher A. Azaldegui
Postdoctoral Scholar, Photon Science, SLAC
Postdoctoral Scholar, Structural BiologyCurrent Research and Scholarly InterestsI develop correlative light and electron microscopy approaches to study microbes. Among these are the implementation of fluorescent biosensors in cryogenic electron tomography workflows to provide physiological context to the cellular ultrastructures observed. In another front, I am developing a novel CLEM approach to visualize lipids in pathogenic bacteria.
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Christopher O. Barnes
Assistant Professor of Biology and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsResearch in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. We combine biophysical and structural methods (e.g., cryo-EM), protein engineering, and in vivo approaches to understand how enveloped viruses infect host cells and elicit antigen-specific immune responses. We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats.
HIV-1; SARS-CoV-2; coronaviruses; cryo-EM; crystallography; vaccines; directed evolution
