Stanford University
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Chad S. Weldy, M.D., Ph.D.
Instructor, Medicine - Cardiovascular Medicine
Current Research and Scholarly InterestsAs a physician-scientist I work to understand the genetic basis of cardiovascular disease and the transcriptional and epigenomic mechanisms of atherosclerosis. My work is focused across four main areas of cardiovascular genetics and mechanisms of coronary artery disease and smooth muscle biology:
1.Vascular smooth muscle specific ADAR1 mediated RNA editing of double stranded RNA and activation of the double stranded RNA receptor MDA5 in coronary artery disease and vascular calcification
2.Defining on single cell resolution the cellular and epigenomic features of human vascular disease across vascular beds of differing embryonic origin
3.CRISPRi screening with targeted perturb seq (TAPseq) to identify novel CAD genes in human coronary artery smooth muscle cells
4.Investigation of the epigenetic and molecular basis of coronary artery disease and smooth muscle cell transition in mice with conditional smooth muscle genetic deletion of CAD genes Pdgfd and Sox9
My work is focused on discovery of causal mechanisms of disease through leveraging human genetics with sophisticated molecular biology, single cell sequencing technologies, and mouse models of disease. This work attempts to apply multiple scientific research arms to ultimately lead to novel understandings of vascular disease and discover important new therapeutic approaches for drug discovery.
First Author Manuscripts for this work:
•Weldy, C. S., et al. (2025). Smooth muscle cell expression of RNA editing enzyme ADAR1 controls activation of RNA sensor MDA5 in atherosclerosis. (2025). Nature Cardiovascular Research. 1-17, PMID: 40958051, doi: 10.1038/s44161-025-00710-5
•*Selected as finalist for Louis N. and Arnold M. Katz Basic Science Research Prize from the American Heart Association, finalist competition November 16, 2024, Chicago
•Work was highlighted in the Stanford Department of Medicine News
https://medicine.stanford.edu/news/current-news/standard-news/RNA-editing.html
•Weldy, C.S., et al. (2025). Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci. Molecular Systems Biology. 1-25, PMID: 40931195, doi:10.1038/s44320-025-00140-2.
•*Selected for the cover of November 2025 edition of Molecular Systems Biology
Grant funding received for this work:
Mentored Clinical Scientist Research Career Development Award (K08)(NIH/NHLBI, 1 K08 HL167699-01), August, 2023 – July 2028. PI: Weldy, Chad
•Title of proposal: “ADAR Mediated RNA editing is a causal mechanism in coronary artery disease”.
•Activated 08/01/2023
•$850,000 over 5 years
Career Development Award, American Heart Association (AHA CDA)(23CDA1042900), July, 2023 – June, 2026. PI: Weldy, Chad
•Title of proposal: “Linking RNA editing to coronary artery calcification and disease”
•Activated 07/01/2023
•$231,000 over three years
NIH Loan Repayment Program (LRP) Award (NIH/NHLBI) Renewal Award, July, 2023. PI: Weldy, Chad
•Title of proposal: “RNA editing is a causal mechanism of coronary artery disease”
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) (NIH/NHLBI, 1 F32 HL160067-01), July, 2021 – June 2023 (Completed). PI: Weldy, Chad
• Titled, “A transcriptional network which governs smooth muscle transition is mediated by causal coronary artery disease gene PDGFD”
•*Received perfect score with impact score 10, 1st percentile
NIH Loan Repayment Program (LRP) Award (NIH/NHLBI), July, 2021. PI: Weldy, Chad
•Title of proposal: "Single cell transcriptomic and epigenomic features of human atherosclerosis".
•This will award up to $100,000 towards student loans over the next 24 months with opportunity for renewal after 24 months. -
Kevin Wells
Adm Svcs Admstr 2, Physics
Current Role at StanfordExecutive Director, Stanford Institute for Theoretical Physics
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Andy Wen
Clinical Professor, Pediatrics - Critical Care
BioDr. Andy Y. Wen joined the Division of Pediatric Critical Care Medicine at Stanford University School of Medicine in 2019. He received his B.A. degree in Molecular Biology & Biochemistry at Rutgers University, and his medical degree from Rutgers Robert Wood Johnson Medical School. He completed a Pediatrics Residency Training Program at the State University of New York Downstate Medical Center and a Pediatric Critical Care Medicine Fellowship Training Program at the University of California Los Angeles.
After briefly working for Kaiser Permanente Southern California Permanente Medical Group, Dr. Wen joined the Division of Pediatric Critical Care at NYU School of Medicine. He assumed the role of Bellevue Hospital PICU medical director and helped to expand Bellevue's Pediatric Trauma Program and Pediatric Critical Care Transport Services for the New York City (NYC) public hospital system, NYC Health & Hospitals. During the 2014 to 2016 Ebola outbreak in West Africa, Dr. Wen was a member of the Special Pathogens Program at Bellevue Hospital, which was one of only four institutions in the US to treat a patient with Ebola and helped established the National Ebola Training and Education Center (NETEC).
While at UCLA, Dr. Wen received a T32 Training Grant to perform research investigating the role of transcription factor CREB in innate immune function using a murine model for AML. At NYU, his research projects included analyzing transfusion practices in the PICU, quality improvement projects targeting patients at high risk for unplanned extubation, and exploring the utility of NIRS as an early predictor of seizure activity. Dr. Wen is a member of Pediatric Acute Lung Injury & Sepsis Investigators (PALISI) and has been involved in multi-center studies looking at critical care patients with Bronchiolitis and COVID-19. Dr. Wen is the USA Editor for Journal of Pediatric Intensive Care and has reviewed abstracts for PAS, SCCM, and AMIA. His educational efforts have included teaching Pediatric Fundamental Critical Care Support (PFCCS) courses, helping develop a Pediatric Residency Simulation course curriculum, and helping develop a Point-of-Care Ultrasound course for critical care advanced practice providers.
At Stanford University School of Medicine, Dr. Wen is in charge of Regional Pediatric Critical Care Outreach with a goal to promote medical education and expand the Stanford Children’s Health network to improve access for sick children in need of high quality care. Dr. Wen provides clinical services at both John Muir Medical Center and Lucile Packard Children’s Hospital. -
Gerald Wen
IT Manager, Anesthesiology, Perioperative and Pain Medicine
Current Role at StanfordIT Manager
Tuesday/Thursday @ Redwood City Campus, Discovery Hall
