Stanford University
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Maria Barna
Associate Professor of Genetics
Current Research and Scholarly InterestsThe Barna Lab studies how gene expression is controlled at the level of translation to shape development, regeneration, and disease.For decades, ribosomes were viewed as uniform molecular machines that passively translate genetic information. Our work helped overturn this paradigm by demonstrating that ribosomes can differ in composition and function, giving rise to specialized translation programs that regulate cell fate and organismal development. By integrating genomics, mass spectrometry,
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Christopher O. Barnes
Assistant Professor of Biology and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsResearch in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. We combine biophysical and structural methods (e.g., cryo-EM), protein engineering, and in vivo approaches to understand how enveloped viruses infect host cells and elicit antigen-specific immune responses. We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats.
HIV-1; SARS-CoV-2; coronaviruses; cryo-EM; crystallography; vaccines; directed evolution
