Stanford University
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Taia T. Wang, MD, PhD, MSCI
Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsLaboratory of Mechanisms in Human Immunity and Disease Pathogenesis
Antibodies are a critical component of host defense. While the importance of humoral immunity has been recognized for decades, substantial gaps in knowledge remain around how antibodies function, and how their function is regulated, in vivo. Our laboratory performs studies designed to fill in these gaps, with the goal of enabling new vaccine and therapeutic strategies to prevent human disease. My interest in this area culminated from training in medicine, RNA virus biology (PhD), and molecular antibody biology (postdoctoral training). The intersection of these topics, viral immunity and disease pathogenesis, is the focus of our work. The essential question driving our research is why a small subset of people develop severe or fatal disease during viral infection while most infections result in a subclinical or mild outcome, even in at-risk populations. Our hypothesis is that the antibody signaling pathways that are engaged during viral infection through Fc gamma receptors (FcγRs) are a key driver of these distinct outcomes. We are focused on several major unknowns to address this hypothesis: How are antibody effector functions regulated in vivo and does this change in disease? How do distinct signaling pathways engaged by IgG immune complex-FcγR interactions impact host cell genetic regulation and the ultimate inflammatory/immune response? What are the tissue-specific functions that antibodies engage? How does the heterogeneity in post-translational modifications (PTMs) of human antibodies contribute to heterogeneity in viral immunity?
Current clinical studies:
Recruiting:
An Open Label Study of IgG Fc Glycan Composition in Human Immunity
Principal Investigator: Taia T. Wang, MD, PhD
ClinicalTrials.gov Identifier:
NCT01967238 -
Katherine T. Ward, MD
Clinical Professor, Medicine - Primary Care and Population Health
BioDr. Ward is a board-certified, fellowship-trained geriatrician with Stanford Senior Care in Palo Alto, California. She is also board certified in hospice and palliative medicine and internal medicine. Dr. Ward is a clinical professor of medicine and clinical chief of the Geriatrics Section in the Department of Medicine, Division of Primary Care and Population Health at Stanford University School of Medicine.
She specializes in many facets of care for older adults, including internal medicine, dementia care, and palliative care. Dr. Ward uses her extensive experience to teach and implement best practices in nursing home care, geriatric assessment, and care transitions for older adults.
Dr. Ward’s research interests include early detection of dementia in vulnerable populations, dementia care support programs, and geriatric assessment in diverse populations.
She has published her research in peer-reviewed journals including The American Journal of Geriatric Pharmacotherapy; The Journal of Nutrition, Health & Aging; and the Journal of Palliative Medicine. She has served as an ad hoc reviewer for several journals, including Geriatrics. She has also presented posters at annual meetings of the American Geriatrics Society and the Society of General Internal Medicine.
Dr. Ward is a member of the American College of Physicians and the American Geriatrics Society. -
Brian Wayda
Postdoctoral Scholar, Cardiovascular Medicine
Current Research and Scholarly InterestsHeart transplant policy and outcomes, cost-effectiveness, mathematical modeling
