Stanford University
Showing 81-100 of 139 Results
-
Eric Meffre
Professor of Medicine (Immunology and Rheumatology)
BioDr. Meffre obtained his PhD in Immunology from the Université d’Aix-Marseille in France before he moved to the USA as a postdoc fellow in the laboratory of Dr. Michel Nussenzweig at The Rockefeller University in New York City. He became an assistant professor at Cornell University in 2003 before being recruited at Yale University as associate professor in 2009. He was tenured at Yale in 2014 before he joined the Department of Medicine/Division of Immunology and Rheumatology at Stanford University as a tenured full professor in 2022.
Dr. Meffre’s work focuses on the etiology of autoimmune syndromes and the roles played by B cells in these diseases. His group characterized the abnormal selection of developing autoreactive B cells in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), multiple sclerosis (MS) and Sjögren’s syndrome, resulting in large numbers of autoreactive naïve B cells accumulating in the patient’s blood. Hence, these autoreactive B cells may present self-antigens to T cells and initiate autoimmune diseases. These early B cell tolerance defects are likely primary to these autoimmune diseases and may result from genetic factors such as the 1858T PTPN22 allele that segregates with RA, SLE and T1D and correlate with an impaired removal of developing autoreactive B cells.
His research goals also consist in characterizing the molecules and pathways involved in the establishment of B cell tolerance and the removal of developing autoreactive B cells generated by random V(D)J recombination through the investigation of rare patients with primary immunodeficiency (PID) enrolled through an international network. Alteration of B cell receptor (BCR) or Toll-like receptor (TLR) signaling in PID patients results in a defective central B cell tolerance and a failure to counterselect developing autoreactive B cells in the bone marrow. In contrast, functional and suppressive regulatory T cells play a key role in preventing the accumulation of autoreactive clones in the mature naïve B cell compartment. The recent development of humanized mouse models recapitulating early B cell tolerance checkpoints and their defects in autoimmune settings allow further in-depth investigation of tolerance mechanisms and the development of novel approaches to restore defective central and peripheral B cell tolerance checkpoints and thwart autoimmunity. -
Elizabeth Mellins
Member, Bio-X
Current Research and Scholarly InterestsMolecular mechanisms and intracellular pathways of MHC class II antigen processing and presentation, with a focus on B cells; mechanisms underlying HLA allele association with disease; disease mechanisms in systemic juvenile idiopathic arthritis, including an HLA-linked complication; monocytes as drivers or suppressors of auto-inflammation in systemic juvenile idiopathic arthritis and pediatric acute neuropsychiatric syndrome.
-
Maneesh Kumar Misra
Clinical Associate Professor, Pathology
Current Research and Scholarly InterestsMy research goal is to utilize the cutting edge of stat of art histocompatibility testing to better understand the humoral and cellular responses in clinical transplantation, and to translate this knowledge into improved treatment, and transplant outcome.
-
Daria Mochly-Rosen
George D. Smith Professor of Translational Medicine
Current Research and Scholarly InterestsTwo areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases.
-
Stephen B. Montgomery
Stanford Medicine Professor of Pathology, Professor of Genetics and of Biomedical Data Science and, by courtesy, of Computer Science
Current Research and Scholarly InterestsWe focus on understanding the effects of genome variation on cellular phenotypes and cellular modeling of disease through genomic approaches such as next generation RNA sequencing in combination with developing and utilizing state-of-the-art bioinformatics and statistical genetics approaches. See our website at http://montgomerylab.stanford.edu/
-
Shweta S. Namjoshi MD MPH
Clinical Associate Professor, Pediatrics - Gastroenterology
Current Research and Scholarly Interests1. The mission of the International Intestinal Failure Registry (IIFR) is to provide the international intestinal rehabilitation and transplant community with accurate data on the outcomes and course of intestinal failure to support research, quality improvement, and policy development. https://tts.org/irta-registries/irta-ifr
2. NCT05241444 is the first-in-human, Phase 1 clinical trial will test the feasibility of the manufacturing and the safety of the administration of CD4^LVFOXP3 in up to 36 evaluable human participants with IPEX and evaluate the impact of the CD4^LVFOXP3 infusion on the disease.
3. Stanford's local Intestinal Failure Registry (SIFR) ensures ongoing assessment and improvement of intestinal failure outcomes and care provided at Stanford in collaboratiton with the Division of Pediatric Surgery. This registry focuses on clinical outcomes and social developmental outcomes for patients with short bowel syndrome, pediatric CODEs, and pseudoobstruction. -
Amrita Narang
Clinical Associate Professor, Pediatrics - Gastroenterology
BioMy clinical and research interests are in neonatal cholestatic liver diseases, including biliary atresia and fatty liver disease. I'm also highly experienced in liver transplant care, with a particular focus on teen and transition of care.
In addition to my clinical and research work, I'm deeply committed to medical education and patient education. I believe that knowledge is power, and I strive to empower my patients and their families with the resources and information they need to make informed decisions about their care.
As a physician, I'm dedicated to providing the highest level of care to my patients and their families. I believe that every child deserves the best possible chance at a healthy and fulfilling life, and I'm honored to play a role in helping them achieve that goal. -
Derick Okwan
Assistant Professor of Pathology
Current Research and Scholarly InterestsBroadly, the Okwan lab’s primary interest is to understand how and why the immune system contributes to nearly all chronic diseases. The immune system of the modern human has evolved from a history of stress to the species: famines, continual bouts of lethal pandemics, as well as major climate/environmental and migratory changes that exposed the immune system to novel threats. At the forefront of these challenges are innate immune cells, particularly neutrophils, the most abundant leukocytes. For the first time in human history – at least in the western world- we live in an era of abundance. The Okwan lab is interested in understanding how this traumatic history creates a functional mismatch for the neutrophil, which we believe underpins their roles in chronic diseases of the modern era: cancer, cardiovascular disease, neurodegeneration, and autoimmune disorders. Rather than wholesale depletion of neutrophils and innate immune cells, we seek to identify novel approaches to leverage these cells to combat various diseases.
-
Meeta Raman Patel
Adjunct Clinical Assistant Professor, Pediatrics - Gastroenterology
BioDr. Patel has been working with children with autism and other disabilities for over 20 years. She is a Board Certified Behavior Analyst. Dr. Patel received a BS degree from the University of California at Davis in 1996 in Psychology with an emphasis in Biology. She continued her graduate training in Psychology at the University of Nevada, Reno. Dr. Patel received her PhD in Psychology with an emphasis in Behavior Analysis.
She completed a post-doctoral fellowship at the Kennedy Krieger Institute and Johns Hopkins University School of Medicine in 2001. Dr. Patel joined the faculty at the Marcus and Kennedy Krieger Institutes in 2001 and Emory University School of Medicine in 2002. Dr. Patel was a case manager in the Pediatric Feeding Disorders and Early Intervention Programs at the Marcus and Kennedy Krieger Institutes from 2001-2003. In 2003, she started Clinic 4 Kidz, which is a home-based Interdisciplinary Pediatric Feeding Disorders Program. Currently, she serves as the Executive Director of Clinic 4 Kidz.
Her research and clinical interests focus on treating feeding problems in children who have underlying medical issues (e.g., prematurity, failure to thrive [FTT], tube dependence, gastroesophageal reflux [GER], food allergies, etc.). In addition, she has expertise in working with children with autism, more specifically treating food selectivity by type and/or texture.
She currently serves on the editorial board of Behavioral Development which is a journal of the American Psychological Association. She formerly served on the editorial boards for the Journal of Applied Behavior Analysis and Education and Treatment of Children. Dr. Patel also serves as a guest reviewer for several journals. She has published over 20 research studies in peer-reviewed journals and has authored two invited book chapters. Dr. Patel has also been invited to present at numerous conferences and at various hospitals all over the country.
