Stanford University
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Patrick Lee Purdon
Professor of Anesthesiology, Perioperative and Pain Medicine (Department Research) and, by courtesy, of Bioengineering
BioMy research integrates neuroimaging, biomedical signal processing, and the systems neuroscience of general anesthesia and sedation.
My group conducts human studies of anesthesia-induced unconsciousness, using a variety of techniques including multimodal neuroimaging, high-density EEG, and invasive neurophysiological recordings used to diagnose medically refractory epilepsy. We also develop novel methods in neuroimaging and biomedical signal processing to support these studies, as well as methods for monitoring level of consciousness under general anesthesia using EEG. -
Renee P Pyle, Ph.D.
Adjunct Clinical Assistant Professor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
BioDr. Pyle is a child psychologist who has worked in clinic, hospital, school, and private practice settings for over 20 years. She is also an Adjunct Clinical Assistant Professor in the Stanford University Department of Psychiatry and Behavioral Sciences where she supervises and teaches the child and adolescent psychiatry fellows. She received her B.A. in Human Biology from Stanford University and her Ph.D. from the University of California, Santa Barbara.
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Abdullah Qatu, MD
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
BioDr. Qatu is a board-certified, fellowship-trained pain management specialist at the Stanford Health Care Pain Management Center. He is also a clinical instructor in the Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pain Medicine, at Stanford University School of Medicine.
He specializes in the diagnosis and management of many different types of pain, including nerve pain, joint pain, cancer pain, low back and neck pain. Dr. Qatu obtained his medical degree from the New York University (NYU) Grossman School of Medicine. He continued on at NYU to complete his residency in anesthesiology after completing an internship in general surgery. He subsequently completed his pain medicine fellowship at Stanford University School of Medicine.
Dr. Qatu believes in utilizing a multimodal approach for pain management. This includes interventional, pharmacological, rehabilitative and psychological strategies. He is well-trained in a wide variety of interventional modalities that include injections, epidurals, nerve blocks, radiofrequency ablations, peripheral nerve stimulation, spinal cord/dorsal root ganglion stimulation and minimally invasive decompression. His research focuses on the clinical use of neuromodulation for various types of pain. In addition, he has investigated whether certain demographic and socioeconomic variables, as well as psychiatric illness, affect the outcomes of various orthopaedic traumas and surgeries. Dr. Qatu has presented his research at conferences throughout the U.S. and in Canada. -
Stanley Qi
Associate Professor of Bioengineering
BioStanley Qi (publishing as Lei S. Qi) is a pioneer in the field of genome engineering and the architect of the foundational technologies that transitioned CRISPR from a "cutting" tool into a universal platform for Programmable Biology. As the inventor of CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa), Qi established the first methods for the precise, reversible, and targeted regulation of the human genome without altering the DNA sequence.
The Qi Lab integrates scalable genomic perturbation with live-cell and super-resolution imaging and computation-guided design to redefine the boundaries of cellular control. Under Dr. Qi’s leadership, the group has fundamentally expanded the genome engineering toolbox, evolving CRISPR from a single editing tool into a multidimensional platform for the precise control of dynamic and spatial cell states. This work includes establishing foundational technologies and architectures for precise epigenetic editing, multiplexed regulation of the transcriptome, programmable 3D genome organization, and spatial control of RNA logistics. By pioneering real-time visualization of chromatin dynamics and RNA in living cells, the lab provides an unprecedented window into the fundamental "control principles of life."
This principle-driven technology lineage has moved into the clinic, with the lab's compact epigenetic editor currently in first-in-human clinical testing for FSHD muscular dystrophy (NCT06907875). This milestone represents a core mission of the lab: translating foundational engineering into next-generation therapeutics that act predictably as dynamic, complex systems.
Beyond single-cell control, the Qi Lab is building a framework for synthetic cell–cell communication, with a particular emphasis on the bidirectional interplay between immune cells and neurons. The lab’s goal is to move beyond describing molecular parts to discovering fundamental control principles in living systems: how regulatory landscapes create stable states and memory, how spatial genome–RNA organization shapes dynamic responses, and how engineered cell–cell interactions can generate emergent multicellular behaviors.
By integrating computational design with experimental biology, Dr. Qi aims to identify the generalizable rules linking molecular programs to systems-level physiology. He is a Chan Zuckerberg Biohub Investigator and an Institute Scholar at the Sarafan ChEM-H, and is dedicated to shaping the technical and ethical frameworks that will define the future of human genome engineering.
