Stanford University
Showing 1,141-1,160 of 2,473 Results
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Fredric Kraemer
Gerald M. Reaven, MD, Professor of Endocrinology, Emeritus
Current Research and Scholarly InterestsOur research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology.
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Sheri Krams
Senior Associate Dean, Graduate Education and Postdoctoral Affairs and Professor of Surgery (Abdominal Transplantation)
Current Research and Scholarly InterestsResearch Interests: 1) NK Cell Responses to EBV, 2) Exosomes in Immune Responses, 3) Plasmacytoid Dendritic Cell-Mediated Graft Prolongation, 4)Transplant Immunology
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Elliot J. Krane
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric Anesthesia) at the Stanford University Medical Center, Emeritus
Current Research and Scholarly InterestsThe management of pain in children using intraspinal opioids, regional anesthetics, and novel analgesic agents; cerebral and osmolar complications of diabetic ketoacidosis in children.
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Mark Krasnow
Paul and Mildred Berg Professor
Current Research and Scholarly Interests- Lung development and stem cells
- Neural circuits of breathing and speaking
- Lung diseases including lung cancer
- New genetic model organism for biology, behavior, health and conservation -
Emily Kraus
Clinical Assistant Professor, Orthopaedic Surgery
BioDr. Kraus is a Clinical Assistant Professor at Stanford Children’s Orthopedic and Sports Medicine Center trained in the specialty of Physical Medicine and Rehabilitation (PM&R) sports medicine. She has research and clinical interests in endurance sports medicine, injury prevention, running biomechanics, prevention of bone stress injuries, and the promotion of health and wellness at any age of life. Dr. Kraus is the director of the FASTR Program, which stands for Female Athlete Science and Translational Research. The FASTR program is supported by the Wu Tsai Human Performance Alliance and seeks to close the gender gap in sports science research with an emphasis on early identification and interventions to prevent injury and identify ways to optimize performance in female athletes. Dr. Kraus is also a member of the U.S. Olympic and Paralympic Committee Women's Health Task Force and is the medical director of the Stanford Children's Motion Analysis and Sport Performance Lab. She has completed nine marathons including the Boston Marathon twice and one 50k ultramarathon. With running and staying physically active as one of her personal passions, she recognizes the importance of fitness for overall wellbeing and the prevention of chronic medical conditions.
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Alan M. Krensky, M.D.
Shelagh Galligan Professor in the School of Medicine, Emeritus
Current Research and Scholarly InterestsMechanisms and therapies for infection, cancer, autoimmunity and transplantation.
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Siddharth Krishnan
Assistant Professor of Electrical Engineering, and by courtesy, of Bioengineering and of Materials Science and Engineering
Current Research and Scholarly InterestsThe Krishnan Lab develops bioelectronic devices, tools and systems for closed loop disease management. Our work is divided into the following broad areas:
1. Biohybrid electronics for therapy and sensing: we combine living cells as functional parts of implantable devices, leveraging their ability to produce complex biologic therapeutics in a constitutive or triggerable manner, and their ability to sense their complex dynamic environment. These efforts are focused on developed functional cures for diseases like Type I Diabetes and other conditions requiring the regular infusion of proteins, peptides or antibody drugs.
2. Digital drug release systems for particulate forms of biologic drugs: Many complex protein and peptide drugs are not stable in solution, thereby frustrating the ability to delivery them through pumps and autoinjectors. This need is particularly acute for drugs that need to be administered as emergency rescue therapies, such as glucagon in the context of type 1 Diabetes. We develop implantable, miniaturized microelectromechanical devices that can store particulate (powders, pills) forms of these drugs and release them in a close loop manner based on wireless inputs from sensors.
3. Wearable sensors: Wearables to detect biophysical (temperature, flow, cardiac activity) and biochemical markers of health are gaining importance for closed-loop disease management and personalized medicine. We design hardware for on-chip molecular profiling based on sampling biofluids in noninvasive or minimally invasive formats.
4. New wireless power architectures for implantable bioelectronics: We develop high-power, high-efficiency strongly coupled power harvesting system to power battery-free implant systems. -
George Krompacky
Publications Manager, FSI - S-APARC
Current Role at StanfordPublications Manager at the Walter H. Shorenstein Asia-Pacific Research Center
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Sharon Krossa
Affiliate, Geballe Laboratory for Advanced Materials
BioSharon blames (in chronological order) her parents, CS Lewis, Brother Alfred, Clan Colin & the original Renaissance Pleasure Faire North, HyperCard, Grant G. Simpson, Stanford, her therapist, Drupal, and her husband for where she is now. Note that her bio, honors and awards, and publications are bogus. (Well, the bio is real, but the rest are purely for testing purposes. It's her job, honest.)
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Thomas M. Krummel, MD, FACS/FAAP
Emile Holman Professor, Emeritus
Current Research and Scholarly InterestsSurgical Innovation, Simulation and Virtual Reality in Surgical Education, Fetal Healing-Cellular and Biochemical Mechanisms
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Joy Ku
Research Technical Manager, Wu Tsai Human Performance Alliance
Current Role at StanfordJoy Ku is focused on biocomputation and the advancement of their use through teaching, science communications, community building, and the promotion of research resource sharing efforts, particularly as related to reproducibility and open-source science.
She is currently Senior Director of the Wu Tsai Human Performance Alliance at Stanford (https://humanperformance.stanford.edu) and also leads the education and outreach efforts for the overall Wu Tsai Human Performance Alliance, which consists of institutions across the country, including Salk, UC San Diego, the University of Kansas, the University of Oregon, and the Women's Health, Sports & Performance Institute. The Alliance's mission is to discover biological principles to optimize human performance and catalyze innovations in human health.
Dr. Ku is also the Director of Promotions and Didactic Interactions for the NIH-funded Restore Center (https://restore.stanford.edu), as well as the Director of Education and Communications for the Mobilize Center (https://mobilize.stanford.edu), an NIH Biomedical Technology Resource Center. Both Centers provide tools, infrastructure, and training to support the research community. The Mobilize Center's emphasis is on biomechanical modeling and machine learning algorithms to provide new insights into human movement from data sources, such as wearables, video, and medical images. The Restore Center's mission is to advance rehabilitation research using mobile sensor and video technology for real-world assessments of movement and factors affecting movement.
She also manages SimTK (https://simtk.org), a software, model, and data-sharing platform for the biocomputation research community. -
Ellen Kuhl
Catherine Holman Johnson Director of Stanford Bio-X, Walter B Reinhold Professor in the School of Engineering, Professor of Mechanical Engineering and, by courtesy, of Bioengineering
Current Research and Scholarly Interestscomputaitonal simulation of brain development, cortical folding, computational simulation of cardiac disease, heart failure, left ventricular remodeling, electrophysiology, excitation-contraction coupling, computer-guided surgical planning, patient-specific simulation
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Anshul Kundaje
Associate Professor of Genetics and of Computer Science
Current Research and Scholarly InterestsWe develop statistical and machine learning frameworks to model gene regulation and decipher the genetic and molecular basis of disease
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Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
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Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu).
