Stanford University
Showing 20,801-20,850 of 36,216 Results
-
Nicholas Melosh
Professor of Materials Science and Engineering
BioThe Melosh group explores how to apply new methods from the semiconductor and self-assembly fields to important problems in biology, materials, and energy. We think about how to rationally design engineered interfaces to enhance communication with biological cells and tissues, or to improve energy conversion and materials synthesis. In particular, we are interested in seamlessly integrating inorganic structures together with biology for improved cell transfection and therapies, and designing new materials, often using diamondoid molecules as building blocks.
My group is very interested in how to design new inorganic structures that will seamless integrate with biological systems to address problems that are not feasible by other means. This involves both fundamental work such as to deeply understand how lipid membranes interact with inorganic surfaces, electrokinetic phenomena in biologically relevant solutions, and applying this knowledge into new device designs. Examples of this include “nanostraw” drug delivery platforms for direct delivery or extraction of material through the cell wall using a biomimetic gap-junction made using nanoscale semiconductor processing techniques. We also engineer materials and structures for neural interfaces and electronics pertinent to highly parallel data acquisition and recording. For instance, we have created inorganic electrodes that mimic the hydrophobic banding of natural transmembrane proteins, allowing them to ‘fuse’ into the cell wall, providing a tight electrical junction for solid-state patch clamping. In addition to significant efforts at engineering surfaces at the molecular level, we also work on ‘bridge’ projects that span between engineering and biological/clinical needs. My long history with nano- and microfabrication techniques and their interactions with biological constructs provide the skills necessary to fabricate and analyze new bio-electronic systems.
Research Interests:
Bio-inorganic Interface
Molecular materials at interfaces
Self-Assembly and Nucleation and Growth -
Kathryn Melsop
Director, Finance & Facility Operations, Stanford Laboratory for Cell and Gene Medicine
Current Role at StanfordDirector, Finance and Facility Operations at the Laboratory for Cell & Gene Medicine.
-
Jamie Meltzer
Professor of Art and Art History
BioProfessor Jamie Meltzer teaches in the M.F.A. Program in Documentary Film. His feature documentary films have been broadcast nationally on PBS and have screened at numerous film festivals worldwide. Shifted Landscapes, a documentary feature in production, presents a mosaic of stories depicting the environmental, cultural, and psychological landscapes of California amidst the ongoing climate crisis. His short documentary, not even for a moment do things stand still, premiered at SXSW in March 2022, winning a Special Jury Mention in Visual Reflection. The film provides an observational glimpse into a COVID-19 art installation, dropping into intimate moments of people honoring their loved ones, and interrogating the role of mourning and closure during an unfolding tragedy. It was published as a New York Times Op-Doc in April 2022. Huntsville Station, a short documentary film directed with Chris Filippone, was featured as a New York Times Op-Docs and premiered at Berlinale and SXSW in 2020. The film observes the scene at a bus station - where dozens of inmates just released on parole take in their first moments of freedom before taking the bus home. True Conviction (broadcast on Independent Lens in May 2018), a co-production of ITVS and the recipient of a Sundance Institute grant and a MacArthur grant, premiered at the Tribeca Film Festival where it received a Special Jury Mention in the Best Documentary Feature category. Informant (2012), about a revolutionary activist turned FBI informant, was released in theaters in the US and Canada in Fall 2013 by Music Box Films and KinoSmith. Previous films include: Off the Charts: The Song-Poem Story (Independent Lens, 2003), about the shadowy world of song-poems, Welcome to Nollywood (PBS Broadcast, 2007), an investigation into the wildly successful Nigerian movie industry, and La Caminata (2009), a short film about a small town in Mexico that runs a simulated border crossing as a tourist attraction.
-
Derek Mendez
Staff Scientist, SLAC National Accelerator Laboratory
Current Role at StanfordComputational staff scientist at the Stanford Synchrotron Radiation Lightsource (SSRL), in the Macromolecular Crystallography group (Structural and Molecular Biology division).
Main activities revolve around a 3 year BRaVE-funded project to build a new X-ray resource for the acceleration of medicines development (XMeD). Active in-silico areas of research are in the characterization of crystallization outcomes, virtual and experimental screening of ligands, in-silico methods for lead molecule optimization, and extremely sensitive absorption profile characterization using machine learning techniques. A major computational goal is to determine the most valuable tools (and develop new ones) for future XMeD users.
Beyond XMeD, we are focusing on using GPUs and machine learning models to accelerate processing and characterization of user diffraction data that is collected at SSRL beamlines 12-1, 12-2, 14-1, and 9-2. In addition, we are aiming to make available to users new methods that process X-ray diffraction data at the pixel-level in order to extract more information to better resolve structural changes in proteins arising from e.g., binding events and light/chemical driven dynamics.
We are also partnering with NERSC to build a framework for our beamline users to offload computationally intensive jobs to the Perlmutter GPU cluster. -
Hector Mendez
Postdoctoral Scholar, Cardiovascular Medicine
BioDr. Hector Rodrigo Mendez is a Medical Geneticist from Argentina. Rodrigo completed a residency program in Medical Genetics at Centro Nacional de Genetica Medica – ANLIS (Buenos Aires, Argentina) and a Master’s program in Medical Molecular Biology at Buenos Aires University.
Rodrigo continued his scientific career at a German Genomic Start-up, working as a human geneticist and providing his experience in rare disorders, genomic data (WGS/WES/gene panels) analysis, variant interpretation, and its integration with a deep focus on genotype-phenotype correlation.
Rodrigo’s areas of expertise are rare disorders, NGS technology, Whole Genome Sequencing analysis, and ACMG interpretation guidelines, and his research aims are:
- Collection and analysis of clinical data through deep-learning phenotyping approaches.
- Multi-omic data integration to elucidate complex and rare genetic disorders.
- Drive progress in curing rare genetic diseases, particularly among critically sick infants.
At Stanford University, under the supervision of Dr. Matthew Wheeler, he is conducting his postdoctoral research studies to achieve his scientific goals.
