Wu Tsai Neurosciences Institute
Showing 1-46 of 46 Results
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Weidong Cai
Clinical Associate Professor, Psychiatry and Behavioral Sciences
BioMy research program investigates the neurobiological basis of cognitive dysfunction across the lifespan, focusing on two critical populations: children with neurodevelopmental disorders (e.g., ADHD) and elders with neurodegenerative conditions (e.g., Parkinson’s disease). By employing a highly interdisciplinary approach that integrates cognitive science, advanced functional neuroimaging, and computational modeling, I aim to delineate the neurocognitive processes governing both typical and atypical brain development and aging. The ultimate goal is to advance our understanding of the factors contributing to cognitive deficits and translate these findings into improved diagnostic tools and precision treatment strategies.
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David Camarillo
Associate Professor of Bioengineering and, by courtesy, of Neurosurgery and of Mechanical Engineering
BioDavid B. Camarillo is Associate Professor of Bioengineering, (by courtesy) Mechanical Engineering and Neurosurgery at Stanford University. Dr. Camarillo holds a B.S.E in Mechanical and Aerospace Engineering from Princeton University, a Ph.D. in Mechanical Engineering from Stanford University and completed postdoctoral fellowships in Biophysics at the UCSF and Biodesign Innovation at Stanford. Dr. Camarillo worked in the surgical robotics industry at Intuitive Surgical and Hansen Medical, before launching his laboratory at Stanford in 2012. His current research focuses on precision human measurement for multiple clinical and physiological areas including the brain, heart, lungs, and reproductive system. Dr. Camarillo has been awarded the Hellman Fellowship, the Office of Naval Research Young Investigator Program award, among other honors including multiple best paper awards in brain injury and robotic surgery. His research has been funded by the NIH, NSF, DoD, as well as corporations and private philanthropy. His lab’s research has been featured on NPR, the New York Times, The Washington Post, Science News, ESPN, and TED.com as well as other media outlets aimed at education of the public.
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Jan Carette
Professor of Microbiology and Immunology
Current Research and Scholarly InterestsOur research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use CRISPR genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it may also facilitate the development of new therapeutic strategies.
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Victor G. Carrión
John A. Turner Endowed Professor for Child and Adolescent Psychiatry
Current Research and Scholarly InterestsExamines the interplay between brain development and stress vulnerability via a multi-method approach that includes psychophysiology, neuroimaging, neuroendocrinology and phenomenology. Treatment development that focuses on individual and community-based interventions for stress related conditions in children and adolescents that experience traumatic stress.
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Ian Carroll, MD, MS
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain)
Current Research and Scholarly InterestsWe are committed to promoting an understanding of cerebrospinal fluid (CSF) leaks, and ensuring that all patients who are suffering from cerebrospinal fluid leaks receive appropriate diagnosis and treatment of this devastating, chronic, and fixable condition. We believe this can be best accomplished in a multidisciplinary setting involving expertise in radiology, neurology, and interventional pain medicine.
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Laura L. Carstensen
Director, Stanford Center on Longevity, Fairleigh S. Dickinson, Jr. Professor of Public Policy and Professor, by courtesy, of Health Policy
BioLaura L. Carstensen is Professor of Psychology at Stanford University where she is the Fairleigh S. Dickinson Jr. Professor in Public Policy and founding director of the Stanford Center on Longevity. Her research on the theoretical and empirical study of motivational, cognitive, and emotional aspects of aging has been funded continuously by the National Institute on Aging for more than 30 years. Carstensen is an elected member of the National Academy of Medicine and the American Academy of Arts and Sciences. She served on the MacArthur Foundation’s Research Network on an Aging Society and was a commissioner on the Global Roadmap for Healthy Longevity. Carstensen’s awards include a Guggenheim Fellowship, the Kleemeier Award, The Richard Kalish Award for Innovative Research and distinguished mentor awards from both the Gerontological Society of America and the American Psychological Association. She is the author of A Long Bright Future: Happiness, Health, and Financial Security in an Age of Increased Longevity. Carstensen received her B.S. from the University of Rochester and her Ph.D. in Clinical Psychology from West Virginia University. She holds honorary doctorates from Katholieke Universiteit Leuven and the University of Rochester.
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Lynette Cegelski
Monroe E. Spaght Professor of Chemistry and Professor, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsResearch in the Cegelski laboratory is driven by the need to uncover and define the chemistry that underlies outstanding challenges in human health, the environment, and sustainability. Beyond discovery, we use chemistry as a tool to innovate and create solutions to these pressing problems. The laboratory is highly interdisciplinary, designing experimental approaches to understand how complex biological systems are built, organized, and controlled, and then perturb and influence assembly processes. The lab develops new methods and uniquely leverages: (1) small molecules in new biochemical assay development, chemical genetics approaches, and therapeutic discovery in infectious diseases, (2) fluorescence and electron microscopy coupled to analytical HPLC, mass spectrometry, and complementary biochemical techniques, and (3) spectroscopy, particularly solid-state NMR, to uncover new “dark matter” and define chemistry in insoluble, heterogeneous and complex assemblies relevant to human health, plants, and the ocean.
Long-standing efforts in the laboratory focus on defining mechanisms underlying bacterial biofilm formation and identifying new antibiotic and anti-virulence strategies, including advancing therapeutic candidates for the most difficult-to-treat infections. Through these efforts, we uncovered a new chemical structure in nature: phosphoethanolamine (pEtN) cellulose. Cellulose is the most abundant biopolymer on earth and this discovery provided the first experimental validation of a naturally produced chemically modified cellulose. We are developing alternatively modified celluloses and polysaccharides and advancing new solutions for ecofriendly, sustainably sourced, and recyclable materials. Collectively, our projects span disciplines from molecular structure and assembly chemistry to living microbial communities and natural marine systems, while aiming to translate fundamental discoveries into therapeutic and materials solutions. -
Chris Chafe
Duca Family Professor
BioChris Chafe is a composer, improvisor, and cellist, developing much of his music alongside computer-based research. He is Director of Stanford University's Center for Computer Research in Music and Acoustics (CCRMA). In 2019, he was International Visiting Research Scholar at the Peter Wall Institute for Advanced Studies The University of British Columbia, Visiting Professor at the Politecnico di Torino, and Edgard-Varèse Guest Professor at the Technical University of Berlin. At IRCAM (Paris) and The Banff Centre (Alberta), he has pursued methods for digital synthesis, music performance and real-time internet collaboration. CCRMA's jacktrip project involves live concertizing with musicians the world over. Online collaboration software and research into latency factors continue to evolve. An active performer either on the net or physically present, his music reaches audiences in sometimes novel venues. An early network project was a simultaneous five-country concert was hosted at the United Nations in 2009. Chafe’s works include gallery and museum music installations which are now into their second decade with “musifications” resulting from collaborations with artists, scientists and MD’s. Recent work includes the Earth Symphony, the Brain Stethoscope project (Gnosisong), PolarTide for the 2013 Venice Biennale, Tomato Quintet for the transLife:media Festival at the National Art Museum of China and Sun Shot played by the horns of large ships in the port of St. Johns, Newfoundland.
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Kevin Chuen Wing Chan
Associate Professor of Ophthalmology (Research/Clinical Trials)
Current Research and Scholarly Interests(1) MR ocular imaging and neuroimaging of degeneration, development, protection, plasticity, and regeneration in humans and experimental animal models.
(2) Structural, metabolic, physiological, and functional relationships between eye, brain, and behavior in health and disease. -
Pak H. Chan
The James R. Doty Professor in Neurosurgery and Neurosciences, Emeritus
Current Research and Scholarly InterestsNeuronal death and regeneration after strokeand neural injury
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Howard Y. Chang, MD, PhD
Virginia and D. K. Ludwig Professor of Cancer Research, Professor of Genetics and, by courtesy, of Pathology
On Leave from 12/16/2024 To 12/15/2026Current Research and Scholarly InterestsOur research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.
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Kay W. Chang, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
Current Research and Scholarly Interestshttp://med.stanford.edu/ohns/research/labs_chang.html
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Steven D. Chang, MD
Robert C. and Jeannette Powell Neurosciences Professor and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology and Neurological Sciences
Current Research and Scholarly InterestsClinical research includes studies in the treatment of cerebrovascular disorders, such as aneurysms and AVMs, as well as the use of radiosurgery to treat tumors and vascular malformations of the brain and spine.
Dr. Chang is C0-Director of the Cyberknife Radiosurgery Program.
Dr. Chang is also the head of the The Stanford Neuromolecular Innovation Program with the goal of developing new technologies to improve the diagnosis and treatment of patients affected by neurological conditions. -
Akshay Chaudhari
Associate Professor (Research) of Radiology (Integrative Biomedical Imaging Informatics at Stanford) and of Biomedical Data Science
Current Research and Scholarly InterestsDr. Chaudhari is interested in the application of artificial intelligence techniques to all aspects of medical imaging, including automated schedule and reading prioritization, image reconstruction, quantitative analysis, and prediction of patient outcomes. His interests focus on the development and evaluation new self-supervised and representation learning techniques for multi-modal deep learning in healthcare using vision, language, and medical records data
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Can Chen
Clinical Assistant Professor, Medicine - Primary Care and Population Health
BioDr. Can Chen is a board-certified physician specializing in internal medicine and geriatric medicine, with a clinical focus on post-acute and long-term care. She is a Certified Medical Director by PALTmed (Post-Acute and Long-Term Care Medical Association) and serves as the Medical Director for The Sequoias Portola Valley Continuing Care Residential Community, where she is committed to enhancing the quality of care for senior residents.
Dr. Chen excels in shared decision-making and creating individualized care plans, emphasizing personalized approaches to advance care planning, dementia care, and beyond. Her dedication to improving quality standards in geriatric care extends to her involvement in quality improvement initiatives, interdisciplinary team education, and community education in senior living environments. Dr. Chen actively engages in guiding seniors and their families through the complexities of healthcare and aging, advocating for informed and compassionate care. -
James K. Chen
Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry
Current Research and Scholarly InterestsOur laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.
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Lu Chen
Professor of Neurosurgery and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsWhat distinguishes us humans from other animals is our ability to undergo complex behavior. The synapses are the structural connection between neurons that mediates the communication between neurons, which underlies our various cognitive function. My research program aims to understand the cellular and molecular mechanisms that underlie synapse function during behavior in the developing and mature brain, and how synapse function is altered during mental retardation.
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Xiaoke Chen
Associate Professor of Biology
Current Research and Scholarly InterestsOur goal is to understand how brain circuits mediate motivated behaviors and how maladaptive changes in these circuits cause mood disorders. To achieve this goal, we focus on studying the neural circuits for pain and addiction, as both trigger highly motivated behaviors, whereas, transitioning from acute to chronic pain or from recreational to compulsive drug use involves maladaptive changes of the underlying neuronal circuitry.
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Alan G. Cheng, MD
Edward C. and Amy H. Sewall Professor in the School of Medicine, Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
Current Research and Scholarly InterestsActive Wnt signaling maintains somatic stem cells in many organ systems. Using Wnt target genes as markers, we have characterized distinct cell populations with stem cell behavior in the inner ear, an organ thought to be terminally differentiated. Ongoing work focuses on delineating the developing significance of these putative stem/progenitor cells and their behavior after damage.
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E.J. Chichilnisky
John R. Adler Professor, Professor of Neurosurgery and of Ophthalmology and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsFunctional circuitry of the retina and design of retinal prostheses
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Yueh-hsiu Chien
Professor of Microbiology & Immunology
Current Research and Scholarly InterestsContribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.
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Wah Chiu
Wallenberg-Bienenstock Professor and Professor of Bioengineering and, by courtesy, of Microbiology and Immunology
Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.
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Eun Young Choi, PhD
Instructor, Neurosurgery
Current Research and Scholarly InterestsDr. Choi is broadly interested in mapping the brain’s connectivity and characterizing its functional dynamics using advanced neuroimaging and clinical neurophysiological methods, as well as translating this information to identify individual-specific neurosurgical targets and treatment strategies using neuromodulation (e.g., deep brain stimulation). Her prior work has mapped the functional and connectional organization of the cortex, striatum, and thalamus using neuroimaging and NHP neuroanatomical tract-tracing. She is currently focused on the use of thalamic deep brain stimulation to improve memory and attention in traumatic brain injury and Alzheimer’s disease, and the development of precise, individual-specific adult and pediatric brain atlases and network maps.
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Danny Hung-Chieh Chou
Associate Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
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Steven Chu
William R. Kenan Jr. Professor, Professor of Molecular and Cellular Physiology and of Energy Science and Engineering
Current Research and Scholarly InterestsSynthesis, functionalization and applications of nanoparticle bioprobes for molecular cellular in vivo imaging in biology and biomedicine. Linear and nonlinear difference frequency mixing ultrasound imaging. Lithium metal-sulfur batteries, new approaches to electrochemical splitting of water. CO2 reduction, lithium extraction from salt water
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Thomas Clandinin
Shooter Family Professor
Current Research and Scholarly InterestsThe Clandinin lab focuses on understanding how neuronal circuits assemble and function to perform specific computations and guide behavior. Taking advantage of a rich armamentarium of genetic tools available in the fruit fly, combined with imaging, physiology and analytical techniques drawn from systems neuroscience, we examine a variety of visual circuits.
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David Clark
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD)
BioMy career is dedicated to improving the safety, effectiveness and availability of pain relief. Both the needs and opportunities in these areas are limitless. I have had the good fortune of working as a clinician, teacher and scientist at Stanford University and the Palo Alto VA hospital for more than two decades.
Much of my time is spent on laboratory, translational and clinical research. In the laboratory, we are pursuing several projects related to the questions of why pain sometimes becomes chronic after injuries and why opioids lose their effectiveness over time. Alterations in endogenous pain control mechanisms and the involvement of the adaptive system of immunity are central to these investigations. We would like to find ways to maximize functional recovery after surgery and other forms of trauma while minimizing the risks of analgesic use. This work involves local, national and international collaborations. Clinical trials work involves establishing the efficacy of novel forms of analgesic therapy as well as the comparative effectiveness of long-established approaches to controlling common forms of pain such as low back pain. This spectrum of pain-related pursuits continues to evolve with the rapid expansion of the field. -
Eve Clark
Richard Lyman Professor in the Humanities, Emerita
BioI am interested in first language acquisition, the acquisition of meaning, acquisitional principles in word-formation compared across children and languages, and general semantic and pragmatic issues in the lexicon and in language use. I am currently working on the kinds of pragmatic information adults offer small children as they talk to them, and on children's ability to make use of this information as they make inferences about unfamiliar meanings and about the relations between familiar and unfamiliar words. I am interested in the inferences children make about where to 'place' unfamiliar words, how they identify the relevant semantic domains, and what they can learn about conventional ways to say things based on adult responses to child errors during acquisition. All of these 'activities' involve children and adults placing information in common ground as they interact. Another current interest of mine is the construction of verb paradigms: how do children go from using a single verb form to using forms that contrast in meaning -- on such dimensions as person, number, and tense? How do they learn to distinguish the meanings of homophones? To what extent do they make use of adult input to discern the underlying structure of the system? And how does conversation with more expert speakers (usually adults) foster the acquisition of a first language? I am particularly interested in the general role of practice along with feedback here.
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Michael F. Clarke, M.D.
Karel H. and Avice N. Beekhuis Professor of Cancer Biology
Current Research and Scholarly InterestsDr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and diseases such as cancer and hereditary diseases; and ii) the identification and characterization of cancer stem cells. His laboratory is investigating how perturbations of stem cell regulatory machinery contributes to human disease. In particular, the laboratory is investigating epigenetic regulators of self renewal, the process by which stem cells regenerate themselves.
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Maria Inmaculada Cobos Sillero
Associate Professor of Pathology
Current Research and Scholarly InterestsOur lab uses cellular and molecular methods, single-cell technology, and quantitative histology to study human neurodegenerative diseases. Current projects include:
- Using single-cell RNA-sequencing to understand selective vulnerability and disease progression in human Alzheimer’s disease brain
- Investigating mechanisms of tau-related neurodegeneration in human brain
- Studying the neocortical and limbic systems in Diffuse Lewy Body Disease (DLBD) at the single cell level -
Jennifer R. Cochran
Vice President for SLAC National Accelerator Laboratory and for Strategic Initiatives, Addie and Al Macovski Professor, Professor of Bioengineering and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsMolecular Engineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology
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Stanley N. Cohen, MD
Kwoh-Ting Li Professor in the School of Medicine, Professor of Genetics and of Medicine
On Partial Leave from 06/04/2025 To 07/16/2026Current Research and Scholarly InterestsWe study mechanisms that affect the expression and decay of normal and abnormal mRNAs, and also RNA-related mechanisms that regulate microbial antibiotic resistance. A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of genes.
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Todd Coleman
Associate Professor of Bioengineering and, by courtesy, of Electrical Engineering
BioTodd P. Coleman is an Associate Professor in the Department of Bioengineering, and by courtesy, Electrical Engineering at Stanford University. He received B.S. degrees in electrical engineering (summa cum laude), as well as computer engineering (summa cum laude) from the University of Michigan (Go Blue). He received M.S. and Ph.D. degrees from MIT in electrical engineering and computer science. He did postdoctoral studies at MIT and Mass General Hospital in quantitative neuroscience. He previously was a faculty member in the Departments of Electrical & Computer Engineering and Bioengineering at the University of Illinois, Urbana-Champaign, and the University of California, San Diego, respectively. Dr. Coleman’s research is very multi-disciplinary, using tools from applied probability, physiology, and bioelectronics. Examples include, for instance, optimal transport methods in high-dimensional uncertainty quantification and developing technologies and algorithms to monitor and modulate physiology of the nervous systems in the brain and visceral organs. He has served as a Principal Investigator on grants from the NSF, NIH, Department of Defense, and multiple private foundations. Dr. Coleman is an inventor on 10 granted US patents. He has been selected as a Gilbreth Lecturer for the National Academy of Engineering, a TEDMED speaker, and a Fellow of IEEE as well as the American Institute for Medical and Biological Engineering. He recently served as Chair of the National Academies Standing Committee on Biotechnology Capabilities and National Security Needs.
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Steven Hartley Collins
Associate Professor of Mechanical Engineering and, by courtesy, of Bioengineering
BioSteve Collins is an Associate Professor of Mechanical Engineering at Stanford University, where he teaches courses on design and robotics and directs the Stanford Biomechatronics Laboratory. His primary focus is to speed and systematize the design and prescription of prostheses and exoskeletons using versatile device emulator hardware and human-in-the-loop optimization algorithms (Zhang et al. 2017, Science). Another interest is efficient autonomous devices, such as highly energy-efficient walking robots (Collins et al. 2005, Science) and exoskeletons that use no energy yet reduce the metabolic energy cost of human walking (Collins et al. 2015, Nature).
Prof. Collins received his B.S. in Mechanical Engineering in 2002 from Cornell University, where he performed undergraduate research on passive dynamic walking robots. He received his Ph.D. in Mechanical Engineering in 2008 from the University of Michigan, where he performed research on the dynamics and control of human walking. He performed postdoctoral research on humanoid robots at T. U. Delft in the Netherlands. He was a professor of Mechanical Engineering and Robotics at Carnegie Mellon University for seven years. In 2017, he joined the faculty of Mechanical Engineering at Stanford University.
Prof. Collins is a member of the Scientific Board of Dynamic Walking and the Editorial Board of Science Robotics. He has received the Young Scientist Award from the American Society of Biomechanics, the Best Medical Devices Paper from the International Conference on Robotics and Automation, and the student-voted Professor of the Year in his department. -
Le Cong
Associate Professor of Pathology (Pathology Research) and of Genetics
Current Research and Scholarly InterestsOur lab develops gene-editing technologies like novel CRISPR systems and large gene insertion techniques for gene and cell therapy. We also leverage these gene-editing tools for single-cell functional screening to probe mechanisms of cancer, immunological, and aging-associated diseases. To accelerate our work, we integrate AI and machine learning to design and evolve therapeutic RNAs/proteins, and build AI-XR co-scientists like LabOS that bridge AI computation and biomedical experimentation.
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Christos E. Constantinou
Associate Professor of Urology, Emeritus
Current Research and Scholarly InterestsMy main recent interest is the application of Biomedical Engineering approaches for the clinical visualization and characterization of the static and dynamic properties of pelvic floor function. This extends to ultrasound Imaging and image processing, construction of computer models and biomechanics analysis of pelvic floor function. It is envisioned that these considerations are important constituents of the clinical evaluation of patients with lower urinary tract dysfunction and urodynamics.
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Simon Conti
Clinical Associate Professor, Urology
BioI am a founding member of the Stanford Urolithiasis Project, where we have studied population health datasets to examine surgical outcomes and environmental risk factors in urinary stone disease. Our current focus includes socioeconomic and ethnic disparities in kidney stone disease, water quality and stone disease, pregnancy in kidney stone disease and geographical variations in kidney stones incidence and metabolic kidney stone work up.
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Ximena Corso Díaz
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in unraveling the roles of RNA-binding proteins (RBPs) and regulatory RNAs in retinal development and homeostasis.
RNA-binding proteins mediate functional integration of transcriptional and post-transcriptional machineries influencing various aspects of gene expression and RNA metabolism. Several RBPs have cell-type enriched expression patterns in the retina or cause blinding diseases, however their role in retinal development and function is poorly understood. We have identified several RBPs that interact with the photoreceptor-specific transcription factor NRL and are likely involved in development and homeostasis of this retinal cell-type. We are pursuing the following lines of research:
1) RBPs in retinal development and degeneration. We will study the role of RBPs in regulating retinal development and maintaining homeostasis. We will focus on RBPs enriched in the retina, their interactions with retinal transcription factors like NRL, and their relevance to retinal diseases.
2) RBPs in R-loop regulation in the retina. R-loops are triple-stranded structures created when RNA anneals to one of the strands of the DNA duplex. R-loops have many regulatory roles during gene expression and their dysregulation can be detrimental to genome integrity. We observed that R-loops are dynamic during retinal development and identified key R-loop-associated RBPs that are enriched in rod photoreceptors and that interact with the transcription factor NRL. We will study the role of R-loops and their regulatory RBPs in retinal development and homeostasis.
3) Chromatin-associated regulatory RNAs through the retina lifespan. Chromatin-associated RNAs contribute to the dynamic regulation of gene expression, chromatin structure, and genome organization, playing essential roles in various biological processes, including development, differentiation, and disease. We will study how regulatory RNAs, together with their cognate RBPs, influence expression programs and chromatin dynamics through the retina lifespan. -
Graham Creasey
Paralyzed Veterans of America Professor of Spinal Cord Injury Medicine, Emeritus
Current Research and Scholarly InterestsNeural prostheses to stimulate and record from the peripheral and central nervous system, thereby directly connecting nervous systems with electronic systems
Neural prostheses for control of bladder, bowel and sexual function after spinal cord injury -
Bianxiao Cui
Job and Gertrud Tamaki Professor of Chemistry
Current Research and Scholarly InterestsOur objective is to develop new biophysical methods to advance current understandings of cellular machinery in the complicated environment of living cells. Currently, we are focusing on four research areas: (1) Membrane curvature at the nano-bio interface; (2) Nanoelectrode arrays (NEAs) for scalable intracellular electrophysiology; (3) Electrochromic optical recording (ECORE) for neuroscience; and (4) Optical control of neurotrophin receptor tyrosine kinases.
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Yi Cui
Fortinet Founders Professor, Professor of Materials Science and Engineering, of Energy Science and Engineering, of Photon Science, Senior Fellow at Woods, at Precourt and Professor, by courtesy, of Chemistry
BioCui studies fundamentals and applications of nanomaterials and develops tools for their understanding. Research Interests: nanotechnology, batteries, electrocatalysis, wearables, 2D materials, environmental technology (water, air, soil), cryogenic electron microscopy.
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Mark Cutkosky
Fletcher Jones Professor in the School of Engineering
BioCutkosky applies analyses, simulations, and experiments to the design and control of robotic hands, tactile sensors, and devices for human/computer interaction. In manufacturing, his work focuses on design tools for rapid prototyping.
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Meg Cychosz
Assistant Professor of Linguistics
BioDr. Cychosz investigates how infants and children develop speech and language, including children who are d/Deaf or hard-of-hearing and multilingual learners. Her research bridges linguistics, cognitive science, developmental psychology, and electrical engineering to understand fundamental questions about language acquisition. Her interdisciplinary approach combines fieldwork with computational methods, using deep learning and automatic speech recognition tools to analyze naturalistic speech recordings from children's daily lives. She is particularly interested in how children's processing limitations might influence the structure of the world's languages, how sensory experiences like hearing loss affect language processing in early childhood, and how technological innovations can make language research more accessible and representative. Dr. Cychosz directs the Speech and Cognitive Development Lab and collaborates with clinical partners in audiology and speech-language pathology to ensure her research has translational impact to support children's language development.
