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Associate Professor of Mechanical Engineering, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Radiology (Precision Health and Integrated Diagnostics)
Current Research and Scholarly InterestsThe long-term goal of Dr. Tang's research program is to harness mass transport in microfluidic systems to accelerate precision medicine and material design for a future with better health and environmental sustainability.
Current research areas include: (I) Physics of droplets in microfluidic systems, (II) Interfacial mass transport and self-assembly, and (III) Applications in food allergy, single-cell wound repair, and the bottom-up construction of synthetic cell and tissues in close collaboration with clinicians and biochemists at the Stanford School of Medicine, UCSF, and University of Michigan.
For details see https://web.stanford.edu/group/tanglab/
William Abraham Tarpeh
Assistant Professor of Chemical Engineering, by courtesy, of Civil and Environmental Engineering and Center Fellow, by courtesy, at the Woods Institute for the Environment
BioReimagining liquid waste streams as resources can lead to recovery of valuable products and more efficient, less costly approaches to reducing harmful discharges to the environment. Pollutants in effluent streams can be captured and used as valuable inputs to other processes. For example, municipal wastewater contains resources like energy, water, nutrients, and metals. The Tarpeh Lab develops and evaluates novel approaches to resource recovery from “waste” waters at several synergistic scales: molecular mechanisms of chemical transport and transformation; novel unit processes that increase resource efficiency; and systems-level assessments that identify optimization opportunities. We employ understanding of electrochemistry, separations, thermodynamics, kinetics, and reactor design to preferentially recover resources from waste. We leverage these molecular-scale insights to increase the sustainability of engineered processes in terms of energy, environmental impact, and cost.
Professor of Energy Resources Engineering
Current Research and Scholarly InterestsEnvironmental fluid mechanics, Applied and computational mathematics, Biomedical modeling.
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain) at the Stanford University Medical Center
Current Research and Scholarly InterestsMy overall research interest is to understand how the immune system interacts with the nervous system after injury to promote the transition from acute to chronic pain. In my clinical practice I care for patients with persistent pain that often occurs after minor trauma such as fracture or surgery. Using basic science approaches including whole system immune phenotyping with mass cytometry and genetic manipulation of peripheral and central immune cells, we seek to dissect the temporal and tissue-specific contribution of these cells to either promotion or inhibition of healing.
Mary Frances Nunez Teruel
Current Research and Scholarly InterestsThe Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, CRISPR libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and tissue renegeneration, with a particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity.
Assistant Professor of Radiology (Pediatric Radiology) at the Stanford University Medical Center
Current Research and Scholarly InterestsOver the past decade there has been tremendous advances in the field of Interventional Oncology with the clinical utilization of multiple new innovative locoregional therapies (i.e. chemoembolization, percutaneous ablation). Looking forward, our ability to superselectively deliver new therapies such as nanoparticles, stem cells and gene therapy will open new pathways for Interventional Radiology into the emerging field of Regenerative Medicine.
Assistant Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly InterestsThe long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly InterestsMy research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly InterestsWe develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.
Professor of Medicine (Gastroenterology and Hepatology) at the Stanford University Medical Center
Current Research and Scholarly InterestsMy laboratory has been focusing on the mechanism of liver fibrogenesis and the role of hepatocyte cell death in fibrogenic injury. We have demonstrated the intricate link between hepatocyte cell death, generation of apoptotic bodies and their phagocytosis by stellate cells triggering fibrogenic activation. Key to this was the activation of the NADPH oxidase and production of reactive oxidative species inducing stellate cell transdifferentiation and collagen I transcription (Gastroenterology, 2010).
We have expanded our work focusing on the role of non-phagocytic NADPH oxidases including NOX4 in dysregulating insulin responses and precipitating stress signaling in non-alcoholic steatohepatitis. (Gastroenterology, 2015). As patients with type II diabetes mellitus develop more progressive liver disease we are now studying how advanced glycation end products (AGEs) engage RAGE signaling in the liver and NADPH oxidase-mediated redox stress.
Our ultimate goal is to translate our findings and develop novel therapeutic approaches that reverse fibrosis in NASH and improve patient outcomes.