School of Engineering
Showing 2,761-2,780 of 6,563 Results
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Makrand Khanwale
Physical Science Research Scientist
BioI received my PhD from Iowa State University co-majoring in Mechanical engineering and Applied Mathematics. I was co-advised by Dr. Baskar Ganapathysubramanian and Dr. James Rossmanith. For my dissertation I worked on development and analysis of numerical schemes for high fidelity simulations of multiphase flows. Specifically I developed energy stable numerical methods to simulate two-phase flows using Cahn-Hilliard Navier-Stokes equations. I also have experience in development of tools to analyse and understand complex physical processes like multi-phase flows and turbulence. Before joining Iowa State for my graduate work, I had a brief stint as a research associate in Dr. Krishnaswamy Nandakumar‘s group in Louisiana State University (LSU). At LSU I worked on developing theoretical models for energy cascades in multi-phase flows.
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Oussama Khatib
Weichai Professor and Professor, by courtesy, of Electrical Engineering
BioRobotics research on novel control architectures, algorithms, sensing, and human-friendly designs for advanced capabilities in complex environments. With a focus on enabling robots to interact cooperatively and safely with humans and the physical world, these studies bring understanding of human movements for therapy, athletic training, and performance enhancement. Our work on understanding human cognitive task representation and physical skills is enabling transfer for increased robot autonomy. With these core capabilities, we are exploring applications in healthcare and wellness, industry and service, farms and smart cities, and dangerous and unreachable settings -- deep in oceans, mines, and space.
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine.
