School of Medicine
Showing 2,901-2,950 of 4,342 Results
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Vijay Pande
Adjunct Professor, Structural Biology Department
BioVijay Pande, Henry Dreyfus Professor of Chemistry and, by courtesy, of Structural Biology and Computer Science, also currently directs of the Stanford Program in Biophysics and the Folding@home Distribtued Computing project. His research centers on novel cloud computing simulation techniques to address problems in chemical biology. In particular, he has pioneered distributed computing methodology to break fundamental barriers in the simulation of protein and nucleic acid kinetics and thermodynamics. As director of the Folding@home project (http://folding.stanford.edu), Prof. Pande has, for the first time, directly simulated protein folding dynamics, making quantitative comparisons with experimental results, often considered a “holy grail” of computational biology. His current research also includes novel computational methods for drug design, especially in the area of protein misfolding and associated diseases such as Alzheimer’s and Huntington’s Disease.
Professor Pande studied physics at Princeton University (B.A. 1992), where he was first introduced to biophysical questions, especially in undergraduate research with Nobel Laureate P. Anderson. His doctoral research in physics under Profs. T. Tanaka and A. Grosberg at MIT (Ph.D. 1995) centered on statistical mechanical models of protein folding, suggesting new ways to design protein sequences for stability and folding properties. As a Miller Fellow under Prof. D. Rokhsar at UC Berkeley, Prof. Pande extended this methodology to examine atomistic protein models, laying the foundations for his work at Stanford University. Among numerous awards, Prof. Pande has received the Biophysical Society’s Bárány Award for Young Investigators and Protein Society’s Irving Sigal Young Investigator Award, and was named to MIT’s TR100 and elected a Fellow of the American Physical Society.
The Pande research group develops and applies new theoretical methods to understand the physical properties of biological molecules such as proteins, nucleic acids and lipid membranes, using this understanding to design synthetic systems including small-molecule therapeutics. In particular, the group examines the self-assembly properties of biomolecules. For example, how do protein and RNA molecules fold? How do proteins misfold and aggregate? How can we use this understanding to tackle misfolding related degeneration and develop small molecules to inhibit disease processes?
As these phenomena are complex, spanning molecular to mesoscopic lengths and nanosecond to millisecond timescales, the lab employs a variety of methods, including statistical mechanical analytic models, Markov State Models, and statistical and informatic methods. Other tools include Monte Carlo, Langevin dynamics, and molecular dynamics computer simulations on workstations and massively parallel supercomputers, superclusters, and worldwide distributed computing. The group has also done extensive work in the application of machine learning, pioneering traditional and deep learning approaches to cheminformatics, biophysics and drug design.
For example, simulations in all-atom detail on experimentally relevant timescales (milliseconds to seconds) have produced specific predictions of the structural and physical chemical nature of protein aggregation involved in Alzheimer’s and Huntington’s diseases. These results have fed into computational small molecule drug design methods, yielding interesting new chemical entities.
Since such problems are extremely computationally demanding, the group developed a distributed computing project for protein folding dynamics. Since its launch in October 2000, Folding@Home has attracted more than 4,000,000 PCs, and today is recognized as the most powerful supercluster in the world. Such enormous computational resources have allowed simulations of unprecedented folding timescales and statistical precision and accuracy. For more details, please visit http://pande.stanford.edu. -
Heather Ryan Pankow
Life Science Rsch Prof 2, Psych/General Psychiatry and Psychology (Adult)
Current Role at StanfordLife Science Research Professional 2 in The Depression Research Clinic
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Lori D Panu
Sr. Program Manager, Clinical Research Operations, Med/Stanford Center for Clinical Research
Current Role at StanfordSr. Program Manager, Clinical Research Operations
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Vedant Pargaonkar
Basic Life Research Scientist, Medicine - Med/Cardiovascular Medicine
BioMy long-term research interests involve development of algorithms using computational methods for early detection of coronary pathophysiology including, endothelial dysfunction and microvascular dysfunction (MVD) and/or a myocardial bridge (MB) in patients with angina and no obstructive coronary artery disease (NOCAD) and the identification of novel target therapies for primary prevention and improved prognosis in these patients. Under the mentorship of Dr. Jennifer Tremmel in Cardiovascular medicine at Stanford, I have been systematically studying to better understand the underlying pathophysiology of these patients, as well as the optimal use of diagnostic testing and treatment using the angina and no-obstructive CAD Registry at Stanford. In collaboration with other investigators in this field, we have published multiple scientific articles highlighting the limitations of current testing in this population and identification of novel diagnostic tools for early diagnosis and management of patients with angina and no obstructive CAD. My research also focuses on myocardial infarction (MI) in women, particularly spontaneous coronary artery dissection (SCAD). I have been involved in the design and execution of the first international collaborative study in SCAD, investigating peripartum vs. non-peripartum SCAD. This is analyzing the largest cohort of patients recruited from multiple US and non-US sites to understand the pathophysiological differences in these patient cohorts.
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Mitchel Pariani
Clinical Assistant Professor (Affiliated), Pediatrics - Genetics
BioMitchel earned his Master’s degree in genetic counseling from California State University, Northridge in 2007. At Cedars-Sinai Medical Center Mitchel served as genetic counselor and coordinator for David Rimoin, MD, PhD’s connective tissue disorders clinic and later established the cardiovascular genetics program at CSMC. At CSMC he also created the CSMC Summer Genetic Counseling Rotation Program that hosted students from genetic counseling programs around the United States. In 2014 he joined the new Stanford Center for Inherited Cardiovascular Disease to start a familial hypercholesterolemia clinic and provide genetic counseling for patients with cardiomyopathies. As the center expanded, Mitchel joined the Stanford Marfan Center as a genetic counselor and serves as program coordinator. He is the primary instructor for Stanford’s Cardiovascular Genetics course and serves as a clinical supervisor and mentor for students and volunteers.
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Jun Hyung Park
Research and Development Science and Engineer 1, Rad/Molecular Imaging Program at Stanford
Current Role at StanfordI joined in Stanford Cyclotron and Radiochemistry Facility in 2014. I focus on routine radiopharmaceutical production, development, optimization for clinical use and supporting various of pre-clinical studies.
18F tracers; 18F-Flumazenil, 18F-FTC-146, 18F-FLT, 18F MISO, 18F AraG, 18F-FSPG etc.
11C tracers; 11C UCB-J, 11C-raclopride, 11C-PIB, 11C-methionine, 11C DPA-713, 11C MGX10, 11, 11C-CN radiochemistry platform development
15O tracers; 15O-H2O, 15O gas Inhalation study
68Ga tracers; 68Ga-DOTATATE, 68Ga-PSMA
Quality Controls; HPLC, GC, TCD GC etc. -
KT Park MD MS
Adjunct Professor, Medicine - Med/Gastroenterology and Hepatology
BioPrior to joining Genentech in 2018, Dr. Park was Associate Professor at Stanford University School of Medicine, Co-Director of the IBD Center at Stanford Children’s Health, and an expert in Crohn’s disease and ulcerative colitis. Currently, he is the Global Head of Gastroenterology, Hepatology & Metabolism in Product Development at Genentech and Roche. Trained as a health economist, during his tenure in academia, Dr Park held research grants and funding support focused on the cost-effectiveness of biologic treatment strategies and novel non-invasive biomarkers for children and adults with IBD. He led national research registries at the Crohn’s & Colitis Foundation and scientific/clinical committees in numerous GI societies and physicians’ organizations. He received his BA in chemistry/biochemistry at Duke University, MD at University of Tennessee, and MSc in Health Economics/Policy at Stanford where he completed his clinical and postdoctoral trainings. He is Adjunct Professor of Medicine in the Division of Gastroenterology & Hepatology at Stanford University. At Genentech Roche, Dr. Park directs a team of clinical scientists and medical directors overseeing clinical phase drug development in gastroenterology, hepatology, and metabolism.
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Ugur Parlatan
Basic Life Research Scientist, Rad/Canary Center at Stanford for Cancer Early Detection
BioDr. Ugur Parlatan is a Basic Life Research Scientist at the Canary Center at Stanford for Cancer Early Detection. Trained as a physicist, he leads photonics laboratory activities and develops optical spectroscopy and imaging approaches for molecular fingerprinting and characterization of extracellular vesicles (EVs). His work includes designing and optimizing measurement workflows, analyzing EV signatures from biomedical samples, and supporting disease-focused studies across cancer and metabolic conditions (including lung cancer, glioblastoma, pancreatic cancer, diabetes, and hepatotoxicity). He also mentors trainees (including NIH CREST program interns) and contributes to manuscripts and grant applications.
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Susan Julia Parson
Clinical Assistant Professor (Affiliated), Pathology Clinical
Staff, Pathology Operations supported expensesBioAssistant Medical Examiner-Coroner / Forensic Pathologist
Santa Clara County Office of the Medical Examiner-Coroner
850 Thornton Way San Jose, CA 95128
(408) 793-1900
https://mec.santaclaracounty.gov/home
