School of Medicine
Showing 401-500 of 958 Results
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Emily Clair McClung, MD, FACOG
Clinical Assistant Professor, Obstetrics & Gynecology - Gynecologic Oncology
BioDr. McClung is a fellowship trained, board certified Gynecologic Oncologist with the Stanford Medicine Cancer Center and Clinical Assistant Professor in the Stanford Medicine Department of Obstetrics and Gynecology, Division of Gynecologic Oncology.
She graduated from the Icahn School of Medicine at Mount Sinai in New York City and she completed residency in Obstetrics and Gynecology at Stanford Medicine. She then pursued sub-specialty Gynecologic Oncology fellowship at Moffitt Cancer Center and the University of South Florida in Tampa, Florida.
Prior to joining Stanford Health Care, Dr. McClung was an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Arizona Banner University Medical Center in Tucson, Arizona.
Dr. McClung actively contributes to gynecologic cancer research. She has studied prevention of surgical site infections, gene expression prediction of lymph node metastasis in endometrial cancer, treatment resistance in ovarian cancer, and additional topics. She co-authored articles on her findings for peer-reviewed publications such as the International Journal of Gynecologic Cancer, International Journal of Women’s Health, and Gynecologic Oncology Reports.
She authored the chapter on the diagnosis and management of vaginal cancer in the textbook Handbook of Gynecology and has made invited presentations at meetings of the Society of Gynecologic Oncology and other associations. She works to improve patient access to state-of-the-art care as an investigator in cooperative group clinical trials.
She has won multiple teaching awards for her work with medical students and residents. She is passionate about increasing awareness of gynecologic cancer in medical trainees.
Dr. McClung provides comprehensive care with a personalized approach for patients with gynecologic cancer and pre-cancer including surgery, chemotherapy, cancer risk reduction, and palliative care. She has a strong clinical interest in patient safety and quality of life both during and after cancer treatment. -
Michael V. McConnell, MD, MSEE
Clinical Professor, Medicine - Cardiovascular Medicine
Current Research and Scholarly InterestsMy imaging research has involved clinical and molecular Imaging of cardiovascular disease, with a focus on coronary and vascular diseases, including atherosclerosis, aortic aneurysms, and vascular inflammation.
My prevention research has involved innovative technologies to reduce coronary and vascular disease, including early disease detection plus leveraging mobile health and AI to enhance heart heart in patients and populations. -
Jamie McDonald, MD, MS
Clinical Assistant Professor, Adult Neurology
BioDr. McDonald is a fellowship-trained, board-certified neurologist and clinical assistant professor in the Department of Neurology at Stanford University School of Medicine.
She specializes in the diagnosis and treatment of multiple sclerosis and other demyelinating diseases, including neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD). Dr. McDonald also provides comprehensive care to general neurology patients.
Dr. McDonald completed her internship and adult neurology residency at the University of Utah. She has a long-standing interest in multiple sclerosis care and went on to complete a two-year clinical MS/neuroimmunology fellowship at Stanford Health Care Multiple Sclerosis Center. Dr. McDonald received the National MS Society’s Sylvia Lawry Physician Fellowship, including formalized training in conducting clinical trials. As part of her fellowship, she completed a master’s degree in epidemiology and clinical research. -
Valerie McDonald, MD, PhD
Affiliate, Department Funds
Resident in MedicineBioValerie McDonald received her MD degree from the University of Washington. During medical school, she performed research exploring correlation of a Physical Activity Vital Sign with healthcare system utilization. She is currently a resident physician in Internal Medicine at Stanford Health Care. Her career interests are patient care, research/QI, and innovation in the intersection of cardiovascular and metabolic health.
Prior to medical school, Valerie earned her PhD in environmental engineering at Michigan Technology University, studying sustainable wastewater treatment. She went on to a post-doc fellowship at the Yale Center for Biospheric Studies and Center for Green Chemistry, studying sustainability in stormwater management. She worked as a Professional Engineer for 10 years, consulting on water supply and water quality improvement projects for cities and counties throughout the Western US. -
Sean McGhee
Clinical Professor, Pediatrics - Immunology
Current Research and Scholarly InterestsBioinformatics
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LAWRENCE McGLYNN
Clinical Professor, Psychiatry and Behavioral Sciences - Medical Psychiatry
Current Research and Scholarly InterestsMethamphetamine Abuse
HIV Neuropsychiatry -
Mark McGovern
Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences) and, by courtesy, of Pediatrics
BioDr. Mark McGovern is a Professor and the Associate Chair of Translation and Implementation Research in the Department of Psychiatry & Behavioral Sciences and, by courtesy, the Department of Medicine at Stanford University School of Medicine.
Most people who need health care do not receive it. And of those who do, wide variation exists in access to care and the quality of the care they receive in health care systems, both private and public. Dr. McGovern is a leader in using rigorous methods of implementation science to close these gaps in health care delivery.
His mission is to get the best health care possible to the people who need it the most.
Dr. McGovern's primary focus is the implementation and sustainment of evidence-based interventions and guideline adherent care in public and private health care systems and organizations. Within the hub of the Stanford Center for Dissemination and Implementation (CDI) which he directs, Dr. McGovern is the Principal Investigator (PI) and leads three national implementation research and practice centers: The Center for Dissemination and Implementation At Stanford (C-DIAS); The Research Adoption Support Center (RASC); and, the Mental Health Technology Transfer Center Network Coordinating Center (MHTTC). The 3 centers are federally-funded, respectively by the National Institute on Drug Abuse (P50DA05402), the National Institutes of Health Healing Addiction Long Term (HEAL) initiative (U2CDA057717), and the US Department of Health and Human Services Substance Use and Mental Health Services Administration (H79SM081726). Dr. McGovern is also the PI on a multi-site adaptive implementation trial across a state system of care, which aims to integrate addiction medications for persons with opioid use disorder who are receiving services in specialty or primary care organizations (R01DA052975). In addition, he addresses implementation challenges in federally-qualified health centers (FQHCs) across the State of California, in the Stanford Division of Primary Care and Population Health, and in specialty addiction and mental health treatment organizations nationwide. He leads, facilitates and/or actively engages networks advancing implementation science in health, including the NIDA Clinical Trials Network Translation & Implementation Special Interest Group, the NIDA Clinical Trials Western States Node Translation & Implementation Workgroup, the Stanford University Network for Dissemination & Implementation Research (SUNDIR), the VA Palo Alto HSR&D Center for Innovation to Implementation, and the Stanford Medicine Center for Improvement. He is on the Core Faculty of the National Institute of Mental Health Implementation Research Institute at the Washington University in St. Louis. Dr. McGovern is a collaborator on multiple projects as a co-investigator, consultant, or advisory board member. He is a mentor to numerous individuals across the country and at Stanford, from university undergraduates to mid-career faculty and clinical administrators at academic institutions and health care systems nationwide. -
Lettie McGuire, EdM
Web Developer 1, Genetics
BioHarvard Graduate School of Education
Neuroscience Informed Research Design -
Steven Lee Mcintire
Clinical Associate Professor, Adult Neurology
BioDr. McIntire earned his MD from Harvard Medical School and his PhD in Neuroscience from Harvard University, where he was awarded a Frank Knox Memorial Fellowship and Carl Walter Fellowship. He then completed Neurology residency training at UCSF. He is board certified in Neurology by the American Board of Psychiatry and Neurology. He has been named a Robert Ebert Clinical Scholar and Culpepper Medical Science Scholar. Dr. McIntire has published extensively in the fields of molecular neurobiology and neurogenetics.
Dr. McIntire’s interests are in general/comprehensive neurology. He is also interested in medical education and the training of medical students and neurology residents. -
Marina Mitchell McIver
Clinical Instructor (Affiliated), School of Medicine - Senior Associate Dean for Medical Student Education
BioMarina McIver, NP, ANP-BC, WHNP-BC, is an advanced practice provider in the department of Internal Medicine at Stanford Health Care. She specializes in Adult Primary Care. She graduated with her Adult Nurse Practitioner (ANP) and Women's Health Nurse Practitioner (WHNP) degree's from Yale University School of Nursing.
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David B. McKay
Professor of Structural Biology, Emeritus
Current Research and Scholarly InterestsThree-dimensional structure determination and biophysical studies of macromolecules.
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Stephen Lawrence McKenna, MD
Clinical Professor (Affiliated), Neurosurgery
Staff, Neurosurgery OperationsBioDr. Stephen McKenna is a founding member of the Stanford Partnership for Spinal Cord Injury and Repair. He is currently the Chief of the Rehabilitation Trauma Center; as well as, the site director of the Advanced SCI Medicine Fellowship at SCVMC.
As a Neurocritical Care physician, Dr. McKenna specializes in ventilator-dependent Spinal Cord and Traumatic Brain Injury, as well as neuromuscular diseases. He has led first-in-human clinical trials ranging from vaccines for HIV to stem cell-derived oligodendrocyte progenitor cell-based therapies for SCI. Dr. McKenna is Chairman of the Respiratory Section of the International Standards to Document Autonomic Function after SCI (ISAFSCI) and co-chair of the American Spinal Cord Injury Association (ASIA) Research Education Subcommittee.
Clinical Focus:
Spinal Cord Injury
Traumatic Brain Injury
Amyotrophic lateral sclerosis (ALS)
Guillain-Barre syndrome (GBS)
Anti-NMDA receptor encephalitis
Neuromyelitis Optica (Devic disease)
Professional Education:
Board Certification: Neurocritical Care, UCNS (2008)
Board Certification: Internal Medicine, ABIM (2005)
Internship & Residency: Santa Clara Valley Medical Center (2002,2005)
Medical Education: Stanford University School of Medicine (2002)
Book Chapter:
Shah A, Shem K, McKenna SL, Berlly M. Management of Respiratory Failure in Spinal Cord Injury. Spinal Cord Medicine (Hardcover) by Steven, M.D. Kirshblum (Editor) Lippincott Williams & Wilkins; 2011
Selected Publications:
Exploration of surgical blood pressure management & expected motor recovery in individuals with traumatic SCI.
Ehsanian R, et al, McKenna SL.
Spinal Cord. 2020 Mar;58(3):377-386. PMID: 31649323
A Novel Pharyngeal Clearance Maneuver for Initial Tracheostomy Tube Cuff Deflation in High Cervical Tetraplegia.
Ehsanian R, et al, McKenna S.
Am J Phys Med Rehabil. 2019 Sep;98(9):835-838. PMID: 30973517
Burden of Care Implications & Association of Intracranial Hypertension with Extremely Severe Post-traumatic Amnesia After TBI: A 5-Year Retrospective Longitudinal Study.
Quach NT, et al
Front Neurol. 2019 Jan 29;10:34. PMID: 30761071
Venous Thromboembolism is Associated with Lack of Vitamin D Supplementation in Patients with SCI & Low Vitamin D Levels.
Ehsanian R, et al
PM R. 2019 Feb;11(2):125-134. PMID: 30300766
Pulmonary outcomes following specialized respiratory management for acute cervical SCI: a retrospective analysis.
Zakrasek EC, et al, McKenna SL
Spinal Cord, 2017; Feb 21. PMID: 28220822
Dose Response Effect of Exposure to Hypotension on Expected Neurological Recovery in Individuals with Traumatic SCI.
ARCHIVES OF PM&R
Reza, E., et al, McKenna, S.
2016: DOI: http://dx.doi.org/10.1016/j.apmr.2016.09.016
Combined SCI & TBI: recovery of forelimb function after unilateral cervical SCI is retarded by contralateral traumatic brain injury (TBI), & ipsilateral TBI balances the effects of SCI on paw placement.
EXPERIMENTAL NEUROLOGY
Inoue T, et al.
2013 Oct 248: 136-47. PMID: 23770071
Functional electrical stimulation in SCI respiratory care.
TOPICS IN SPINAL CORD REHAB.
R Jarosz, et al, S McKenna
2012:Vol. 18, No. 4, 315-321. PMID: 23459661
Impact of mean arterial blood pressure during the first seven days post SCI.
TOPICS IN SPINAL CORD REHAB.
J Cohn, et al
2010: DOI: http://dx.doi.org/10.1310/sci1503-96
Successful Pregnancy & Delivery in a C1 ASIA A spinal cord injured Woman: The Role of Coordinated Care Between PM&R & Obstetrics Services: A Case Report.
PM&R
Lin C, et al
2010: DOI: http://dx.doi.org/10.1016/j.pmrj.2010.07.461
The impact of project closure on HIV incidence and mortality in a cohort of couples in Lusaka, Zambia.
AIDS CARE
Stephenson R, et al
2008 Jul;20(6):683-91. PMID: 18576170
Rapid HIV testing & counseling for voluntary testing centers in Africa.
AIDS
McKenna SL et al
1997 Sep;11 Suppl 1:S103-10. PMID: 9376093 -
Rebecca Mckenzie
Clinical Assistant Professor, Pediatrics - General Pediatrics
Current Research and Scholarly InterestsPediatric liver transplant, outcomes, adherence, transition, liver failure
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Safyer McKenzie-Sampson
Member, Maternal & Child Health Research Institute (MCHRI)
BioSafyer McKenzie-Sampson is an IDEAL Provostial Fellow and instructor within the Department of Pediatrics at Stanford University. Dr. McKenzie-Sampson is a social and perinatal epidemiologist, focused on researching the multi-level impacts of exposure to racism across the life course on the risk of adverse perinatal outcomes in Black communities, with the goal of translating findings into interventions to increase birth justice. Her research portfolio uniquely interrogates the rates of adverse perinatal outcomes through the lens of maternal nativity in the United States which allows for focus on the experiences of Black immigrants. She is currently the principal investigator of the AZANIA study, a mixed methods pilot study which collects data on the pregnancy and childbirth experiences of African immigrants in California. Dr. McKenzie-Sampson received her PhD in Epidemiology and Translational Science from the University of California San Francisco, and in addition to her research, she supports families in the Bay Area as a full-spectrum community doula.
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Tracey McLaughlin
Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsDr. McLaughlin conducts clinical research related to obesity, insulin resistance, diabetes, and cardiovascular disease (CVD). Current studies include: 1) the impact of macronutrient composition on metabolism, DM2 and CVD; 2) comparison of different weight loss diets on metabolism and CVD risk reduction ; 3) role of adipocytes and adipose tissue immune cells in modulating insulin resistance; 4) use of continuous glucose monitoring and multi-omics to define metabolic phenotype and precision diets
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Carmen McLean
Clinical Professor (Affiliated), Psych/General Psychiatry and Psychology (Adult)
BioCarmen McLean, PhD, is a clinical psychologist and researcher with the Dissemination and Training Division of the National Center for PTSD at the Palo Alto VA Health Care System. Dr. McLean’s research focuses on increasing the implementation and reach of evidence-based treatments for posttraumatic stress disorder (PTSD).
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Uel Jackson McMahan
Professor of Neurobiology and of Structural Biology, Emeritus
Current Research and Scholarly InterestsWe are currently investigating mechanisms involved in synaptic transmission and synaptogenesis using electron microscope tomography in ways that provide in situ 3D structural information at macromolecular resolution.
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Jennifer A McNab
Associate Professor (Research) of Radiology (Radiological Sciences Laboratory)
Current Research and Scholarly InterestsMy research is focused on developing magnetic resonance imaging (MRI) methods that probe brain tissue microstructure. This requires new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation. Applications of these methods include neuronavigation, neurosurgical planning and the development of improved biomarkers for brain development, degeneration, disease and injury.
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M Windy McNerney, PhD
Clinical Associate Professor (Affiliated), Psych/General Psychiatry and Psychology (Adult)
Staff, Psychiatry and Behavioral SciencesBioDr. M. Windy McNerney is the Director of Biological Sciences for the MIRECC at the Department of Veterans Affairs in Palo Alto, and a Clinical Associate Professor (Affiliated) at Psychiatry and Behavioral Sciences at Stanford School of Medicine. Dr. McNerney holds a particular passion for not only understanding the neurophysiology and biochemistry of mental health diseases, but also advocating for these invisible diseases. Her research focuses on neurodegeneration, depression, TBI, PTSD, and addiction. She is collaborating with researchers to integrate brain imaging and biochemical markers in hopes to better understand these diseases. She also is taking a lead role at the VA in investigating the biochemistry of magnetic brain stimulation and is the leader of the NeuroNado Laboratory. At Stanford University, she is the professor of two popular courses examining the biological and societal issues surrounding substance use disorder, with a major focus on opioids such as fentanyl. She has individually mentored over 25 students from underrepresented groups in STEM activities and leads monthly seminars aimed at facilitating career development. In her free time, she is a community advocate for the treatment of mental health and educates groups about the dangers of fentanyl.
She earned her BS from UC Davis and her PhD from the University of Notre Dame. While at ND, she interned at NASA Ames on Human Factors Engineering. She then went on to a postdoctoral position at Lawrence Livermore National Laboratory (DOE), and then completed a fellowship at the WRIISC program at the VA and Stanford University.
Selected Publications:
McNerney MW, Gurkoff G, Berryhill M (2023). The rehabilitation potential of neurostimulation for mild traumatic brain injury in animal and human studies. Brain Sciences, 13, 1402.
McNerney MW, Kraybill EP Narayanan S, Mojabi F, Venkataramanan V, Heath A (2023). Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line. Experimental Gerontology, 183, 11323.
Shuken, S, McNerney MW (2023). Cost and benefits for popular p-value correction methods I three models of quantitative omic experiments. Analytical Chemistry, 95, 2732.
McNerney MW, Heath A, Narayanan S, Yesavage J (2022). Repetitive transcranial magnetic stimulation improves brain-derived neurotrophic factor and cholinergic signaling in the 3xTgAD mouse model of Alzheimer’s disease. Journal of Alzheimer’s Disease, 86, 499..
Heath AM, Brewer M, Yesavage J, McNerney MW. (2021). Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation. Brain Stimulation, 15, 78.
Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Palovics R, Shin A, Wang EY, Luo J, Gate D, Schultz-Schaeffer WJ, Chu P, Siegenthalar J, McNerney MW, Keller A, Wyss-Coray T (2022). A human brain vascular atlas reveals diverse mediators or Alzheimer’s disease. Nature, 603, 885.
McNerney MW, Hobday T, Cole B, Ganong R, Winas N, Matthews D, Hood J, Lane S (2019). Objective classification of mTBI using machine learning on a combination of frontal electroencephalography measurements and self-reported symptoms. Sports Medicine Open, 4, 14.
McNerney MW, Sheng T, Nechvatal JM, Lee A, Lyons D, Adamson M (2018). Integration of neural and epigenetic contributions to posttraumatic stress symptoms: The role of hippocampal volume and glucocorticoid receptor gene methylation. PLOSONE, e0192222.
Bennion BJ, Be NA, McNerney MW, Lao V, Carlson E, Valdez CA (2017). Predicting a drug’s membrane permeability: A computational model validated with in vitro permeability assay data. Journal of Physical Chemistry, B, 121, 5228.
See more publications at: https://www.ncbi.nlm.nih.gov/pubmed/?term=McNerney%20MW%5BAuthor%5D&cauthor=true&cauthor_uid=17107728 -
Kimford Meador, MD
Professor of Neurology and Neurological Sciences (Adult Neurology)
BioDr. Meador is a Professor of Neurology and Neurosciences at Stanford University, and Clinical Director, Stanford Comprehensive Epilepsy Center. Dr. Meador graduated from the Georgia Institute of Technology in Applied Biology (with high honor) and received his MD from the Medical College of Georgia. After an internship at the University of Virginia and service as an officer in the Public Health Corps, he completed a residency in Neurology at the Medical College of Georgia and a fellowship in Behavioral Neurology at the University of Florida. Dr. Meador joined the faculty at the Medical College of Georgia (1984-2002) where he became the Charbonnier Professor of Neurology. He was the Chair of Neurology at Georgetown University (2002-2004), the Melvin Greer Professor of Neurology and Neuroscience at the University of Florida (2004-2008) where he served as Director of Epilepsy Program and Director of the Clinical Alzheimer Research Program, and Professor of Neurology and Pediatrics at Emory University (2008-2013) where he served as Director of Epilepsy and of Clinical Neurocience Research. He joined the faculty of Stanford University in 2013. Dr. Meador has authored over 400 peer-reviewed publications. His research interests include: cognitive mechanisms (e.g., memory and attention); cerebral lateralization; pharmacology and physiology of cognition; mechanisms of perception, consciousness and memory; EEG; epilepsy; epilepsy and pregnancy; preoperative evaluation for epilepsy surgery; intracarotid amobarbital procedure (i.e., Wada test); functional imaging; therapeutic drug trials; neurodevelopmental effects of antiepileptic drugs; psychoimmunology; behavioral disorders (e.g., aphasia, neglect, dementia); and neuropsychiatric disorders. Dr. Meador has served as the PI for a long running NIH multicenter study of pregnancy outcomes in women with epilepsy and their children. Dr. Meador has served on the editorial boards for Clinical Neurophysiology, Epilepsy and Behavior, Epilepsy Currents, Journal of Clinical Neurophysiology, Neurology, Cognitive and Behavioral Neurology, and Epilepsy.com. His honors include Resident Teaching Award Medical College of Georgia; Outstanding Young Faculty Award in Clinical Sciences Medical College of Georgia; Distinguished Faculty Award for Clinical Research Medical College of Georgia Lawrence C. McHenry History Award American Academy of Neurology; Dreifuss Abstract Award American Epilepsy Society; Fellow of the American Neurological Association; Diplomat of American Neurologic Association; past Chair of the Section of Behavioral Neurology of American Academy of Neurology; past President of Society for Cognitive and Behavioral Neurology; past President of the Society for Behavioral & Cognitive Neurology; past President of the Southern EEG & Epilepsy Society; ranking in the top 10 experts in epilepsy worldwide by Expertscape; Distinguished Alumnus Award for Professional Achievement, Medical College of Georgia, Georgia Regents University 2015; American Epilepsy Society Clinical Research Award; and named award by the American Epilepsy Society: “Kimford J. Meador Research in Women with Epilepsy Award,” and ranked in the top 500 neuroscientist in the world and top 300 in USA by Research.com in 2022.
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Peter Meaney
Clinical Professor, Pediatrics - Critical Care
Current Research and Scholarly InterestsDr. Meaney focuses on improving how clinically serious interventions are adopted, implemented, and scaled in real-world care environments. His work spans clinical workflow, behavior change, and performance systems, with emphasis on why clinically valid approaches fail to translate into sustained use. He develops and deploys implementation models that align product, workflow, and stakeholder incentives to enable adoption across complex health systems.
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Valerie Meausoone
Affiliate, Center for Population Health Sciences
BioValerie Meausoone is currently a Research Data Architect and Consultant at the Stanford Research Computing Center. Mrs. Meausoone has been one of the early users and testers of a computing environment for the distribution and use of high-risk and population-health related datasets at Stanford. She has also participated in efforts to expand the current Observational Medical Outcomes Partnership (OMOP) Common Data Model to administrative non-health related datasets, allowing researchers to share code on datasets. Mrs. Meausoone has recently completed various analyses aimed at leveraging existing data to better study the relationship between social constructs, such as gender norms and women's economic empowerment, and health.
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Rishi Mediratta
Clinical Professor, Pediatrics
Current Research and Scholarly InterestsI have developed a new promising neonatal mortality prediction score at the University of Gondar Neonatal Intensive Care Unit (NICU) in Gondar, Ethiopia. The score predicts approximately 84% of neonatal deaths in the NICU using clinical variables. I have a dataset over 800 NICU admissions in Gondar. I am recruiting scholars who are interested in conducting clinical and epidemiological research to validate, refine, and implement the mortality score to reduce neonatal mortality in Ethiopia.
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Natalia Medvedeva
Clinical Assistant Professor, Medicine - Infectious Diseases
BioDr Natalia Medvedeva specializes in the treatment of infectious diseases. She has a special interest in antimicrobial stewardship and medical education.
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Eric Meffre
Professor of Medicine (Immunology and Rheumatology)
BioDr. Meffre obtained his PhD in Immunology from the Université d’Aix-Marseille in France before he moved to the USA as a postdoc fellow in the laboratory of Dr. Michel Nussenzweig at The Rockefeller University in New York City. He became an assistant professor at Cornell University in 2003 before being recruited at Yale University as associate professor in 2009. He was tenured at Yale in 2014 before he joined the Department of Medicine/Division of Immunology and Rheumatology at Stanford University as a tenured full professor in 2022.
Dr. Meffre’s work focuses on the etiology of autoimmune syndromes and the roles played by B cells in these diseases. His group characterized the abnormal selection of developing autoreactive B cells in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), multiple sclerosis (MS) and Sjögren’s syndrome, resulting in large numbers of autoreactive naïve B cells accumulating in the patient’s blood. Hence, these autoreactive B cells may present self-antigens to T cells and initiate autoimmune diseases. These early B cell tolerance defects are likely primary to these autoimmune diseases and may result from genetic factors such as the 1858T PTPN22 allele that segregates with RA, SLE and T1D and correlate with an impaired removal of developing autoreactive B cells.
His research goals also consist in characterizing the molecules and pathways involved in the establishment of B cell tolerance and the removal of developing autoreactive B cells generated by random V(D)J recombination through the investigation of rare patients with primary immunodeficiency (PID) enrolled through an international network. Alteration of B cell receptor (BCR) or Toll-like receptor (TLR) signaling in PID patients results in a defective central B cell tolerance and a failure to counterselect developing autoreactive B cells in the bone marrow. In contrast, functional and suppressive regulatory T cells play a key role in preventing the accumulation of autoreactive clones in the mature naïve B cell compartment. The recent development of humanized mouse models recapitulating early B cell tolerance checkpoints and their defects in autoimmune settings allow further in-depth investigation of tolerance mechanisms and the development of novel approaches to restore defective central and peripheral B cell tolerance checkpoints and thwart autoimmunity. -
Jessica Lee Mega
Affiliate, Medicine - Med/Cardiovascular Medicine
BioJessica L. Mega, MD, MPH is a leader at the intersection of technology, life science, and health. She is a Cardiologist at Stanford and serves on the Advisory Board for Stanford's Center for Digital Health. She is a Co-Founder of Alphabet's Verily and former Chief Medical Officer of Google Life Sciences. She is on the Board of Directors at Boston Scientific, as well as the Board of Advisors for Research!America and the Duke-Margolis Center for Health Policy. She is a Senior Advisor at SandboxAQ and the Chair of the Investment Committee of the American Heart Association’s GRFW Venture Fund.
As a faculty member at Harvard Medical School, a Senior Investigator with the TIMI Study Group, and a Cardiologist at Brigham and Women’s Hospital, Dr. Mega led large, international, randomized trials evaluating novel therapies and new medical technologies. She directed the TIMI Study Group’s Genomics Program, demonstrating and testing the role of CYP2C19 genetic variants on antiplatelet medications, a key pharmacogenetic finding. She has published manuscripts in the New England Journal of Medicine, Lancet, and JAMA. She served as an Advisor for the California Governor’s Precision Medicine Initiative and the Board of Directors at Danaher Corporation.
Dr. Mega is a graduate of Stanford University, Yale University School of Medicine, and Harvard School of Public Health. She completed Internal Medicine Residency at Brigham and Women’s Hospital and Cardiovascular Fellowship at Massachusetts General Hospital. She is board certified in Internal Medicine and Cardiology. She has won the Laennec Society, Samuel A. Levine, and Douglas P. Zipes Awards, and she is a Fellow of the American Heart Association and the American College of Cardiology. -
Uchechukwu Megwalu, MD, MPH
Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsOutcomes Research
Health Disparities
Comparative Effectiveness Research
Health Literacy
Head and Neck Cancer Epidemiology
SEER database analysis -
Thulaj Dattatraya Meharwade
Postdoctoral Scholar, Cardiovascular Institute
BioDr. Thulaj Meharwade is a postdoctoral fellow at the Stanford Cardiovascular Institute with research interests in Inflammaging, disease modeling, cellular heterogeneity and drug discovery. Dr. Meharwade received his PhD in Biochemistry from the University of Montreal, after conducting thesis work on signalling and transcriptional mechanisms regulating cell fate heterogeneity and totipotent stem cells.
