School of Medicine
Showing 1-10 of 36 Results
-
Justin P. Annes M.D., Ph.D.
Associate Professor of Medicine (Endocrinology)
On Partial Leave from 05/01/2024 To 02/28/2025Current Research and Scholarly InterestsThe ANNES LABORATORY of Molecular Endocrinology: Leveraging Chemical Biology to Treat Endocrine Disorders
DIABETES
The prevalence of diabetes is increasing at a staggering rate. By the year 2050 an astounding 25% of Americans will be diabetic. The goal of my research is to uncover therapeutic strategies to stymie the ensuing diabetes epidemic. To achieve this goal we have developed a variety of innovate experimental approaches to uncover novel approaches to curing diabetes.
(1) Beta-Cell Regeneration: Diabetes results from either an absolute or relative deficiency in insulin production. Our therapeutic strategy is to stimulate the regeneration of insulin-producing beta-cells to enhance an individual’s insulin secretion capacity. We have developed a unique high-throughput chemical screening platform which we use to identify small molecules that promote beta-cell growth. This work has led to the identification of key molecular pathways (therapeutic targets) and candidate drugs that promote the growth and regeneration of islet beta-cells. Our goal is to utilize these discoveries to treat and prevent diabetes.
(2) The Metabolic Syndrome: A major cause of the diabetes epidemic is the rise in obesity which leads to a cluster of diabetes- and cardiovascular disease-related metabolic abnormalities that shorten life expectancy. These physiologic aberrations are collectively termed the Metabolic Syndrome (MS). My laboratory has developed an original in vivo screening platform t to identify novel hormones that influence the behaviors (excess caloric consumption, deficient exercise and disrupted sleep-wake cycles) and the metabolic abnormalities caused by obesity. We aim to manipulate these hormone levels to prevent the development and detrimental consequences of the MS.
HEREDIATY PARAGAGLIOMA SYNDROME
The Hereditary Paraganglioma Syndrome (hPGL) is a rare genetic cancer syndrome that is most commonly caused by a defect in mitochondrial metabolism. Our goal is to understand how altered cellular metabolism leads to the development of cancer. Although hPGL is uncommon, it serves as an excellent model for the abnormal metabolic behavior displayed by nearly all cancers. Our goal is to develop novel therapeutic strategies that target the abnormal behavior of cancer cells. In the laboratory we have developed hPGL mouse models and use high throughput chemical screening to identify the therapeutic susceptibilities that result from the abnormal metabolic behavior of cancer cells.
As a physician scientist trained in clinical genetics I have developed expertise in hereditary endocrine disorders and devoted my efforts to treating families affected by the hPGL syndrome. By leveraging our laboratory expertise in the hPGL syndrome, our care for individuals who have inherited the hPGL syndrome is at the forefront of medicine. Our goal is to translate our laboratory discoveries to the treatment of affected families. -
Danit Ariel
Clinical Associate Professor, Medicine - Endocrinology, Gerontology, & Metabolism
BioDanit Ariel, MD MS, is board certified in Endocrinology. Dr. Ariel graduated from UC Davis School of Medicine. She then completed a residency in Internal Medicine at Stanford and a fellowship and post-doctorate in Endocrinology and Metabolism at Stanford before joining the faculty at Stanford.
Dr. Ariel practices general endocrinology, with a special interest in menopause, LGBTQ+ health, transgender medicine, reproductive endocrinology and thyroid disorders amongst others.
She believes in practicing compassionate care: in listening to her patients’ concerns, respecting their values, communicating well, and providing an evidence-based approach to help guide individualized treatment plans. She is deeply committed to utilizing her expertise in the field of endocrinology to optimize her patients’ health and well-being.
Dr. Ariel is passionate about medical education and teaching, and serves on the teaching faculty in the Stanford University School of Medicine. She completed an honors certificate in medical education from Stanford. She is the Founding Director of the Student Guidance Program for medical students. Finally, within the division of Endocrinology, she is the Director of Faculty Wellness.
Appointments with with Dr. Ariel are available in the Hoover Pavilion on 211 Quarry Road as part of the Stanford Health Care Endocrinology Clinic and the Stanford Health Care LGBTQ+ Health Program. -
Marina Basina
Clinical Professor, Medicine - Endocrinology, Gerontology, & Metabolism
Current Research and Scholarly InterestsDiabetes type I and type II, insulin pump therapy, glucose sensor technology, insulin resistance, PCOS, thyroid disorders
-
Julia J. Chang, MD
Clinical Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism
Clinical Assistant Professor (By courtesy), NeurosurgeryBioDr. Chang is a board-certified endocrinologist. She is a Clinical Assistant Professor in Stanford Medicine’s Division of Endocrinology and, by courtesy, the Department of Neurosurgery. She specializes in pituitary disorders, including prolactinomas, Cushing disease, acromegaly, non-functional pituitary masses and cysts, and hypopituitarism, as well as transgender health and gender-affirming hormone care.
For each patient, she develops a comprehensive, compassionate care plan personalized to individual needs. Her goal is always the best possible health and quality of life for every patient in her care.
Dr. Chang actively leads several pituitary and transgender care research, quality improvement, and education initiatives. She teaches Stanford trainees and serves as the associate program director for the Stanford Endocrinology Fellowship. She has published widely and presented her research at international conferences and is a member of the Endocrine Society, Pituitary Society, and the World Professional Association of Transgender Health. She is a native English speaker, and she also understands Korean.
In-person and telehealth appointments with Dr. Chang are available at Stanford Endocrinology Clinic at Hoover Pavilion, Pituitary Center at Stanford Neurosciences Health Center, and the Stanford Brain Tumor Center at Stanford Cancer Center. She is also a part of the LGBTQ+ Health Program. -
Julie Chen
Clinical Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism
BioJulie Chen, MD, is a board-certified endocrinologist and clinical assistant professor in the division of endocrinology at Stanford University. Dr. Chen diagnoses and treats a wide range of conditions with a focus on endocrine tumors that affect the thyroid, parathyroid, adrenal, and pituitary glands. She also works closely with cancer specialists to treat the endocrine side effects associated with immunotherapy. Dr. Chen recognizes that patients are more than their disease. She views her relationship with each patient as a partnership and develops a personalized care plan for each one. Dr. Chen is committed to helping patients achieve the best possible outcomes through comprehensive treatment.
Dr. Chen is also passionate about medical education and mentoring. She currently serves as the Program Director for the Endocrinology Fellowship Program at Stanford University. She has given numerous lectures to medical students, residents, and fellows. -
Katrin Chua
Professor of Medicine (Endocrinology, Gerontology and Metabolism)
Current Research and Scholarly InterestsOur lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.
-
Lawrence Crapo
Professor of Medicine (Endocrinology, Gerontology and Metabolism) at the Santa Clara Valley Medical Center, Emeritus
Current Research and Scholarly InterestsInvestigation of the epidemiology of diabetic ketoacidosis (DKA) at a public hospital. All cases of DKA at SCVMC occurring over the past 5 years have been identified. Of the 480 cases of DKA, about 1/3 are in Type II diabetics, and 2/3 in Type I diabetics. We are exploring the causes of DKA in the two groups.
-
Dimpi Desai
Clinical Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism
BioDr. Dimpi Desai, MD is a Clinical Assistant Professor at Stanford University. She did her residency in Internal Medicine from Jacobi Medical Center/Albert Einstein College of Medicine in New York and completed her fellowship in Endocrinology at the University of Pennsylvania.
Her main clinical focus includes diabetes and obesity and preventing their long-term complications. She strongly believes in patient education and involving them in the medical decision-making process. In addition to being a clinician, she is committed to and involved in the medical education of trainees at all levels including medical students, residents and fellows. She is double board certified in internal medicine and endocrinology. -
Kaniksha Desai
Clinical Associate Professor, Medicine - Endocrinology, Gerontology, & Metabolism
BioDr. Kaniksha Desai is a board-certified endocrinologist and clinical associate professor at Stanford University. She completed her endocrinology fellowship at the Mayo Clinic, with an emphasis on the management of patients with thyroid cancer. Dr. Desai’s clinical practice focuses on the management of patients with thyroid nodules and thyroid cancer. She also maintains board certification in neck ultrasonography.
-
Chrysoula Dosiou
Clinical Professor, Medicine - Endocrinology, Gerontology, & Metabolism
Current Research and Scholarly InterestsI am highly interested in the interactions between the endocrine and immune systems in women. Current clinical research interests lie in the field of autoimmune thyroid disease, especially thyroid autoimmunity in pregnancy.
